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  • 1
    Electronic Resource
    Electronic Resource
    Physico-chemical aspects of metabolically induced changes at the basic centre of two anti-emetics; relationship with in vivo membrane penetration (1980)
    Springer
    Pharmacy world & science 2 (1980), S. 253-261 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Partition coefficients in three solvent systems (1-octanol/ 0.1N NaOH,n-heptane/0.1N NaOH and toluene/0.1N NaOH), ionisation constants and thin-layer and reverse phase high pressure liquid chromatography retention data were determined for metoclopramide, its mono- and di-N-dealkylated metabolites, and for clebopride and its N-debenzylated metabolic product. Values for the additive-constitutive parameters π, ΔR m andx were calculated for the alkyl substituents at the basic centre of the two drugs, and the results are discussed. The relationship between these physico-chemical parameters and thein vivo membrane penetrating capacity (this capacity was determined using buccal absorption measurements) is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272989
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The acetylcholinesterase inhibitory activity of metoclopramide and some of its biotransformation products (1980)
    Springer
    Pharmacy world & science 2 (1980), S. 1121-1127 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Ki values were determined for thein vitro acetylcholinesterase inhibitory activity of the anti-emetic metoclopramide, some of its metabolic products and the newly synthesised N-(ethyl)-4-chlorobenzamide (1). Metoclopramide was a moderate inhibitor, 113 times more potent than 1 and 50 times less potent than physostigmine. Metabolic products of N-de-ethylation, N-di-de-ethylation, deamination followed by reduction and amide hydrolysis were increasingly less active as inhibitors. The implications of the present findings are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02273269
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Uromyces viciae-fabae onVicia faba: Scanning electron microscopy of frozen-hydrated material (1982)
    Springer
    Protoplasma 111 (1982), S. 28-37 
    Details
    ISSN: 1615-6102
    Keywords: Frozen-hydrated ; Low temperature SEM ; Uredium ultrastructure ; Uromyces viciae-fabae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The ultrastructure of uredia, intercellular and intracellular hyphae ofUromyces viciae-fabae onVicia faba has been studied by scanning electron microscopy of frozen-hydrated material. Frozen-hydrated leaves will readily fracture and can be viewed on the cold stage of the microscope at liquid nitrogen temperatures for several hours without visible surface changes occurring. Both fungal and host-plant cells show a high degree of morphological preservation with little or no loss of cell contents and with minimal signs of shrinkage. Intracellular hyphae may be filamentous and branched or short and lobed. They are constricted at the point of entry into the host cell. Intercellular matrix material is well preserved around developing pedicels and urediospores and may act as a lubricant. The technique described is very quick compared with conventional preparatory procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287644
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The ultrastructure of septal pores and associated structures in the ascogenous hyphae and asci ofSordaria humana (1981)
    Springer
    Protoplasma 107 (1981), S. 127-147 
    Details
    ISSN: 1615-6102
    Keywords: Asci ; Ascomycetes ; Ascogenous hyphae ; Croziers ; Intercellular communication ; Septal pores ; Sordaria humana
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Septal pores and associated structures have been studied in ascogenous hyphae, croziers and asci ofSordaria humana by means of electron microscopy of serial and random sections. Pores exhibit variable structures from relatively simple pore caps to complex swollen rims with associated membrane cisternae. The simple types are found at the base of the ascogenous hyphae while the complex forms occur at the apex, in the croziers and in very young, presporulation asci. Post-sporulation asci contain a relatively simple type of pore structure. Cells which subtend the ascogenous hyphae exhibit both open and capped pores in their cross walls. Pore structures may be asymmetric in which case they show greater complexity on the side of the cross wall nearest to the apex or crozier. Membranous components of the complex pores are continuous with the endomembrane systems of the two adjacent cells and thus with the outer membranes of the nuclear envelopes. Membrane continuities may connect prefusion nuclei or fusion nuclei in penultimate cells, with nuclei of the stalk and terminal cells of croziers. Some speculation is presented as to the implication and possible roles of these structures in relation to cell differentiation within the ascogenous hyphae and croziers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01275613
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructure and behaviour of the spindle pole body of the aphid-pathogenic fungusErynia neoaphidis (1984)
    Springer
    Protoplasma 120 (1984), S. 61-71 
    Details
    ISSN: 1615-6102
    Keywords: Fungus ; Spindle pole body ; Entomophthoraceae ; Erynia neoaphidis ; Ultrastructure ; Replication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A detailed account of the ultrastructure and behaviour of the spindle pole body (SPB) of the entomophthoraceous fungusErynia neoaphidis is presented for the first time. The SPB consists of extranuclear (ENC) and intranuclear (INC) components. The ENC is a “saucepan-shaped” structure which lies in a pocket of the nuclear envelope. It is composed of a forked, fibrillar “handle” and a shallow, cylindrical “pan”. The “pan” has a wall of two layers, both of which are thickened with a regular periodicity so that they appear to be “beaded”. It is postulated that the “pan“ is formed from rough endoplasmic reticulum and that it synthesizes the amorphous, electron-dense material coating the ENC. The INC is a “saucer-shaped”, electron-dense plaque in which the ends of the spindle microtubules terminate. During metaphase, a “clear zone” separates the INC from the nuclear envelope and persists until telophase. The roles of the amorphous, electron-dense material and the “clear zone” as well as the method of SPB replication are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287618
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructure of mitosis in the aphid-pathogenic fungusErynia neoaphidis (1984)
    Springer
    Protoplasma 120 (1984), S. 72-83 
    Details
    ISSN: 1615-6102
    Keywords: Fungus ; Mitosis ; Entomophthoraceae ; Erynia neoaphidis ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An account of mitosis in the aphid-pathogenic, entomophthoraceous fungusErynia neoaphidis is presented. The mitotic apparatus is characterized by a closed, intranuclear, polarized spindle. Chromosomes are permanently attached by kinetochore microtubules (kcMTs) to the poles during mitosis. The spindle develops as the spindle pole bodies migrate and separate. At metaphase the eccentric spindle contains only kcMTs and is located in a relatively chromatinfree zone. Paired sister kinetochores are arranged in a broad metaphase plate. During anaphase kcMTs shorten, astral and nonchromosomal microtubules develop and elongate and the interpolar distance increases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01287619
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    Paper (German National Licenses)
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