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  • 1980-1984  (3)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    The lungs in fatal measles infection in childhood: pathological, radiological and immunological correlations (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 4 (1980), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Multinucleated inclusion-bearing giant cells diagnostic of measles infection were identified in the pulmonary alveoli of seven children post mortem. Two children with leukaemia and a third with thymic dysplasia had prolonged illnesses without typical measles exanthemata. All showed a striking proliferation of the respiratory epithelia, with formation of peribronchiolar fibro-epithelial nodules and cystic transformation of tracheo-bronchial glands. The nodular lesions contained many giant cells and were seen radiologically as multiple slowly-enlarging pulmonary opacities, a pattern which appears to be highly characteristic of measles infection in the presence of cellular immune deficiency. Two other children showed similar proliferative lesions, but had shorter illnesses with exanthemata and few tissue giant cells; these differences are attributed to the late appearance of a cellular immune response in less severe immune deficiencies. Two children who had no evidence of immune deficiencies died of acute viral alveolitis, one in the preexanthematous phase. Acute alveolitis was characterized radiologically by the rapid development of diffuse pulmonary opacification and by variable cytological features which correlated with other evidence for the presence or absence of a cellular immune response against the virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1980.tb02935.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Failure of protein loading tests to identify heterozygosity for ornithine carbamoyltransferase deficiency (1984)
    Springer
    Journal of inherited metabolic disease 7 (1984), S. 157-159 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Protein loading tests for the diagnosis of heterozygous ornithine carbamoyltransferase deficiency were performed on two occasions on an asymptomatic woman whose daughter and two infant sons died of the disease. Neither loading test produced the expected increases in urinary orotic acid excretion and studies of other pyrimidine and purine metabolites in urine and plasma did not suggest that these would provide better discrimination from non-carriers. The results probably reflect an extensive inactivation of the mutant X chromosome in liver cells and reinforce the need for caution in interpreting negative test results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805599
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pyrimidine and purine metabolites in ornithine carbamoyl transferase deficiency (1981)
    Springer
    Journal of inherited metabolic disease 4 (1981), S. 27-31 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Detailed biochemical studies have been carried out in a female heterozygote for ornithine carbamoyltransferase (OCT) deficiency. Increased levels of the pyrimidines, orotic acid, uridine and uracil, were observed in plasma as well as urine by utilizing an adaptation of high performance liquid chromatography (HPLC). Urinary clearances of these compounds were high, that of orotic acid indicating net secretion. Urinary uric acid clearance was also elevated, a finding attributed to the uricosuric effect of the orotic acid excreted concomitantly. The results in this child and her family are typical of OCT deficiency. They confirm considerable genetic heterogeneity in the biochemical as well as clinical expression in this defect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02263578
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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