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  • 1
    Electronic Resource
    Electronic Resource
    Haemodynamic and hormonal changes during acute and chronic diuretic treatment in essential hypertension (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 107-112 
    Details
    ISSN: 1432-1041
    Keywords: chlorthalidone ; essential hypertension ; haemodynamics ; plasma renin activity ; plasma aldosterone ; urinary noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The short- and long-term effects of diuretic treatment with chlorthalidone 50 mg/day on haemodynamic and hormonal parameters in patients with essential hypertension (WHO grade I) were investigated. After three days of treatment, all patients showed a rise in plasma renin activity (PRA), plasma aldosterone (PA), urinary norepinephrine excretion (UNE) and heart rate (HR), and a decrease in body weight (BW) and extracellular volume (ECV) and blood volume (BV); the change in blood pressure (BP) was variable. The changes in BP were correlated with those in BV. After three months of therapy, the signs of volume depletion tended to fade, but the lower ECV persisted. In contrast to the 4-day study, after three months the change in BP correlated inversely with changes in ECV and renin dependency (saralasin response), and positively with PRA and changes in UNE. It is concluded that the BP response to diuretic treatment is determined by the adaptation with time of the haemodynamic reactions to the volume-depleted state. Whether this adaptation will take place cannot be predicted from the control values of the parameters studied, or from acute changes observed during the first days of treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568396
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanical effects of micro-organisms on intertidal bedform migration (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 28 (1981), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Attention is called to the ability of bottom-dwelling micro-organisms such as algae to stabilize sandy sediment surfaces in non-carbonate environments and to influence sand transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1981.tb01670.x
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of topically applied fluorides on the surface free energy of human dentin (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 19 (1984), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The surface free energy γs of human dentin treated with sodium fluoride, acidulated phosphate fluoride, and aminfluoride solutions has been determined by means of contact angle measurements. Application of an aminfluoride solution slightly increased the total surface free energy from 75 to 80 erg. cm−2. The γs values of dentin after a neutral sodium fluoride application decreased to 62 erg. cm−2. APF solutions hardly influenced the surface free energy γs. This study showed that fluoride applications change the surface free energy of human dentin.Extrapolation of the results of this study and the in vitro results on cell spreading indicated that aminfluoride applications might be favorable for the reattachment of periodontal tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1984.tb01310.x
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  • 4
    Electronic Resource
    Electronic Resource
    Determination of glomerular filtration rate by 111In-DTPA (1981)
    Springer
    European journal of nuclear medicine 6 (1981), S. 551-553 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the use of 111indium-diethylene-triamine pentaacetic acid (111In-DTPA) for determination of the glomerular filtration rate (GFR), the results of 60 standard 111In-DTPA clearances were compared with 24-h urine endogenic creatinine clearances obtained on 3 successive days (r=0.97, P〈0.0001) and with endogenic creatinine clearances obtained during 111In-DTPA determinations (r=0.93, P〈0.0001). It is concluded that 111In-DTPA is a useful marker for GFR
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252668
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  • 5
    Electronic Resource
    Electronic Resource
    Meiosis of T70H translocation trisomic male mice (1982)
    Springer
    Chromosoma 87 (1982), S. 315-325 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Meiosis of T70H/+, Ts(113)70H translocation trisomic male mice has been studied using C-banded preparations and 3H-thymidine autoradiography of the first meiotic division. Epididymal sperm counts and sperm morphology scores were also collected. As reported earlier, at the first meiotic division the translocation involved chromosomes 1, 13, 131 and 113 (twice) formed mainly three multivalent configurations: Chain III+II, CIV+I and CV. — The autoradiographic study indicated an abnormal, precocious spiralization pattern for the chromatin in CIV+I primary spermatocytes. These cells, occurring together with the CIII+II and CV configurations in recognizable groups, usually descending from single spermatogonial stem cells, are delayed through meiotic prophase. Both delay and disturbed chromosome spiralization in these cells are attributed to the uniform association of the univalent (I) chromosome 113 with the sex chromosomes during pachytene. Primary spermatocytes of the CIV+I configuration and those carrying a CV take longer to develop from metaphase I into secondary spermatocytes than does the CIII+II type. — In T70H tertiary trisomics with a similar chromosome imbalance, the majority of primary spermatocytes degenerates during the diakinesis-metaphase I stages of meiosis. Fertility is low in contrast to the translocation trisomics. Comparison between the two types leads to the conclusion, that trisomy per se reduces the size of the testes and that the univalent containing CIV+I primary spermatocytes, contrary to the almost uniformly 113 univalent carrying spermatocytes of the T70H tertiary trisomics are rescued by the neighbouring CIII+II and CV carrying cells to form normal secondary spermatocytes and morphologically normal sperm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327633
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  • 6
    Electronic Resource
    Electronic Resource
    Meiosis of T70H translocation trisomic male mice (1982)
    Springer
    Chromosoma 87 (1982), S. 303-313 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Meiosis of T70H/+,Ts(113)70H translocation trisomic male mice has been studied using C-banded preparations of multivalents at the first meiotic division, marker chromosomes at the second meiotic division, and sucrose-spread pachytene spermatocytes for the observation of synaptonemal complexes. During zygotene and pachytene the three marker chromosomes, 131 (long) and 113 (2 x, small) associate with the chromosomes 1 and 13 to form either a Chain of three plus bivalent (CIII+II), a Chain of four plus univalent (CIV+I) or a Chain of five (CV). During pachytene, the 113 univalent of the CIV+I configuration shows association with the sex chromosomes in the sex vesicle while for CV, the unpaired segment of chromosome 1 can do so. — The frequencies of the multivalent configurations during late diplotenemetaphase I were CIII+II, 47.6%, CIV+I, 34.5% and CV, 14.4%. However, among late diplotene-early diakinesis cells, the frequency of CIV+I was 12.9% while in (late) spermatocytes with contracted bivalents it was 45.7%. — The notion that proximity of the interstitital chiasma of chromosome 13 to the centromere affects the chances of non-disjunction for these centromeres within the multivalent (i.e., adjacent 2 segregation) has been strengthened by the observed adjacent 2 frequency of 13.0% in the translocation trisomics compared to the 26.3% found in T70H/+ translocation heterozygotes with more proximal chiasmata. Thus, for reciprocal translocations between acrocentric chromosomes, a proximally located chiasma in an interstitial segment enhances the chance of adjacent 2 segregation. — Other parameters of irregular chromosome behaviour at anaphase I, such as equational separation of chromosome 113 into chromatids and non-disjunction of normal bivalents, were increased in the translocation trisomics when compared with T70H/+ translocation heterozygotes, especially among adjacent 2 segregating cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327632
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  • 7
    Electronic Resource
    Electronic Resource
    On the survival of populations in a heterogeneous and variable environment (1981)
    Springer
    Oecologia 50 (1981), S. 39-53 
    Details
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The survival time of small and isolated populations will often be relatively low, by which the survival of species living in such a way will depend on powers of dispersal sufficiently high to result in a rate of population foundings that about compensates the rate of population extinctions. The survival time of composite populations uninterruptedly inhabiting large and heterogeneous areas, highly depends on the extent to which the numbers fluctuate unequally in the different subpopulations. The importance of this spreading of the risk of extinction over differently fluctuating subpopulations is demonstrated by comparing over 19 years the fluctuation patterns of the composite populations of two carabid species, Pterostichus versicolor with unequally fluctuating subpopulations, and Calathus melanocephalus with subpopulations fluctuating in parallel, both uninterruptedly occupying the same large heath area. The conclusions from the field data are checked by simulating the fluctuation patterns of these populations, and thus directly estimating survival times. It thus appeared that the former species can be expected to survive more than ten times better than the latter (other things staying the same). These simulations could also be used to study the possible influence of various density restricting processes in populations already fluctuating according to some pattern. As could be expected, the survival time of a population, which shows a tendency towards an upward trend in numbers, will be favoured by some kind of density restriction, but the degree to which these restrictions are density-dependent appeared to be immaterial. Density reductions that are about adequate on the average need even not occur at high densities only, if only the chance of occurrence at very low densities is low. The density-level at which a population is generally fluctuating appeared to be less important for survival than the fluctuation pattern itself, except for very low density levels, of course. The different ways in which deterministic and stochastic processes may interact and thus determine the fluctuations of population numbers are discussed. It is concluded that some stochastic processes will operate everywhere and will thus necessarily result in density fluctuations; such an omnipresence is much less imperative, however, for density-dependent processes, by which population models should primarily be stochastic models. However, if density-dependent processes are added to model populations, that are already fluctuating stochastically the effects are taken up into the general, stochastic fluctuation pattern, without altering it fundamentally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00378792
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  • 8
    Electronic Resource
    Electronic Resource
    Spontaneous meiotic non-disjunction in mammals. A study evaluating the various experimental approaches (1981)
    Springer
    Genetica 56 (1981), S. 99-122 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This report reviews and evaluates the various methods and techniques used for measuring the incidence of spontaneous meiotic non-disjunction in mammals generally and particularly in mouse and man. It also gives the principal results obtained with these methods and techniques and consequently, in a sense, is also a review of the incidence of meiotic non-disjunction in these species. The incidence of non-disjunction is only given for normal meiosis. Studies involving chromosomal aberrations, e.g. of translocation carriers, have not been included.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00055412
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  • 9
    Electronic Resource
    Electronic Resource
    Chiasma frequency and position in male and female mice of chromosomes involved in homozygous and heterozygous translocations and tertiary trisomy (1983)
    Springer
    Genetica 61 (1983), S. 205-213 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Chiasma frequency and position were analyzed at a predominantly late diplotene-diakinesis stage of the first meiotic division in oocytes and spermatocytes from T(1;13)70H homozygotes and heterozygotes, T(2;8)26H heterozygotes and from Ts(I13)70H tertiary trisomics of the mouse, Mus musculus. For T70H/T70H, the 131 long marker bivalent was studied and for the other karyotypes, analysis was confined to the multivalent configurations adopted by the rearranged chromosomes and their homologues. For the 131 bivalent, the chiasma frequency tended to be increased in the female. For the T26H and the T70H multivalents, the chiasma frequencies were higher in the female, largely due to the much higher values in the short interstitial segments. This observed enhancement has been attributed to pairing differences rather than to differences in chiasma forming capability. Both in the telomeric region of the 131 bivalent and in the short translocated segments of the reciprocal translocation and tertiary trisomic multivalents, females showed fewer chiasmata than males. The determinations of chiasma position in the 131 bivalent indicated chiasma interference with respect to position, leading to clustering of chiasmata somewhat beyond the centromere and towards the telomere of this chromosome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00123724
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  • 10
    Electronic Resource
    Electronic Resource
    A sequential analysis of the development of the synaptonemal complex in spermatocytes of the mouse by electron microscopy using hydroxyurea and agar filtration (1983)
    Springer
    Genetica 61 (1983), S. 119-129 
    Details
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A method is presented for sequential analysis of the development and behaviour of the Synaptonemal Complex (SC) in primary spermatocytes of male mice, using agar filtration for electron microscope grid preparation. The mice were treated with hydroxyurea (HU) to produce a gap in the spermatogenic line. The front of surviving cells behind the gap was examined day by day. The first visible parts of unpaired axial elements, with some barely recognizable paired regions were found 9 days after the last HU injection i.e. directly after the last S-phase before meiosis. During mid zygotene and late zygotene the axes of the autosomes had a fuzzy ill-defined appearance with irregular regions of apparent thickening. The axes of the XY pair could be recognized only at late zygotene. During pachytene the SCs of the autosomal pairs did not show a significant change except for a slight increase in size of the attachment points of the axial elements. On the first day of pachytene the axes of the XY pair appeared thin and long. On the second day the axes of the XY pair showed maximal pairing of about 50% of the axis of the Y chromosome. From the third to the fifth day a decrease of the paired region of the sex chromosomes was found together with an increase in thickness of the axes, which reached its maximum on the fourth day. Diplotene could be easily recognized: the autosomal axes showed a sharp, well-defined outline with thick attachment points with deltoid structure, and desynapsis was very clear. The axes of the XY pair showed variation during diplotene but on the third day of diplotene a characteristic bulging could be seen. The axes of the autosomes disappeared at this time and in most cases only the attachment points remained visible. The duration of the prophase classes of meiosis I was found to be: zygotene approximately 2 days; pachytene a little more than 5 days and diplotene approximately 3 days. Leptotene could not be traced by the method used. If it exists at all, it must be a stage of very short duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00123222
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