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  • 1980-1984  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 833-834 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The specific benzodiazepine antagonist, Ro 15-1788, elicited withdrawal symptoms in squirrel monkeys, cats, rats and mice made tolerant and physically dependent by subchronic administration of high doses of diazepam, lorazepam or triazolam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972300
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Selective antagonists of benzodiazepines (1981)
    [s.l.] : Nature Publishing Group
    Nature 290 (1981), S. 514-516 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Working on a series of imidazodiazepines, we found compounds which were potent inhibitors of the specific high-affinity binding of 3H-diazepam to brain synaptosomal fractions, but which failed to produce any of the behavioural and neurological effects typical of benzodiazepines. Detailed analysis ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/290514a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents (1982)
    Springer
    Psychopharmacology 78 (1982), S. 104-111 
    Details
    ISSN: 1432-2072
    Keywords: Aniracetam ; Piracetam ; Learning ; Memory ; Hypercapnia ; Scopolamine ; ECS ; Cycloheximide ; Chloramphenicol ; Rats ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of aniracetam (Ro 13-5057, 1-anisoyl-2-pyrrolidinone) was studied on various forms of experimentally impaired cognitive functions (learning and memory) in rodents and produced the following effects: (1) almost complete prevention of the incapacity to learn a discrete escape response in rats exposed to sublethal hypercapnia immediately before the acquisition session; (2) partial (rats) or complete (mice) prevention of the scopolamine-induced short-term amnesia for a passive avoidance task; (3) complete protection against amnesia for a passive avoidance task in rats submitted to electroconvulsive shock immediately after avoidance acquisition; (4) prevention of the long-term retention- or retrieval-deficit for a passive avoidance task induced in rats and mice by chloramphenicol or cycloheximide administered immediately after acquisition; (5) reversal, when administered as late as 1 h before the retention test, of the deficit in retention or retrieval of a passive avoidance task induced by cycloheximide injected 2 days previously; (6) prevention of the deficit in the retrieval of an active avoidance task induced in mice by subconvulsant electroshock or hypercapnia applied immediately before retrieval testing (24 h after acquisition). These improvements or normalizations of impaired cognitive functions were seen at oral aniracetam doses of 10–100 mg/kg. Generally, the dose-response curves were bell-shaped. The mechanisms underlying the activity of aniracetam and its ‘therapeutic window’ are unknown. Piracetam, another pyrrolidinone derivative was used for comparison. It was active only in six of nine tests and had about one-tenth the potency of aniracetam. The results indicate that aniracetam improves cognitive functions which are impaired by different procedure and in different phases of the learning and memory process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432244
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    Paper (German National Licenses)
    Fulltext
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