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  • 1
    Electronic Resource
    Electronic Resource
    Correlation of individual symptoms and other clinical variables with cerebrospinal fluid amine metabolites and tryptophan in depression (1981)
    Springer
    European archives of psychiatry and clinical neuroscience 229 (1981), S. 345-353 
    Details
    ISSN: 1433-8491
    Keywords: CSF monoamines ; Depression ; Symptoms ; Tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA), homovanillic acid (HVA), and tryptophan in both CSF and plasma were measured in a carefully selected group of 33 depressed women. Strict and explicit inclusion and exclusion criteria were used, and CSF was taken under controlled circumstances. Seventeen operationally defined and uniformly rated psychiatric symptoms as well as global depression severity and 12 clinical background variables were correlated with the four biochemical parameters, using multivariate regression analysis based on Spearman's rank correlation coefficient according to the nature of the data. Global depression severity did not correlate with any of the biochemical variables; there were, however, significant correlations between CSF 5HIAA and anxiety, insomnia, and suicide on the one hand, and between CSF HVA and motor symptoms and paranoidity on the other hand. Background variables showed only a few-and much weaker-correlations. It was concluded that central monoamine metabolism does affect some particular psychiatric symptoms but is not parallel with the complex clinical construct of the depressive disease. Further studies using isolated psychopathological symptoms instead of nosological categories are suggested in clinical neurochemistry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01833162
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  • 2
    Electronic Resource
    Electronic Resource
    Ion concentrations in serum and cerebrospinal fluid of patients with neuromuscular diseases (1982)
    Springer
    European archives of psychiatry and clinical neuroscience 231 (1982), S. 251-258 
    Details
    ISSN: 1433-8491
    Keywords: Ions ; Cerebrospinal fluid ; Neuromuscular diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 62 Patienten mit neuromuskulären Erkrankungen und bei 17 Kontrollpatienten wurde die Konzentration von Na+, K+, Ca2+, Mg2+, Cl− und anorganischem Phosphor (Pi) im Serum und im lumbalen Liquor vergleichend gemessen, und die Werte wurden statistisch bearbeitet. Obwohl keine für die verschiedenen Erkrankungstypen charakteristischen Veränderungen beobachtet werden konnten, ist die signifikante Erhöhung der Pi-Konzentration im Serum bei Duchenne-Dystrophie doch erwähnenswert. Die eventuellen Veränderungen der Ionenkonzentration im Serum und im Liquor können zur Diagnosestellung bei verschiedenen neuromuskulären Erkrankungen beitragen.
    Notes: Summary The Na+, K+, Ca2+, Mg2+, Cl−, and Pi concentrations in serum and lumbar CSF of 17 controls and 62 patients with neuromuscular diseases were determined and the values statistically evaluated. Although alterations in ion concentrations specifical to different groups were not observed in either of these biological fluids, the significant increase in serum Pi concentration in Duchenne muscular dystrophy seems to be remarkable. It is suggested that the possible alterations in the ion content of the serum and CSF may contribute additional data to the diagnosis of various neuromuscular diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343295
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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