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  • 1
    Electronic Resource
    Electronic Resource
    Chloroform anaesthesia in Liverpool (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 38 (1983), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The introduction of chloroform into anaesthesia is described, together with an account of the parts played by Simpson and Waldie and their connexions with Liverpool. An account of the first chloroform anaesthetics administered in Liverpool is also given; David Waldie, who suggested the use of chloroform, was one of the administrators at the first demonstration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1983.tb14072.x
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction between barley yellow dwarf virus and powdery mildew in four barley genotypes (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 30 (1981), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The effect of infection by barley yellow dwarf virus (BYDV) on host reaction to powdery mildew (Erysiphe graminis DC. f. sp. hordei Marchal) in four barley genotypes with different types of resistance to barley mildew isolate AB3, was studied in pot-grown plants at 7,12 and 26 days after mildew inoculation. Cv. Engledow India (hypersensitive resistance) showed necrotic spotting only at the third scoring date, but the area showing symptoms was significantly less in BYDV-infected than in control plants. On Vada (intermediately resistant), the reaction type value (a measure of host/pathogen compatibility), the percentage leaf area covered with mildew and the coefficient of infection (C.I., a mathematical combination of the other two characters mentioned) were initially less and subsequently greater on BYDV-infected than on virus-free plants. However, the initial trend was significant only for reaction type and C. I., and the subsequent trend only for percentage mildew cover and C.I. Reaction type values, percentage mildew cover and C.l. on cv. Emir (susceptible with some degree of adult plant resistance) and cv. Golden Promise (very susceptible) were also initially significantly less on BYDV-infected plants, but subsequently all three characters increased to amounts not significantly different from those on virus-free plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1981.tb01244.x
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  • 3
    Electronic Resource
    Electronic Resource
    Seismic reflections from subducting lithosphere? (1983)
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 668-670 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Data from two short reflection lines obtained using explosives and an airgun source, together with offshore and onshore refraction profiles and a gravity interpretation, provide evidence of coherent reflections between the subducting oceanic Juan de Fuca and overriding continental America ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/303668a0
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  • 4
    Electronic Resource
    Electronic Resource
    Study of porcine and human isophane (NPH) insulins in normal subjects (1984)
    Springer
    Diabetologia 26 (1984), S. 261-265 
    Details
    ISSN: 1432-0428
    Keywords: Porcine NPH insulin ; semi-synthetic and biosynthetic human NPH insulin ; pharmacokinetics ; pharmacodynamics ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The plasma glucose, C-peptide and insulin responses to subcutaneously administered highly purified porcine, ‘semi-synthetic’ and ‘biosynthetic’ human isophane (NPH) insulin and diluting medium as control in normal male subjects were evaluated. Porcine and semi-synthetic human NPH insulins were administered at two dose levels of 0.15 and 0.30 U/kg body weight and biosynthetic human NPH at 0.15 U/kg body weight only. At the low dose level the three insulin preparations resulted in a similar maximal hypoglycaemic effect within 3–5 h after administration. However, over the remainder of the 11 h post-injection period, the plasma glucose level was lower after semi-synthetic human insulin. In contrast, at the 0.30 U/kg dose level, there was no difference in the early or late hypoglycaemic response between porcine and semi-synthetic human NPH insulins of equivalent pharmaceutical formulation. The clinical relevance of these findings needs further evaluation. The data suggest that for the ‘intermediate-acting’ NPH insulin preparations, both the species of insulin, nature and quantity of the retarding protein and their subsequent interaction may determine their time-action characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00283647
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  • 5
    Electronic Resource
    Electronic Resource
    Lanthanide-ion transport across phospholipid vesicular membranes: a comparison of alamethicin 30 and A23187 using1H-NMR spectroscopy (1982)
    Springer
    Bioscience reports 2 (1982), S. 921-928 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The kinetics of Pr3+ transport by the ionophores alamethicin 30 and A23187 across unilamellar phospho-lipid vesicular membranes has been compared by following the time-dependent changes in the1H-NMR spectrum of the vesicles. The measured rates of transport allow stoichiometries of the transporting species to be deduced which are consistent with channel- and carrier-mediated mechanisms respectively. The method provides a useful complement to planar bilayer conductivity studies of these systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01114899
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  • 6
    Electronic Resource
    Electronic Resource
    Phosphatidic acid regulates the activity of the channel-forming ionophores alamethicin, melittin, and nystatin: A1H-NMR study using phospholipid membranes (1984)
    Springer
    Bioscience reports 4 (1984), S. 403-413 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The regulation of ion channels by phosphatidic acid (a proposed active metabolite in the phosphatidylinositol effect) was investigated using1H-NMR spectroscopy and small unilamellar phospholipid vesicles. Transport across egg-yolk phosphatidylcholine (egg PC) and dipalmitoyl phosphatidylcholine (DPPC) vesicular membranes in the presence of the channel-forming ionophores alamethicin, melittin, and nystatin was monitored using the lanthanide probe ion Pr3+. In the absence of the ionophores, phosphatidic acid (PA) alone was found to have no ionophore properties, but in the presence of the ionophores the incorporation of 3 mol % phosphatidic acid in the bilayer markedly increased the rate of transport using melittin and nystatin, but decreased the rate using alamethicin, independent of the type of phosphatidylcholine used. The presence of PA in the bilayer also stimulated the production of lyric type channels, the extent of which were both ionophore- and lipid-dependent. These results are discussed in terms of possible molecular interactions between the PA, the individual ionophores, and type of lipid used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01122505
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  • 7
    Electronic Resource
    Electronic Resource
    Transgressive segregation for enhanced level of adult plant resistance to mildew in the oat cross Mostyn x Maldwyn (1983)
    Springer
    Euphytica 32 (1983), S. 499-503 
    Details
    ISSN: 1573-5060
    Keywords: Avena sativa ; oat ; Erysiphe graminis f.sp. avenae ; powdery mildew ; adult plant resistance ; transgressive segregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary In the cross Mostyn x (Mostyn x Maldwyn), 87 F6 lines with relatively high levels of adult resistance resulting from selection in previous generations, were field tested for severity to mildew infection in 1980. Of the 74 lines which proved to be homozygous regarding the Mostyn gene (AA or aa), 16 (including three lacking the Mostyn major gene-aa) proved to have significantly lower percentage leaf area infected than the most resistant parent at growth stages ranging from late ‘boot’ to ‘early milk’ ripeness of the grain. Some lines showed 10–15% less mildew than the adult plant resistant parent Maldwyn. There was some evidence to suggest that the presence of the now ‘overcome’ and ineffective major gene in Mostyn may have enhanced the level of partial resistance in this cross even in the presence of the corresponding virulence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00021461
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  • 8
    Electronic Resource
    Electronic Resource
    Observations of LRO in Pd-Ce solid solution alloys (1982)
    Springer
    Journal of materials science 1 (1982), S. 463-466 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00721930
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  • 9
    Electronic Resource
    Electronic Resource
    Hot isostatic pressing of beta-alumina (1980)
    Springer
    Journal of materials science 15 (1980), S. 2311-2316 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The effect of hot isostatic pressing on the properties of sintered beta-alumina has been investigated. The mechanical strength is increased as compared with as-sintered material. The ionic resistivity is decreased by hot isostatic pressing but this has been shown to be related to the heat treatment rather than the application of pressure. The changes in mechanical and electrical properties are related to changes in ceramic microstructure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00552321
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  • 10
    Electronic Resource
    Electronic Resource
    Maintenance of some ColE1-type plasmids in chemostat culture (1980)
    Springer
    Molecular genetics and genomics 180 (1980), S. 579-584 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary When cells carrying the plasmids RP1, pDS4101 (a ColK derivative) or pDS1109 (a ColE1 derivative) were maintained in chemostat culture in the absence of antibiotic selection, plasmid-free segregants were not detected after 120 generations of nutrient-limited growth. By contrast, plasmid-free segregants of pMB9- and pBR322-containing cells arose after approximately 30 generations, irrespective of the host genetic background. However, even though pDS1109 was maintained its copy-number fell five-fold during 80 generations of limited growth. It is suggested that loss of pBR322 occurs following a similar copy-number decrease which results in defective segregation of the plasmid to daughter host cells. This defective segregation was not complemented in trans by either RP1 or pDS4101.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00268063
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