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  • 1
    Electronic Resource
    Electronic Resource
    Kinetics of the reaction of chromium(II) with (3-cyano-2,4-pentanedionato-N)pentaamminecobalt(III): intramolecular electron transfer between cobalt(III) and chromium(II) (1983)
    s.l. : American Chemical Society
    Inorganic chemistry 22 (1983), S. 3309-3314 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00164a026
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The disposition of inhaled lysine theophylline in volunteers (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 635-637 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; inhalation ; saliva-serum distribution ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543500
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Griffin, Audrey: Sikyon : Oxford University Press, 1982 (1983)
    Cambridge : Cambridge University Press
    The @classical review 33 (1983), S. 258-260 
    Details
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0009840X00111837
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hyatt, Stephen L.: The Greek Vase : Latham, N.Y., Hudson-Mohawk Association of Colleges and Universities, 1981 (1983)
    Cambridge : Cambridge University Press
    The @classical review 33 (1983), S. 92-94 
    Details
    ISSN: 0009-840X
    Source: Cambridge Journals Digital Archives
    Topics: Classical Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0009840X00101519
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Subcutaneous infusion of cytosine arabinoside (1983)
    Springer
    Cancer chemotherapy and pharmacology 10 (1983), S. 112-114 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The administration of cytosine arabinoside (araC) by continuous IV infusion requires the patient to be in hospital and have prolonged IV cannulation. In this study the pharmacokinetics of araC during continuous IV infusion were compared with those of continuous SC infusion in six patients with acute myelogenous leukaemia. Each patient acted as his own control. The mean plasma levels of araC reached a plateau within 2 h and the plasma concentrations and the area under the curve were similar for both methods of administration. The mean area under the curve (AUC) was 1147±230 ng/ml for the IV infusion and 1017±238 ng/ml for the SC infusion. The plasma araC concentrations showed wide interpatient variation, and there was also considerable variability in the plasma concentrations of araC within the individual patients after a plateau had apparently been reached. Subcutaneous infusion was well tolerated by the patients without any local discomfort or excoriation and SC infusion of araC is thus a feasible alternative to IV infusion. It allows the patients the benefits of being at home, while avoiding unnecessary thrombophlebitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446221
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  • 6
    Electronic Resource
    Electronic Resource
    Delayed-release bleomycin (1984)
    Springer
    Cancer chemotherapy and pharmacology 13 (1984), S. 19-21 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental and clinical evidence indicates that bleomycin by continuous infusion is superior to intermittent administration. Continuous infusion is less convenient, however. It has been suggested that a suspension of bleomycin in sesame oil, given by IM injection, simulates a continous infusion. The pharmacokinetics of this formulation have been compared with those of bleomycin in saline following IM injection, in six patients. The pharmacokinetic profiles of the two formulations were similar. The only difference between the profiles was the long terminal half-life at very low concentrations between 12 and 48 h after injection of the oil suspension. This difference is of unknown, but doubtful, clinical significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401440
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  • 7
    Electronic Resource
    Electronic Resource
    The efficiency of protective gloves used in the handling of cytotoxic drugs (1984)
    Springer
    Cancer chemotherapy and pharmacology 12 (1984), S. 151-153 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A range of clinical and industrial gloves have been evaluated to determine their ability to exclude penetration by cytotoxic drugs. Radiolabelled cyclophosphamide, methotrexate, daunomycin, cytosine arabinoside, and vincristine sulphate were studied in an equilibrium dialysis system in which the glove material was used as the dialysis membrane. The thicker gloves were the most effective, but very little drug crossed any of the gloves tested under laboratory conditions. Further studies to evaluate gloves in conditions of clinical use are now needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256536
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  • 8
    Electronic Resource
    Electronic Resource
    The bioavailability of oral intermediate-dose methotrexate (1984)
    Springer
    Cancer chemotherapy and pharmacology 13 (1984), S. 91-94 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The oral bioavailability of methotrexate is variable and may be dose-dependent. The absorption of ‘interval’ oral methotrexate, which is given between cycles of chemotherapy, is unknown. The bioavailability of oral methotrexate has been studied in eight patients, acting as their own controls, to assess the effect of subdivision of the dose, the formulation, and the timing of the methotrexate within the chemotherapy cycle. The mean bioavailability for all the oral methods of administration was 28.2%±3.7% compared with the same dose given IV. Absorption was uninfluenced by subdivision of the dose, liquid or tablet formulation, or administration on day 1 or day 10 of the chemotherapy cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257121
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  • 9
    Electronic Resource
    Electronic Resource
    Development of orthopyroxene-Fe/Mg ferrite symplectites by continuous olivine oxidation (1984)
    Springer
    Contributions to mineralogy and petrology 88 (1984), S. 196-202 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The development of orthopyroxene-Fe/Mg ferrite symplectites associated with olivine is discussed with respect to the chemical reactions by which they form. Previously proposed reactions are presented graphically and the differences between them are reviewed. With the exception of exsolution, these are all discontinuous reactions in the sense that olivine is replaced by the two-phase symplectite assemblage. Olivine-hosted symplectites developed in the margins of lherzolite xenoliths from Kauai, Hawaii, demonstrate a reaction mechanism which has not been previously documented from natural samples. Original Fo90 olivine in these samples oxidized to a new assemblage consisting of orthopyroxene (En92–95)-Fe/Mg ferrite (Mf35–50) symplectites developed within more magnesian olivine (Fo92–96) hosts. Thus, by this mechanism, olivine of a different composition persists as part of a final three-phase assemblage. As oxidation advanced, the compositions of all three product phases became continuously more magnesian and the stoichiometric coefficients of the orthopyroxene and Fe/Mg ferrite continuously increased, whereas those of the product olivine decreased in the mass-balance equations. These characteristics demonstrate that the reaction was controlled by oxygen diffusion into the xenoliths from the highly oxidized alkali picrite melt in which they were entrained. Thermodynamic calculations suggest that a gradient in oxygen fugacity of 100.9 bars existed across the xenolith rims and resulted in compositional gradients of 4 mol% fayalite and ferrosilite and 15 mol% magnetite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371423
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  • 10
    Electronic Resource
    Electronic Resource
    Multiple asperity model for earthquake prediction (1981)
    [s.l.] : Nature Publishing Group
    Nature 289 (1981), S. 231-234 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Large earthquakes often occur as multiple ruptures reflecting strong variations of stress level along faults. Dense instrument networks with which the volcano Kilauea is monitored provided detailed data on changes of seismic velocity, strain accumulation and earthquake occurrence rate before the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/289231a0
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