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Lymphocyte transformation test in detection of drug hypersensitivity (1981)

DOBOZY, A. ; HUNYADI, J. ; KENDERESSY, ANNA SZ. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental dermatology 6 (1981), S. 0

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ISSN: 1365-2230

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Four thousand, three hundred and ninety-two lymphocyte transformation tests with seventy-nine different drugs were performed in 1723 patients because of the clinical suspicion of drug hypersensitivity. The optimal stimulating concentration and the lowest cytotoxic concentration were determined for every drug, and transformation tests were carried out only with those drugs whose optimal stimulating concentration was lower than its lowest cytotoxic concentration.The transformation tests gave positive results in 557 of the 1723 patients (32%); hypersensitivity to one drug could be confirmed in 410 cases (24%), and to two or more drugs in 147 cases (9%). It is considered that the test is a valuable in vitro method in the diagnosis of drug allergy, and that its application can lead to a substantial decrease in the number of patients who must be subjected to the possible risk of in vivo tests for the determination of the sensitizing drug.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2230.1981.tb02319.x

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Regulation of lymphokine production in peripheral blood mononuclear cell cultures (1982)

Dobozy, A. ; Csató, M. ; Kenderessy, Anna Sz. ; [et al.]

Springer

Cellular and molecular life sciences 38 (1982), S. 505-506

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ISSN: 1420-9071

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary An increase in the production of macrophage migration inhibitory factor, chemotactic factor for neutrophils, and skin reactive factor, was observed in lymphocyte cultures if the cells were allowed to age in culture for 24 h. The increased lymphokine production was reduced by adding concanavalin A-stimulated and mitomycin C-treated suppressor cells. It is suggested that the lymphokine production could be regulated by suppressive mononuclear cells.