Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental dermatology
6 (1981), S. 0
ISSN:
1365-2230
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Four thousand, three hundred and ninety-two lymphocyte transformation tests with seventy-nine different drugs were performed in 1723 patients because of the clinical suspicion of drug hypersensitivity. The optimal stimulating concentration and the lowest cytotoxic concentration were determined for every drug, and transformation tests were carried out only with those drugs whose optimal stimulating concentration was lower than its lowest cytotoxic concentration.The transformation tests gave positive results in 557 of the 1723 patients (32%); hypersensitivity to one drug could be confirmed in 410 cases (24%), and to two or more drugs in 147 cases (9%). It is considered that the test is a valuable in vitro method in the diagnosis of drug allergy, and that its application can lead to a substantial decrease in the number of patients who must be subjected to the possible risk of in vivo tests for the determination of the sensitizing drug.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-2230.1981.tb02319.x
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