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  • 1
    Electronic Resource
    Electronic Resource
    Exocrine pancreatic tumours and their histological classification. A study based on 167 autopsy and 97 surgical cases (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 7 (1983), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Based on histopathological examination of 264 exocrine pancreatic tumours (167 autopsy and 97 surgical) from the files of the Institute of Pathology, University of Hamburg, over a 15-yr period (1966–1980), a histogenetic classification is proposed. In addition to the more common neoplasms this also includes rarer and more recently defined entities. Of the 264 tumours, 250 were of duct origin, 10 acinar and four of uncertain histogenesis. Ductal adenocarcinoma, subdivided into a well-differentiated and a poorly-differentiated type, was most frequent (81.1%), followed by its variants: pleomorphic giant cell carcinoma 5·3%, adenosquamous carcinoma 3·8%, and mucinous carcinoma 1.1%. All these had a poor prognosis. Serous cystadenoma (1.1%), mucinous cystic tumour (1.5%) and intraductal papilloma (0.8%), which were rare tumours and mostly apparent in surgical material, proved to be benign or of only latent malignancy. The group of tumours of acinar cell origin consisted of the solid and cystic tumour (2.7%) with favourable prognosis and the acinar cell carcinoma (1.1%). No pancreatoblastoma was observed. The pleomorphic carcinomas of the small cell type (1.5%) were classed as tumours of uncertain histogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1983.tb02277.x
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  • 2
    Electronic Resource
    Electronic Resource
    Pancreatic duct ligation and pancreatic polypeptide (PP) secretion (1982)
    Springer
    Journal of molecular medicine 60 (1982), S. 211-212 
    Details
    ISSN: 1432-1440
    Keywords: PP secretion ; Pancreatic duct ligation ; PP-Sekretion ; Pankreasgangligatur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die basale und durch eine Testmahlzeit stimulierte Sekretion des Pankreatischen Polypeptids (PP) wurde bei 5 Schweinen 4–6 Wochen nach einer Pankreasgangligatur untersucht, bei 2 Schweinen zusätzlich nach 14 bzw. 16 Wochen. Bei allen Versuchstieren zeigte die Autopsie die erwartete extreme Atrophie des exokrinen Pankreasgewebes. Die basale und postprandiale PP-Sekretion wurde dagegen durch die Pankreasgangligatur nicht beeinflußt.
    Notes: Summary The basal and meal-stimulated secretion of pancreatic polypeptide (PP) were measured before and 4–6 weeks after pancreatic duct ligation in five piglets, in two piglets also after 14 and 16 weeks. In all animals histology revealed the expected extreme atrophy of the exocrine pancreatic tissue. Basal and postprandial PP secretion, however, were not altered after duct ligation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715589
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  • 3
    Electronic Resource
    Electronic Resource
    Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis (1980)
    Springer
    Virchows Archiv 387 (1980), S. 221-233 
    Details
    ISSN: 1432-2307
    Keywords: Pancreatic duct proliferations ; Normal pancreas ; Pancreatic carcinoma ; Chronic pancreatitis ; Pancreatic carcinogenesis in man and animals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 21 patients who had undergone total pancreatectomy for pancreatic head carcinoma, the uninvolved pancreas was examined with regard to the type, incidence and regional distribution of duct epithelial proliferation. The results were compared with those in 37 operative specimens from patients with chronic pancreatitis, in 46 normal pancreases from autopsies and with findings in experimental pancreatic carcinogenesis. While the incidence of squamous metaplasia and non-papillary epithelial hypertrophy varied little in the different groups, papillary epithelial hyperplasia was found three times more often in cases of carcinoma, with associated mild duct obstruction. Atypical epithelial proliferation was only detected in the vicinity of carcinomas. Unequivocal transition from papillary hyperplasia to atypical proliferation was not observed. In hamsters treated with dihydroxy-di-n-propylnitrosamine (DHPN) for induction of pancreatic duct carcinomas, the early duct lesions closely resembled atypical epithelial proliferation of human pancreas. It is concluded that (1) papillary epithelial hyperplasia is probably only indicative of early duct obstruction and/or a general neoplastic stimulus, (2) intraductal epithelial proliferation with atypia is a true precursor of duct carcinoma, and (3) chronic pancreatitis lacks atypical duct lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430702
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  • 4
    Electronic Resource
    Electronic Resource
    Pancreatic PP cell distribution and hyperplasia (1980)
    Springer
    Virchows Archiv 387 (1980), S. 319-331 
    Details
    ISSN: 1432-2307
    Keywords: Endocrine pancreas ; PP cells ; Immunocytochemistry ; Distribution ; Normal pancreas ; Chronic pancreatitis ; Pancreatic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The endocrine pancreatic tissue from 13 patients with severe chronic pancreatitis, 5 patients with pancreatic duct carcinoma and 4 non-diseased pancreases was analysed by immunocytochemistry and morphometry. The controls revealed two distinct islet types with different regional distribution. The lower dorsal part of the pancreatic head contained islets with irregular outlines and a high number of PP cells (PP-cells 60.4±4.1%; B-cells 29.4±4.6%; A-cells 7.4±1.5%; D-cells 2.8±0.6%). The other parts of the pancreas contained compact islets with only a few PP cells (PP-cells 1.0±0.4%; B-cells 69.3±3.0%; A-cells 24.1±2.1%; D-cells 5.8±0.5%). In chronic pancreatitis the sclerotic tissue of the body and the tail region contained compact islets with altered cell inter-relationships when compared with controls. While the number of B-cells was diminished (48.5%), A and PP cells appeared to be increased in number (42.7 and 4.1%, respectively). Furthermore, ductulo-insular proliferations were conspicuous (nesidioblastosis) with budding-off of small endocrine cell clusters made up predominantly of A and PP cells. In 3 patients with pancreatic carcinoma increased numbers of PP cells and of A cells were found along the advancing edge of the carcinoma. The data emphasize the necessity of taking into consideration regional PP cell distribution in each case in which an increase of PP cells is observed. True hyperplasia is found in chronic pancreatitis and, focally, in some cases with pancreatic carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454835
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  • 5
    Electronic Resource
    Electronic Resource
    Pancreatic glucagonoma with and without syndrome (1980)
    Springer
    Virchows Archiv 388 (1980), S. 51-67 
    Details
    ISSN: 1432-2307
    Keywords: Glucagonomas ; Morphological features ; Immunocytochemistry ; Review of literature ; Classification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five patients single or multiple glucagonomas were characterized by immunocytochemistry. Two large single glucagonomas were associated with the glucagonoma syndrome, which completely dissappeared after removal of the tumours. The morphologic findings in these patients are compared with 48 others collected from literature. In the other three patients, the glucagonomas were not associated with a clinical syndrome and were detected by chance (one accompanying an insulinoma; the other in pancreases of patients suffering from multiple endocrine neoplasia I; MEN I). These tumours appeared by their histological, immunocytochemical and ultrastructural features better organized than the glucagonomas with syndrome. Glucagonomas not producing a syndrome can be classified into (a) solitary, often malignant endocrine pancreatic tumours, (b) glucagonomas associated with insulinomas and other tumours, (c) multiple glucagonomas in MEN I and (d) single microglucagonomas in elderly patients. It is emphasized that only immunohistology allows clear identification of these tumours as glucagonomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430676
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  • 6
    Electronic Resource
    Electronic Resource
    Solid and cystic acinar cell tumour of the pancreas (1981)
    Springer
    Virchows Archiv 392 (1981), S. 171-183 
    Details
    ISSN: 1432-2307
    Keywords: Pancreas tumours ; Young women ; Acinar cell origin ; Classification ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinico-pathological features of five cases with a distinctive pancreatic tumour are presented. The tumours, which occurred only in young women and an adolescent girl, were of large size (2.5–10 cm), had an uncharacteristic symptomatology and showed fibrous encapsulation with no evidence of metastases. The histological features include (1) solid areas with a monomorphic cell pattern and intracellular PAS positive globules, and (2) large foci of degeneration with cystic necroses, haemorrhages and cholesterol granulomas. Some tumour cells were positive for α1-antitrypsin. The ultrastructural demonstration of zymogen-like granules suggests an acinar origin for the tumours. We therefore propose the term solid and cystic acinar cell tumour. This tumour resembles the so called pancreatoblastomas in small children in some respects. It must be clearly distinguished, on the other hand, from acinar cell carcinoma with its acinic structures and poor prognosis. This lesion is not included in the WHO classification of pancreatic neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430819
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  • 7
    Electronic Resource
    Electronic Resource
    In vivo diagnosis of massive hepatic infarction by computed tomography (1982)
    Springer
    Digestive diseases and sciences 27 (1982), S. 73-79 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient is presented with a postpartum hepatic artery thrombosis in association with presumed fibromuscular hyperplasia. Massive hepatic infarction developed characterized clinically by fever, coma, ascites, ileus, jaundice, and renal failure; and biochemically by markedly elevated SGOT and SGPT, alkaline phosphatase, total bilirubin levels, and decreased thromboplastin time. The diagnosis was made in vivo by computed tomography (CT). Angiography revealed thrombotic occlusion of the hepatic artery in association with presumed fibromuscular hyperplasia. Laparoscopy and biopsy confirmed the diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01308124
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  • 8
    Electronic Resource
    Electronic Resource
    Die tumorhemmende Wirkung von Cholestyramin in der Hepatocarcinogenese (1981)
    Springer
    Langenbeck's archives of surgery 354 (1981), S. 19-29 
    Details
    ISSN: 1435-2451
    Keywords: Bile acids ; Diethylnitrosamine ; Hepatocarcinogenesis ; Cholestyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß von Cholestyramin in der Hepatocarcinogenese wurde an Wistar—Ratten untersucht. Nach 14wöchentlicher intragastraler Applikation von 50 mg Diäthylnitrosamin/kg entwickelten bei simultaner Verabreichung von 1,3 % Cholestyraminzusatz im Futter die Hälfte der Versuchstiere Lebertumoren. Dagegen kam es unter ähnlichen experimentellen Bedingungen, aber ohne Cholestyramin im Futter bei fast allen Tieren der Kontrollgruppe zu Tumorentstehung. Die Sequestration von Gallensäuren und die verminderte Bildung der toxischen Lithocholsäure konnte als Erklärung herangezogen werden, warum im Experiment die Induktion von Lebercarcinom durch Diäthylnitrosamin reduziert wird.
    Notes: Summary The influence of cholestyramine on hepatocarcinogenesis was investigated in the Wistar rat. After 14 weekly gastric instillation of 50 mg diethylnitrosamine/kg and simultaneous administration of diet supplement with 1.3 % cholestyramine, half of the animals developed hepatic tumors. In contrast, nearly all the animals in the control group under similar experimental conditions, but without the cholestyramine supplement in their diet, developed hepatic tumors. The sequestration of bile acids and the reduction of the noxious lithocholic acid could be considered as an explanation for the modification of hepatic tumors induced by diethylnitrosamine in the Wistar rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834013
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