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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 170 (1981), S. 117-133 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The development in rabbits of antibodies against common thermolabileEscherichia coli surface antigens — and against O and K antigens — was investigated. Three strains, E3b (O75:K95:H5), E56b (O8:K27:H-), and H61 (O45:K1:H10), and five rabbits per strain were used. Immunization was carried out by routine procedures using non-heated whole cell vaccines. Homologous and heterologous reactions were recorded. Bacterial agglutination showed no great differences between homologous antisera. Maximum agglutination titers were reached after three immunizations, i.e., 12 days after the first immunization. The development of antibodies to the many single common and specific antigens was followed by examination in crossed immunoelectrophoresis (CIE). Indication of immune tolerance of polysaccharide K27 antigen was found. The finding of pre-immune antibody and the rapid response to immunization indicate that many of the reactions recorded should be regarded as secondary responses. Several antigens in the three strains were identical or serologically related. The common cross-reacting thermolabile surface antigens showed similar electrophoretic mobility in the three strains. Some rabbits were found to be overall good producers of antibodies and some were poor. The occurrence or absence of pre-immune antibody to common antigens could not be used to select the good antibody producers. It is suggested that the immune response to the common surface antigens that could be reckoned as outer membrane proteins may influence the relationship between host and bacterium.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0630
    Keywords: 89.60 ; 35.80 ; 06.70
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Laser heterodyne spectroscopy (LHS) techniques with semiconductor laser local oscillators (LO) in the 3–30 μm range have the potential to measure radical gas species in the stratosphere. The goal of this experiment is to measure radical gases from Spacelab, including ClO, ClONO2, HO2, H2O2, N2O5, and HOCl in solar occulation with vertical resolution ≦2km and vertical range from 10 to 70 km. Sensitivity analyses have been performed on ClO and O3 to determine design criteria for the LHS instrument. Results show that O3 and ClO vertical profiles can be measured with an accuracy ≧95% and ≧80%, respectively, over the total profile. These accuracies require the LO to maintain the following characteristics: frequency stability (Δf w≦20 MHz), single-mode power (P LO≧500 μW), and minimum frequency drift (≦5 MHz). Laboratory heterodyne measurements performed with semiconductor lasers generated the same shot-noise photocurrent as CO2 lasers, for comparable single-mode power. “Excess-noise” regions were identified, but could be wavelength controlled by fine control of operating temperature and injection current. Doppler-shift effects and limited solar occultation measurement times due to Spacelab orbits should pose minimum mission constraints on the experiment.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 18 (1980), S. 135-139 
    ISSN: 1432-1041
    Keywords: hypertension ; labetalol ; propranolol ; renal haemodynamics ; glomerular filtration rate ; blood pressure ; exercise ; renal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of exercise on renal haemodynamics was examined in young patients with mild essential hypertension. Four groups of subjects were studied: 13 normotensive, healthy control subjects, and 15 untreated, 11 propranolol-treated, and 6 labetalol-treated patients. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were measured during four consecutive periods, a pre-exercise control period, two exercise periods with loads of 450 kpm/min and 600 kpm/min, respectively, and a post-exercise control period. In the untreated patients RPF and GFR were lower during exercise than in the normotensive control subjects, whereas no significant differences were found at rest. In the propranolol-treated patients the reduction in RPF and GFR during exercise was more pronounced than in the untreated hypertensives. In the labetalol-treated patients however, RPF and GFR were reduced only to the same degree as in the untreated hypertensives. The reduced renal blood flow in propranolol-treated patients may be attributed to a compensatory increase in sympathetic activity caused by an impaired cardiac response to exercise. The lack of reduction in renal blood flow during labetalol therapy could partly be related to alpha-adrenergic blockade in the renal vascular bed induced by labetalol, and partly to the smaller reduction in cardiac output during labetalol than during propranolol therapy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 48 (1983), S. 2097-2098 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a randomized trial, three alternative schemes of treatment of preterm labour with ritodrine (long infusion, short infusion, and intramuscular injection) were compared with standard treatment by bed rest and sedatives. None of the ritodrine treatments were found to be better in postponing delivery than the standard treatment. However, the Bishop scores of the patients in the standard treatment group tended to be lower than of the patients treated with ritodrine. Moreover, all cases of congenital malformation and polyhydramnios occurred in the patients treated with ritodrine. The incidence of respiratory insufficiency was significantly higher in infants of mothers treated with ritodrine. The mean birth weight was highest in the standard treatment group.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Teaching statistics 6 (1984), S. 0 
    ISSN: 1467-9639
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2072
    Keywords: Dopamine agonists ; Autoreceptors ; 3-PPP ; Neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacological profile of the enantiomers of the proposed selective dopamine (DA) autoreceptor agonist 3-PPP [3-(3-hydroxyphenyl)-N-n-propylpiperidine] has been studied. In vitro both enantiomers showed weak DA agonistic activity, and (-)-3-PPP some DA antagonistic effect on DA-stimulated adenylate cyclase activity. Both enantiomers in low doses had a similar profile in vivo: Inhibition of locomotor activity of mice and rats, induction of contralateral circling behaviour in 6-hydroxy-DA-lesioned rats and an emetic effect in dogs. At higher doses, differential effects of the enantiomers were found: (+)-3-PPP induced hyperactivity, weak stereotyped behaviour and ipsilateral circling in hemitransected rats. (-)-3-PPP had depressant effects in high doses, inhibited d-amphetamine-induced hyperactivity and d-amphetamine-, methylphenidate- and apomorphine-induced stereotyped licking/biting in rats and antagonized apomorphine-induced emesis in dogs. However, (+)-3-PPP also showed a weak antagonistic activity against d-amphetamine-induced hyperactivity and d-amphetamine-and apomorphine-induced stereotypy in rats and inhibited apomorphine-induced emesis in dogs. It is suggested that both enantiomers have significant effects on postsynaptic DA receptors in high doses: (-)-3-PPP with weak antagonistic activity in some test models and (+)-3-PPP with agonistic and antagonistic effect. Since these effects of (+)-3-PPP were of low intensity at high doses, (+)-3-PPP may be a partial DA agonist at postsynaptic receptors in high doses. Interaction experiments with neuroleptics indicated that only (-)-3-PPP significantly increased the antistereotypic effect of neuroleptics in rats. Therefore, the proposed DA autoreceptor stimulation is possibly unrelated to the neuroleptic potentiation.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Basic research in cardiology 75 (1980), S. 428-432 
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vanadat wurde als Na3VO4 anästhesierten Katzen i.v. gegeben.Ein deutlicher, kurzzeitiger und reversibler vasokonstriktorischer Effekt wurde registriert an den viszeralen Arterien (auch A. renalis), nicht aber an Femoralarterien und den Karotiden. Die Vasokonstriktion der Nierenarterien ist begleitet von einer hochgradigen Einschränkung der glomerulären Filtrationsrate und der Urinproduktion. Die gemessene Vasokonstriktion scheint die Folge einer direkten Vandatwirkung auf die Gefäßwand zu sein, deren Mechanismus nicht bekannt ist.
    Notes: Summary The present experiments demonstrate that vanadate (sodium orthovanadate) given i.v. to anesthetized cats induces a marked, transient and reversible constriction of visceral arteries, including the renal artery, whereas the femoral and carotid artery escape constriction. The constriction of the renal artery is accompanied by a pronounced reduction of glomerular filtration rate and urine production. The vasoconstriction appears to be caused by a direct effect of vanadate on the vessel wall, but the mechanism of action is not established.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International urology and nephrology 14 (1982), S. 393-397 
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a retrospective study the postoperative weight of one hundred prostatic adenomas was compared with the preoperative estimated size, based on rectal digital palpation. As a basis for the choice between transurethral and transvesical resection the adenomas were classified by digital palpation in three weight groups: less than 20 g, 20–40 g and more than 40 g. The objective was to avoid transvesical resection in small adenomas and transurethral resection in large ones, weighing more than 40 g. No adenomas weighing less than 20 g were removed transvesically. About one fourth of the adenomas removed transurethrally weighed more than 40 g. Forty-five per cent of the adenomas were placed erroneously into the 20 g group. Rectal digital palpation is a very unreliable method of assessing prostatic size, however, very small adenomas can be identified. Urethrocystoscopy can be of aid in identifying the very large ones.
    Type of Medium: Electronic Resource
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