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  • 1
    Electronic Resource
    Electronic Resource
    The Effect of Anti-Ia Antibody on Immunoglobulin-secreting Cells from Healthy Individuals and Myeloma Patients (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 15 (1982), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Immunoglobulin-secreting cells (ISC) in the peripheral blood of healthy individuals and in the bone marrow, peripheral blood, or plasmacytomas of patients with multiple myeloma were enumerated by a protein-A plaque-forming cell assay after treatment with anti-Ia antibody and complement. Rabbit anti-human B-cell antisera and monoclonal anti-Ia antibody (OKIal) were used. By this treatment, the number of ISC in the peripheral blood of healthy individuals decreased to half, and that of M-protein-secreting cells from some patients with multiple myeloma also decreased markedly. In one patient, the number of M-protein-secreting cells in the bone marrow were markedly reduced by this treatment, but this was not the case after 6 months of chemotherapy, suggesting that the chemo therapy reduced chiefly the Ia-positive myeloma cells rather than Ia-negative myeloma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1982.tb00685.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of β-cyclodextrin on disposition of hexobarbital and phenobarbital in mice (1984)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 2 (1984), S. 613-621 
    Details
    ISSN: 1573-1111
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effect of β-cyclodextrin (β-CD) on the disposition of hexobarbital (HBA) and phenobarbital (PhBA) after intravenous administration, with the simultaneous administration with β-CD, was investigated in mice. In the case of HBA, the whole blood concentration was slightly heightened, the brain and liver concentrations were significantly lowered, and the kidney concentration was significantly heightened. Moreover, β-CD also influenced the disposition and formation of 3′-hydroxy- and 3′-keto-HBA. On the other hand, in the case of PhBA, the whole blood concentration was slightly lowered, the time at maximum brain concentration (t-max) was prolonged about 30 to 60 min, the kidney concentration was significantly heightened at the initial stage, while the liver concentration did not show a clear difference by the simultaneous administration with β-CD. These results suggest that the disposition of drugs might be modified by the use of CD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662227
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  • 3
    Electronic Resource
    Electronic Resource
    Inclusion complex of cinnarizine withβ-cyclodextrin in aqueous solution and in solid state (1984)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 2 (1984), S. 511-521 
    Details
    ISSN: 1573-1111
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Inclusion complex formation of cinnarizine (CN) with β-cyclodextrin (β-CD) in aqueous solution and in solid state was confirmed by the solubility method, powder X-ray diffractometry, differential scanning calorimetry (DSC) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The apparent stability constant, K′, of the complex in water at 20°C was estimated as 6.2×103M−1. The stoichiometry of the complex was given as the ratio 1∶2 of CN to β-CD. The dissolution rate of CN/β-CD complex which could be prepared three different methods, coprecipitation method, neutralization method and spray-drying method, was much more rapid than intact CN, i.e., about 30 times or more. The degradation of CN in acidic solution was found to be of pseudo first-order reaction. The pseudo first-order rate constant with β-CD decrease with an increase in concentration of β-CD at pH 1.20. The inclusion complex prepared by spray-drying method was very stable under heating conditions and under high humid conditions. There was no difference in the bioavailability of CN between oral administration of β-CD complex and that of CN alone. The absorption of CN decreased significantly when CN administered with NaHCO3. However, there was observed no decrease in the case of CN/β-CD inclusion complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00662217
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  • 4
    Electronic Resource
    Electronic Resource
    The structure of carbonatobis(2,2'-bipyridine)ruthenium(II) tetrahydrate (1982)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 38 (1982), S. 112-115 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740882002180
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  • 5
    Electronic Resource
    Electronic Resource
    Nachweis von Esterase D (EsD) und Glyoxalase I (GLO) an menschlichen Haarwurzeln mittels Agarosegel-Dünnschichtelektrophorese (1983)
    Springer
    International journal of legal medicine 90 (1983), S. 15-18 
    Details
    ISSN: 1437-1596
    Keywords: Esterase D, in human hair roots ; Glyoxalase I, in human hair roots ; Esterase D, in Haaren ; Glyoxalase I, in Haaren
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Esterase D und Glyoxalase I sind mittels Agarosegel-Dünnschichtelektrophorese an Haarwurzeln zweifelsfrei nachweisbar. Die Darstellung gelingt auch am Einzelhaar.
    Notes: Summary The authors describe the examination of esterase D and glyoxalase I in human hair roots that showed evidence also in using a single hair root.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01886062
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  • 6
    Electronic Resource
    Electronic Resource
    Die Gc-Subtypen: Darstellung mittels isoelektrischer Fokussierung (1983)
    Springer
    International journal of legal medicine 90 (1983), S. 45-52 
    Details
    ISSN: 1437-1596
    Keywords: Gc-subtypes ; Blood groups, Gc ; Gc-Subtypen ; Blutgruppen, Gc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Gc-Subtypen wurden an Seren von 492 unausgewählten Berliner Blutspendern durch isoelektrische Fokussierung und Immunfixation bestimmt. Die Allelfrequenzen betragen: Gc1F = 0,1270, Gc1S = 0,6006, Gc2 = 0,2724. Die Untersuchungen an 78 Familien mit 190 Kindern ergab keine Abweichung vom angenommenen, autosomal kodominanten Erbgang. Die Untersuchungen von 636 Erwachsenen aus dem laufenden Paternitätsmerkmal sowie von 205 Kindern ergab annähernd gleiche Ergebnisse. Seltene Allele wurden im vorliegenden Material nicht beobachtet.
    Notes: Summary Gc-subtypes were determined by isoelectric focusing and immunfixation on samples from 492 unrelated blood donors from Berlin. The frequency of the three genes was found to be Gc1F = 0.1270, Gc1S = 0.6006, Gc2 = 0.2724. Analysis of 78 parents with 190 children did not show deviations from the expected mode of inheritance. Investigation of the adults from paternity cases and of their children on the other hand obtained similar results. No rare alleles were observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01886066
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