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  • 1980-1984  (4)
  • 1
    Digitale Medien
    Digitale Medien
    Measurement of free thyroid hormones in patients on long-term phenytoin therapy (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 633-634 
    Details
    ISSN: 1432-1041
    Schlagwort(e): phenytoin ; thyroid hormones ; thyroid function tests ; free thyroxine ; free triiodothyronine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Total thyroxine and triiodothyronine levels are often reduced in long-term phenytoin therapy, a finding at variance with the euthyroid clinical state of these subjects. We have measured free (biologically active) thyroid hormone levels in 31 patients on phenytoin therapy and have found a significant reduction in measurements of both free thyroxine and free triiodothyronine. In contrast, addition of phenytoin to normal serum in vitro resulted in an increase in free thyroxine and free triiodothyronine concentrations. The findings in vitro are consistent with displacement of thyroid hormones from thyroxine binding globulin while the reduced free hormone levels in vivo confirm that the effects of phenytoin are not confined to binding inhibition and suggest that phenytoin has induced a change in the cellular metabolism of thyroid hormones.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543499
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  • 2
    Digitale Medien
    Digitale Medien
    3,5-diiodotyrosine excretion in human urine in individuals of differing thyroidal status (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1983), S. 507-511 
    Details
    ISSN: 0306-042X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The urinary excretion of 3,5-diiodotyrosine was determined in euthyroid, hypothyroid and hyperthyroid individuals using a sensitive gas chromatographic mass spectrometric assay. This involved a multi-step extraction of the amino acid from urine (mean efficiency 28±5.7%) then conversion to the N,O -diheptafluorobutyryl methyl ester. The fragmentation of the derivative is discussed. Although the mean excretions in the two pathological states were significantly different from that of euthyroid individuals (P〈0.01 in both instances) there was considerable overlap with the normal range.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200100906
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  • 3
    Digitale Medien
    Digitale Medien
    Development of a gas chromatographic selected ion monitoring assay for thyroxine (T4) in human serum (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 421-427 
    Details
    ISSN: 0306-042X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The components of a gas chromatographic mass spectrometric-selected ion monitoring (SIM) assay for thyroxine (T4) in human serum are described. The internal standard for the assay was synthesized from deuterium-labelled 3,5-diiodotyrosine and 3,5-diiodo-4-hydroxyphenylpyruvic acid. A novel method was developed for isolating the products of the coupling reaction. The results obtained by gas chromatography mass spectrometry SIM were compared with those of radioimmunoassay. The gas chromatographic mass spectrometric SIM assay would form the basis of a reference assay for T4.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200110811
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  • 4
    Digitale Medien
    Digitale Medien
    Mass spectral properties of volatile derivatives of thyronine (To) and use of these in the study of thyronine excretion in Eu-, Hyper- and hypothroidism (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 193-198 
    Details
    ISSN: 0306-042X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The mass spectral properties of four classes of derivatives of thyronine are discussed (oxazolidinone, O-methyl oxazolidinone, O-acetyl oxazolidinone and N,O-diheptafluorobutyryl methyl ester). An assay for thyronine in human urine is described based on the N,O-diheptafluorobutyryl methyl ester. Results of To excretion in euthyroid humans were compared with those obtained previously using an assay based on the O-acetyl oxazolidinone derivative. Patients with frank hyperthyroidism had significantly higher To excretion than euthyroid subjects (2α 〈 0.002) and hypothyroid patients lower To excretions than enthyroid subjects (2α 〈 0.002). Some overlap between the two pathological ranges and the normal euthyroid range was evident.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200110411
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