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  • 1
    Electronic Resource
    Electronic Resource
    Fetal mouse weights and albumin/α1-fetoprotein ratios after maternal infection with Coxsackievirus B3 (1974)
    Springer
    Medical microbiology and immunology 159 (1974), S. 285-288 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The injection of pregnant mice with Coxsackievirus B3 results in a reduction of fetal weights and retarded development of the albumin/α1-fetoprotein ratio which can be measured by using the Laurell two-dimensional immunoelectrophoretic technique. The litter weights tended to be lower in litters with a low albumin/α1-fetoprotein ratio and from an analysis of covariance the results indicate that the effect of the virus on fetal weights can not all be accounted for by the effect on maturation. It is suggested that the mouse model system studied may be of value for demonstrating retarded fetal and neonatal maturation as a result of inapparent virus infection, and possibly from other causes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123738
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  • 2
    Electronic Resource
    Electronic Resource
    Measurement of free thyroid hormones in patients on long-term phenytoin therapy (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 633-634 
    Details
    ISSN: 1432-1041
    Keywords: phenytoin ; thyroid hormones ; thyroid function tests ; free thyroxine ; free triiodothyronine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Total thyroxine and triiodothyronine levels are often reduced in long-term phenytoin therapy, a finding at variance with the euthyroid clinical state of these subjects. We have measured free (biologically active) thyroid hormone levels in 31 patients on phenytoin therapy and have found a significant reduction in measurements of both free thyroxine and free triiodothyronine. In contrast, addition of phenytoin to normal serum in vitro resulted in an increase in free thyroxine and free triiodothyronine concentrations. The findings in vitro are consistent with displacement of thyroid hormones from thyroxine binding globulin while the reduced free hormone levels in vivo confirm that the effects of phenytoin are not confined to binding inhibition and suggest that phenytoin has induced a change in the cellular metabolism of thyroid hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543499
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  • 3
    Electronic Resource
    Electronic Resource
    Mitigation of virus-induced foetal growth retardation in mice by dietary casein hydrolysate (1975)
    [s.l.] : Nature Publishing Group
    Nature 254 (1975), S. 599-600 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Influence of dietary casein hydrolysate supplement on foetal development in mice infected with Coxsackievirus B3 Days of pregnancy Treatment No. of Maternal Total no. Total no. Foetal Foetal when casein animals weight of live of resorptions weight plasma hydrolysate ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/254599a0
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis and Nuclear Magnetic Resonance Spectroscopic, Mass Spectroscopic, and Plasma Amine Oxidase Inhibitory Properties of Analogues of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 50 (1988), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Seventeen analogues of l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine were synthesized using three reaction pathways: condensation of phenols with 1-methyl-4-piperidone, reaction of Grignard reagents with 1-methyl-4-piperidone followed by dehydration of the product, and aminomethylation of olefins. The identity of the products of synthesis was established by nuclear magnetic resonance spectroscopy, mass spectroscopy. and elemental analysis. Thirteen analogues were shown to inhibit the oxidation of benzylamine by bovine plasma amine oxidase. Increasing the length of the aliphatic chain of N-substituted analogues resulted in increased inhibition. In 4-phenyl-substituted analogues, both the position and electronic character of the substituent group affected the degree of inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb10578.x
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  • 5
    Electronic Resource
    Electronic Resource
    Retardation of Foetal Growth and Plasma Protein Development in Foetuses from Mice injected with Coxsackie B3 Virus (1973)
    [s.l.] : Nature Publishing Group
    Nature 241 (1973), S. 460-461 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Electrophoretic patterns of foetal and neonatal mouse sera. Disc gels of: a, 15 day foetus, control: non-infected; b, 18 day foetus, control: non-infected; c, 18 day foetus, infected: live virus; d, 18 day foetus, control: inactivated virus; e, 2 day neonate, control: non-infected; /, 2 day ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/241460a0
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  • 6
    Electronic Resource
    Electronic Resource
    3,5-diiodotyrosine excretion in human urine in individuals of differing thyroidal status (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1983), S. 507-511 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The urinary excretion of 3,5-diiodotyrosine was determined in euthyroid, hypothyroid and hyperthyroid individuals using a sensitive gas chromatographic mass spectrometric assay. This involved a multi-step extraction of the amino acid from urine (mean efficiency 28±5.7%) then conversion to the N,O -diheptafluorobutyryl methyl ester. The fragmentation of the derivative is discussed. Although the mean excretions in the two pathological states were significantly different from that of euthyroid individuals (P〈0.01 in both instances) there was considerable overlap with the normal range.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200100906
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  • 7
    Electronic Resource
    Electronic Resource
    Mass spectral properties of volatile derivatives of thyronine (To) and use of these in the study of thyronine excretion in Eu-, Hyper- and hypothroidism (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 193-198 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectral properties of four classes of derivatives of thyronine are discussed (oxazolidinone, O-methyl oxazolidinone, O-acetyl oxazolidinone and N,O-diheptafluorobutyryl methyl ester). An assay for thyronine in human urine is described based on the N,O-diheptafluorobutyryl methyl ester. Results of To excretion in euthyroid humans were compared with those obtained previously using an assay based on the O-acetyl oxazolidinone derivative. Patients with frank hyperthyroidism had significantly higher To excretion than euthyroid subjects (2α 〈 0.002) and hypothyroid patients lower To excretions than enthyroid subjects (2α 〈 0.002). Some overlap between the two pathological ranges and the normal euthyroid range was evident.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200110411
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  • 8
    Electronic Resource
    Electronic Resource
    Development of a gas chromatographic selected ion monitoring assay for thyroxine (T4) in human serum (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 421-427 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The components of a gas chromatographic mass spectrometric-selected ion monitoring (SIM) assay for thyroxine (T4) in human serum are described. The internal standard for the assay was synthesized from deuterium-labelled 3,5-diiodotyrosine and 3,5-diiodo-4-hydroxyphenylpyruvic acid. A novel method was developed for isolating the products of the coupling reaction. The results obtained by gas chromatography mass spectrometry SIM were compared with those of radioimmunoassay. The gas chromatographic mass spectrometric SIM assay would form the basis of a reference assay for T4.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200110811
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  • 9
    Electronic Resource
    Electronic Resource
    Mass spectrometric studies of thyroxine and related compounds. Trimethylsilyl derivatives (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 374-380 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of the trimethylsilyl derivatives of thyroxine and sixteen related compounds are reported. In addition to deiodinated analogues and iodinated tyrosines, the latter include a series of thyroacetic and thyropropionic acids and one thyroformic acid compound. Their spectra are discussed in terms of their fragmentation and utility for qualitative and quantitative estimation by gas chromatography - mass spectrometry.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010603
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