ISSN:
1432-1246
Schlagwort(e):
m-Xylene
;
Exercise
;
Psychophysiological functions
;
EEG
;
Man
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Eight male volunteers were exposed on 5 consecutive days and 1 day after the weekend to m-xylene vapour at either a constant (Study I) or a periodically varying (Study Il) concentration of 3.7–8.2 μmol/1(90–200 ppm, time-weighted average). The effects of the exposure on psychophysiological functions, such as reaction time, manual coordination and body balance, and EEG were studied. The same tests were completed on 2 non-exposure days for control purposes in both studies, in which physical exercise of 10O W was included. An inhalation exposure to m-xylene already at a concentration of 3.7 μmol/1 (90 ppm) had acute deleterious effects on the above mentioned psychophysiological functions of non-adapted subjects. EEG indicated lowered vigilance during exposure to varying concentrations with peak exposures of 8.2 μmol/l. Slight exercise, especially at the beginning of the exposure, seemed to antagonize the effects of xylene, particularly when the concentration fluctuated. Tolerance against the observed effects developed over one working week, but some effects were again discernible in the following week. A dose-response relationship between blood m-xylene concentrations and the effects of m-xylene was not found. This was probably due to tolerance.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01274130
Permalink
