ZIB

Treffer pro Seite

Treffer 1 - 2 | 2 Treffer

Sortierung

Digitale Medien

The effect of indomethacin on alveolar bone loss in experimental periodontitis (1982)

Weaks-Dybvig, Marilyn ; Sanavi, Farshid ; Zander, Helmut ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Journal of periodontal research 17 (1982), S. 0

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1600-0765

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: This study was undertaken to determine if prostaglandins play a role in the events leading to loss of bone in the ligature model of periodontitis. Periodontitis was induced by placement of the ligatures around mandibular teeth on one side of the jaw of squirrel monkeys (Saimiri sciureus). From one day prior to ligature placement, half the animals were administered indomethacin (5 mg/kg/day), a potent inhibitor of prostaglandin synthesis. Animals were sacrificed after one and two weeks of experimental periodontitis. It was found that indomethacin treatment abolished the significant losses of alveolar bone height and bone mass seen in non-indomethacin-treated (NIT) animals following ligature placement. Indomethacin also depressed the large increase in osteoclast density measured at one week in the NIT animals. The results support the hypothesis that prostaglandins are an important mediator of bone loss in the ligature model of periodontitis. Evidence is also presented for the coupling of bone resorption with osteoblastic neo-osteogenesis on both periodontal ligament and endosteal bone surfaces.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1600-0765.1982.tb01134.x

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Fine structure of fetal rat calvarium; provisional identification of preosteoclasts (1980)

Rifkin, Barry R. ; Brand, John S. ; Cushing, Janet E. ; [weitere]

Springer

Calcified tissue international 31 (1980), S. 21-28

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-0827

Schlagwort(e): Rat ; Calvarium ; Electron microscopy ; Preosteoclasts ; Osteoclasts

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin , Physik

Notizen: Summary This is a study of the fine structure of cells of the 20-day fetal rat calvarium. Special attention is given to identifying and characterizing preosteoclasts. These cells are relatively common and located largely, but not exclusively, at the endocranial bone surface. The preosteoclasts are characterized by abundant mitochondria, an incomplete perinuclear Golgi apparatus, and variable-shaped dense granules. The dense granules are unique in appearance in that they contain an internal dense matrix surrounded by a clear halo. Most granules are circular in shape but some are elongate or tubular in form. Granules with identical appearance are observed in osteoclasts. The preosteoclasts are mononucleate, or occasionally binucleate. It is suggested that because preosteoclasts are morphologically distinctive and relatively abundant, it should be feasible to separate these cells from a heterogeneous cell isolate.