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  • 1
    Electronic Resource
    Electronic Resource
    Murine model for pertussis vaccine encephalopathy: linkage to H – 2 (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 738-740 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] During a study of the effects of B. pertussis as an adjuvant in experimental allergic encephalomyelitis (EAE)7, we discovered a lethal shock-like syndrome in BALB/c mice after immunization with heat-killed B. pertussis vaccine and sensitiz-ation to bovine serum albumin (BSA). Heat-killed B. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299738a0
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  • 2
    Electronic Resource
    Electronic Resource
    Intrauterine multisystem atrophy in siblings: A new genetic syndrome? (1983)
    Springer
    Acta neuropathologica 61 (1983), S. 65-70 
    Details
    ISSN: 1432-0533
    Keywords: Cerebellum, hypoplasia ; Brain stem, hypoplasia ; Cerebral cortex, laminar atrophy ; Atrophy, multisystem ; Inheritance, autosomal recessive
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A condition is described in two siblings, dying in early infancy, characterized by an extreme degree of cerebellar hypoplasia, hypoplasia or atrophy of the brain stem with partial preservation of cranial and spinal nerve nuclei, total degeneration of basal ganglia and thalamus, laminar atrophy of the cerebral cortex, and accumulation of sudanophil lipid in astrocytes and macrophages of the hemispheric white matter. It is suggested that this condition, possibly inherited as an autosomal recessive, may represent a progressive multisystem atrophy occurring in utero, affecting various parts of the neuraxis in different stages in their development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688388
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  • 3
    Electronic Resource
    Electronic Resource
    Postictal cerebral hemiatrophy: With a contribution to the problem of crossed cerebellar atrophy (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 332-339 
    Details
    ISSN: 1432-0533
    Keywords: Epilepsy ; Cerebral hemiatrophy ; Crossed cerebellar atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case is presented of a 4.5-year-old child who died 5 days after the onset of a continuous hemiconvulsion and compared with three cases of established cerebral hemiatrophy. The laminar necrosis in the first case was strikingly similar in severity and distribution with the laminar cell loss in the others, thus producing additional evidence in support of the postictal aetiology of diffuse cerebral hemiatrophy. Particular attention was focussed on the pontocerebellar lesions. Three types of lesions were observed in the ipsilateral nuclei pontis: (1) focal neuronal necrosis in the acute stage, (2) focal neuronal loss, presumably the end result of the preceding lesion and (3) transneuronal atrophy. The contralateral cerebellar hemisphere showed the following abnormalities, singly or in combination: (1) necrosis of Purkinje cells in the acute stage, (2) loss of Purkinje cells and lobular sclerosis in advanced cases and (3) reduction in bulk of the hemisphere due to lesions in the nuclei pontis and degeneration of pontocerebellar fibres. These findings of the so-called crossed cerebellar atrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687616
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  • 4
    Electronic Resource
    Electronic Resource
    Crossed cerebellar atrophy: An old problem revisted (1982)
    Springer
    Acta neuropathologica 57 (1982), S. 197-202 
    Details
    ISSN: 1432-0533
    Keywords: Cerebellum, transneuronal degeneration ; Cerebellum, lobular sclerosis ; Hemiplegia, infantile ; Epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The problem of crossed cerebellar atrophy is re-examined in the light of an illustrative case, recent literature and the authors' previous experience. There types of lesions emerge from this analysis: (1) transneuronal atrophy of the nuclei pontis and contralateral middle cerebellar peduncle, (2) atrophy of nuclei pontis with secondary transneuronal degeneration of the granular layer of the cerebellar cortex, and (3) lobular sclerosis of the cerebellar folia of a postictal pattern. The pathogenesis of these lesions is discussed in the light of present-day concepts of transneuronal atrophy and degeneration and of the spread of the epileptic impulse. It is concluded that many cases of crossed cerebellar atrophy represent post-ictal and not transneuronal lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685389
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  • 5
    Electronic Resource
    Electronic Resource
    The structure of pseudomeissnerian corpuscles (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 174-176 
    Details
    ISSN: 1432-0533
    Keywords: Pseudomeissnerian corpuscles ; Neurofibroma ; Giant nevus ; Immunohistochemistry ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical staining for S-100 protein was carried out on one case of von Recklinghausen's neurofibroma and one of giant congenital nevus. Uniformly positive staining was ootained in all cells of the numerous pseudomeissnerian corpuscles in both cases. These structures thus appear, like the true Wagner-Meissner tactile nerve endings, to consist entirely of Schwann cells and not to contain any demonstrable perineurial component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697200
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  • 6
    Electronic Resource
    Electronic Resource
    Agenesis of the vermis with fusion of the cerebellar hemispheres, septo-optic dysplasia and associated anomalies (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 161-166 
    Details
    ISSN: 1432-0533
    Keywords: Malformations, cerebral ; Cerebellum, agenesis of vermis ; Cerebellum, fusion of hemispheres ; Septo-optic dysplasia ; Neurohypophysis agenesis ; Phencyclidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Agenesis of the cerebellar vermis with fusion of the dentate nuclei and cerebellar hemispheres (rhombencephalosynapsis) is a rare cerebral malformation. We report the case of a 7-h-old girl whose mother had taken the drug phencyclidine during the first 6 weeks of pregnancy. Absence of the septum pellucidum, hypoplasia of the commissural system, optic nerves, chiasm and tracts, moderate hydrocephalus, and agenesis of the posterior lobe of the pituitary were also found. Extracranial congenital anomalies involved the cardiovascular, respiratory, urinary, and musculoskeletal systems. Death was secondary to severe respiratory distress and bradycardia. The literature concerning this rare form of cerebellar malformation is reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690631
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