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  • 1980-1984  (11)
  • 1975-1979  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    EFFECTS OF 2-NICOTINAMIDOETHYL NITRATE (SG-75) ON PANCREATIC SECRETION IN THE ISOLATED, BLOOD-PERFUSED PANCREAS OF THE DOG (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of 2-nicotinamidoethyl nitrate (SG-75) on the secretion of pancreatic juice were compared with those of acetylcholine, secretin and pancreozymin in the isolated, blood-perfused dog pancreas.2. Intra-arterial administration of SG-75 (0.3-3 mg) elicited a dose-dependent increase in pancreatic secretion. Acetylcholine (10-100 μg), secretin (0.03-0.3 units) and pancreozymin (0.1-1.0 units) also elicited increased secretion.3. Secretory responses to acetylcholine were inhibited by treatment with atropine, while SG-75-, secretin-, and pancreozymin-induced secretions were not modified.4. Bicarbonate concentrations in pancreatic juice induced by SG-75 and secretin were increased in a dose-dependent manner. However, there were slight changes with acetylcholine or pancreozymin.5. Amylase activity in pancreatic juice was increased by SG-75, acetylcholine and pancreozymin, but was decreased by secretin.6. These results suggest that SG-75 stimulates pancreatic secretion by acting both on the acinar and ductular cells of the dog pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1981.tb00770.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECTS OF PROSTACYCLIN AND PROSTAGLANDIN E2 ON THE SECRETION OF PANCREATIC JUICE IN THE DOG (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1.Effects of prostacyclin (PGI2) and prostaglandin E2 (PGE2) on the secretion of pancreatic juice were investigated in preparations of the blood-perfused canine pancreas.3 These results suggest that PGE2, but not PGI2, may control the secretory mechanism of the pancreatic secretion in dogs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00823.x
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  • 3
    Electronic Resource
    Electronic Resource
    EFFECTS OF BROMOCRIPTINE ON PANCREATIC SECRETION IN THE ISOLATED, BLOOD-PERFUSED PANCREAS OF THE DOG (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of bromocriptine on the secretion of pancreatic juice were investigated with dog isolated, blood-perfused pancreas.2. Bromocriptine (1–10 mg) caused dose-dependent increases in the secretion of pancreatic juice. However, bromocriptine did not affect the perfusion blood flow rate. The secretory response to bromocriptine was inhibited by pretreatment with a dopamine antagonist, sulpiride, but not by phentolamine, propranolol, atropine, metiamide, indomethacin or tetrodotoxin.3. Bromocriptine caused a dopamine-like secretion of the pancreatic juice containing a high concentration of bicarbonate but had little effect on protein output.4. These results suggest that bromocriptine increases pancreatic secretion stimulating directly on pancreatic dopamine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00260.x
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  • 4
    Electronic Resource
    Electronic Resource
    ACTIVITIES OF NAD+-DEPENDENT ALDEHYDE DEHYDROGENASE AND ALCOHOL DEHYDROGENASE IN THE LIVER OF SPONTANEOUSLY HYPERTENSIVE RATS IN THE PROCESS OF DEVELOPMENT (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The difference in the basal activities of NAD+-dependent aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) was investigated in the liver of age-matched spontaneously hypertensive (SH) and normotensive Wistar Kyoto (WK) rats.2. A significant difference between the SH and WK rats in the basal ALDH activity, ADH activity and the protein content of subcellular fractions was observed. The activities of mitochondrial low Km- and high Km-ALDH in the SH rats at 5–8 weeks of age were higher than those in the WK rats. The microsomal high Km-ALDH activity in the SH rats at 5 and 11 weeks of age was higher than that in the WK rats. The ADH activities in the SH rats at 5–14 weeks of age were lower than those in the WK rats. The mitochondrial protein content in the SH rats at 5–14 weeks of age was higher than those in the WK rats.3. At 14 weeks of age, an increase in the blood acetaldehyde level was observed after an intraperitoneal injection of 1.5 g/kg of ethanol in the SH rats. No difference in blood ethanol level was observed between the SH and WK rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00257.x
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  • 5
    Electronic Resource
    Electronic Resource
    EFFECTS OF GLUCAGON ON PANCREATIC SECRETION IN THE DOG (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of glucagon on the secretion of pancreatic juice were investigated using blood-perfused canine pancreas preparations.2. Intravenous administration of glucagon (3–30 μg/kg) to the donor dog elicited a dose-dependent increase in pancreatic secretion. Intra-arterial administration of glucagon (10–100 μg) into the perfused pancreas also elicited increased secretion.3. There were slight increases in amylase concentration of the pancreatic juice with the largest doses of glucagon given by either route.4. Glucagon-induced secretion was not modified by treatment with phentolamine, propranolol, atropine, guanethidine, tetrodotoxin, haloperidol, prostaglandin F2a or calcitonin.5. The results suggest that glucagon acts directly on the exocrine cells of the canine pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00591.x
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  • 6
    Electronic Resource
    Electronic Resource
    EFFECTS OF CALCITONIN ON THE SECRETION OF PANCREATIC JUICE INDUCED BY DOPAMINE, SECRETIN AND PANCREOZYMIN (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of calcitonin on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated blood-perfused canine pancreas.2. The volume of pancreatic secretion induced by pancreozymin given intra-arterially (i.a.) was decreased by an i.a. infusion of 1 u/min of calcitonin, but that induced by dopamine or secretin given i.a. was not affected by calcitonin treatment.3. Amylase concentration in pancreatic juice either in spontaneous secretion in the resting state or in that of stimulated secretion by pancreozymin was decreased approximately 30% by calcitonin treatment, but amylase concentration in pancreatic juice induced by dopamine or secretin was not affected by calcitonin treatment.4. Calcitonin had no effect on bicarbonate concentration in pancreatic juice stimulated by these secretagogues.5. Calcium concentration in pancreatic juice in the resting state was reduced about 36% by calcitonin treatment. Calcitonin caused a decrease in a calcium concentration in the pancreozymin-induced secretion, but did not cause any change in the dopamine- or secretin-induced one.6. These results suggest that calcitonin may affect the secretory mechanism of the acinar cells but not that of the ductular cells, and that the acinar cells are active even in the resting state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00600.x
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  • 7
    Electronic Resource
    Electronic Resource
    EFFECTS OF VERAPAMIL ON PANCREATIC EXOCRINE SECRETION INDUCED BY DOPAMINE, SECRETIN AND PANCREOZYMIN IN THE DOG (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of verapamil on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated, blood-perfused canine pancreas in vivo.2. The volume of pancreatic secretion either in the resting state or induced by pancreozymin given intra-arterially (i.a.) was decreased by an infusion of 5 μg/min of verapamil; that induced by dopamine or secretin i.a. was also decreased but the changes were not statistically significant.3. Protein concentration in pancreatic juice either in the resting state or in that of stimulated secretion by pancreozymin was decreased significantly, but protein concentration induced by dopamine or secretin was not affected, by verapamil treatment.4. Verapamil had no effect on bicarbonate concentration in pancreatic juice secreted either in the resting state or when stimulated by these secretagogues.5 These results suggest that verapamil, at least in part, may affect the secretory mechanisms of acinar cells but not that of the ductular cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00793.x
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  • 8
    Electronic Resource
    Electronic Resource
    EFFECTS OF NICARDIPINE ON PANCREATIC EXOCRINE SECRETION IN THE DOG (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of nicardipine on the secretion of pancreatic juice were investigated in dog isolated, blood-perfused pancreas, and compared with those of papaverine, aminophylline and secretin.2. Intra-arterial administration of nicardipine (1-10 μg) elicited a dose-dependent increase in pancreatic secretion. Papaverine (0.1-1 mg), aminophylline (0.3-3 mg) and secretin (0.03-0.1 units) also elicited increased secretion. The secretory activity of nicardipine (10μg) was approximately equal to that of 0.5 mg of papaverine, 1.5 mgof aminophylline and 0.03 units of secretin.3. The concentration of bicarbonate in the pancreatic juice induced by nicardipine was increased, but the protein concentration was only increased slightly. These effects are analogous to those of secretin.4. Nicardipine-induced secretion was not modified by pretreatment with relatively large doses of phentolamine, propranolol, atropine, guanethidine, haloperidol or metiamide.5. Secretin-induced secretion was significantly potentiated by infusion of papaverine, but not by infusion of nicardipine or aminophylline.6.These results suggest that nicardipine acts on the exocrine cells in the dog pancreas, at least in part, through the increase of intracellular cyclic AMP concentration by inhibiting phosphodiesterase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00829.x
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  • 9
    Electronic Resource
    Electronic Resource
    SECRETORY AND VASCULAR EFFECTS OF THE OPTICAL ISOMERS OF NICARDIPINE (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of optical isomers of nicardipine on the secretion of pancreatic juice and blood flow were investigated in the dog-isolated, blood-perfused pancreas.2. Intra-arterial administration of (-)-nicardipine (10–300 μg) caused a dosedependent increase in pancreatic secretion. However, the (+)-isomer was much less potent than the (-)-isomer and even in 300 μg of (+)-isomer caused only a slight secretion.3. (+)- And (-)-nicardipine increased perfusion blood flow in a dose-dependent manner, and (+)-nicardipine was approximately five times as potent as the (-)-isomers. The maximum increase in a flow rate was produced by 30 μg of (+)-isomer and 100 μg of (-)-isomer.4. Bicarbonate concentration in pancreatic juice induced by (-)- and (+)-nicardipine was increased in a dose-dependent manner, but the protein concentration was only increased slightly.5. From these results, it is concluded that there is a stereoselectivity in the secretory and vascular actions of optical isomers of nicardipine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00233.x
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  • 10
    Electronic Resource
    Electronic Resource
    Mechanisms of pustule formation in cutaneous bacterial and viral infections: alterations of neutrophil membrane surface receptors (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 110 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Changes in membrane surface receptors have been demonstrated by rosetting methods in polymorphonuclear leukocytes obtained from the pustules of different infectious dermatoses. There was a distinct difference in numbers of receptors in neutrophils from bacterial and viral pustules, i.e., C3b receptors were decreased on neutrophils from both bacterial and viral pustules, whereas IgG-Fc receptors were decreased only in neutrophils from viral pustules. The difference appears to be due to variations in the defence mechanisms against the invading micro-organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb07460.x
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