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Digitale Medien

Insulin, S-sulphonate A and S-sulphonate B-chain receptor binding to human cultured lymphocytes (1977)

Kobayashi, M. ; Meek, J. C.

Springer

Diabetologia 13 (1977), S. 251-255

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Details

ISSN: 1432-0428

Schlagwort(e): Insulin receptor ; cultured lymphocytes ; insulin structure function relationship ; insulin chains

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The ability of insulin and the S-sulphonate A and B-chain derivatives to bind to a receptor on cultured human lymphocytes was evaluated. A receptor site for the S-sulphonate A-chain was identified and was strongly influenced by the intact insulin molecule. S-sulphonate A-chain weakly interfered with insulin binding. S-sulphonate B-chain showed no evidence of significant binding and did not interfere with insulin or S-sulphonate A chain binding.14CO2 production from14C-1-glucose was stimulated by insulin in cultured lymphocytes and this effect was blunted by S-sulphonate A-chain. The sulphhydryl blocking agent used in the production of insulin A-chain appears to be of critical importance.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01219708

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