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  • 1
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of chlormethiazole following intravenous administration in the aged (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 407-415 
    Details
    ISSN: 1432-1041
    Keywords: Chlormethiazole pharmacokinetics ; elderly human subjects ; disposition half-life ; plasma clearance ; blood/plasma concentration ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight healthy aged subjects were administered 1.2 g of chlormethiazole by constant-rate intravenous infusion. The disposition of the drug was found to be multi-exponential in character. Fits of plasma level-time data to two- and three-compartment open models were assessed with the aid of statistical tests. For three of the subjects the experimental data were adequately fitted to a two-compartment pharmacokinetic model, however a three-compartment model was necessary to fit the data observed for a further four subjects. An anomalous chlormethiazole plasma concentration-time curve was obtained for the remaining subject. The disposition half-life of chlormethiazole was 8.49±3.28 h and the plasma clearance was 16.14±5.00 ml/min/kg. These values were significantly different to those reported earlier for young adult subjects and the clinical implications have been discussed. The blood/plasma concentration ratio of chlormethiazole was found to be approximately one with some evidence for concentration dependence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563077
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  • 2
    Electronic Resource
    Electronic Resource
    Fluorescence lifetimes in the photosynthetic unit (1975)
    [s.l.] : Nature Publishing Group
    Nature 258 (1975), S. 166-168 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The first laser pulse measurements on picosecond fluorescence lifetimes used the electro-optical shutter3"5 but the irreproduci-bility of pulse intensity makes this a rather imprecise method. The streak camera6-7 has greatly improved the precision but much of this is lost if photographic recording ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/258166a0
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  • 3
    Electronic Resource
    Electronic Resource
    Myocardial Dysfunction and Pathology Associated with Environmental Stress in Squirrel Monkey: Effect of Vagotomy and Propranolol (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 16 (1979), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: The influence of autonomic innervation on stress-induced cardiomyopathy and heart rate changes was analyzed by selective removal of parasympathetic and sympathetic myocardial inputs. Squirrel monkeys with bilateral cervical vagotomy or β-adrenergic receptors blocked by propranolol were studied in shock stress and restraint situations. Because propranolol reduced stress-induced lesions and tachycardia, enhanced sympathetic β-receptor activity was considered responsible for these effects in intact monkeys. No role for increased parasympathetic activity in myocardial pathology was indicated. Enhanced sympathetic activity was also implicated by lesions and tachycardia of vagotomy monkeys. However, vagotomy alone induced myocardial pathology and confounded the effects of shock stress. Stress-induced cardiac arrest in both vagotomy and propranolol monkeys was observed. An imbalance of either autonomic input was suggested to be responsible for this dysfunction. Thus, autonomic innervation was involved in stress-induced cardiomyopathy and heart rate changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1979.tb01520.x
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  • 4
    Electronic Resource
    Electronic Resource
    Myocardial Degeneration and Cardiac Arrest in Squirrel Monkey: Physiological and Psychological Correlates (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Psychophysiology 14 (1977), S. 0 
    Details
    ISSN: 1469-8986
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Behavioral factors and cardiovascular changes associated with myocardial degeneration and cardiac arrest induced by shock avoidance stress were studied. Pairs of avoidance and yoked squirrel monkeys were exposed to a 24-hr session. Myocardial degeneration and cardiac arrest were more readily induced in avoidance than yoked monkeys. The cardiac lesions were not related to body weight, aggressive behavior, or number of shocks received during stress, but an increased heart rate without hypertension during the first stress hour was more evident in avoidance than yoked monkeys. These cardiac changes were attributed to an autonomic disturbance associated with the response contingencies of the avoidance situation. An autonomic effect also appeared to be involved with stress-induced death. These deaths were characterized by a sudden, severe bradycardia without initial hypotension and cardiac arrest which was attributed to either parasympathetic activation or sympathetic inhibition. While heart rate decreased in all monkeys, stress-induced death followed only in monkeys which gave up and stopped contending with the stress. Thus, stress-induced myocardial changes and death were related to autonomic disturbances precipitated by psychological stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-8986.1977.tb01186.x
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  • 5
    Electronic Resource
    Electronic Resource
    An initial survey of a wreck, thought to be a St Malo vessel, the Marguerite, sunk in 1707 at Conche, Newfoundland (1979)
    Oxford, UK : Blackwell Publishing Ltd
    The @international journal of nautical archaeology 8 (1979), S. 0 
    Details
    ISSN: 1095-9270
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Archaeology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-9270.1979.tb01097.x
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  • 6
    Electronic Resource
    Electronic Resource
    Uptake and Distribution of Mercury within Higher Plants (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 39 (1977), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The uptake and distribution of inorganic mercury (HgCl2) within higher plants (Pisum sativum and Mentha spicata) was examined using solution culture and radiotracer techniques. Plants were found to tolerate an external level of 1 mgHg/kg of solution but both physiological and biochemical processes were affected at 5 mgHg/kg and 10 mgHg/kg. The uptake of Hg into plants grown in hydroponic solution was a function of external concentration. Over the concentration range considered the accumulation of Hg in the roots was linear on a log-log basis although the uptake of the element into the shoots appeared to be two-phased. The distribution of Hg in plants was asymmetrical with much greater amounts of the element in the roots than the shoots. Although the level of Hg increased generally in plant tissues with increasing external levels, the proportion retained in the roots, relative to the shoots, was constant (approximately 95%). Two binding characteristics of the Hg within plant tissue were detected. A major proportion of Hg was tightly bound, being unaffected by treatment with ethanol and hydrochloric acid. The remaining Hg in the tissue was removed by either water or hydrochloric acid treatment. Cell fractionation indicated that the major binding component of Hg in plant tissues was the cell wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3054.1977.tb01880.x
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  • 7
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    Unknown
    Gerson, L. D. "The Secret Police in Lenin's Russia" (Book Review) (1978)
    London, etc. : Periodicals Archive Online (PAO)
    Slavonic and East European review. 56:1 (1978:Jan.) 140 
    Details
    ISSN: 0037-6795
    Topics: History , Slavonic Studies
    Notes: REVIEWS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0072-1978-056-01-000026
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  • 8
    Electronic Resource
    Electronic Resource
    Adhesive contact during the oblique impact of elastic spheres (1979)
    Springer
    Zeitschrift für angewandte Mathematik und Physik 30 (1979), S. 468-476 
    Details
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Description / Table of Contents: Résumé On établit une représentation intégrale de la distribution de traction tangentielle pendant le contact adhésif entre deux sphères de matériaux élastiques similaires chargées obliquement. On démontre que des conditions adhésives s'établisseut au commençement d'un choc entre deux sphères aux petits angles d'incidence ou après une période initiale de glissement aux angles plus grands. Une équation différentielle décrivant cette phase du choc est élaborée et résolue.
    Notes: Abstract An integral representation is developed for the distribution of tangential traction during adhesive contact between obliquely loaded elastic spheres of similar materials. It is shown that adhesive conditions arise at the beginning of an impact between two spheres at low angles of incidence or after an initial period of gross slip for larger angles. A differential equation is developed and solved, describing this phase of the impact.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01588891
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of heat flow on the contact area between a continuous rigid punch and a frictionless elastic half-space (1976)
    Springer
    Zeitschrift für angewandte Mathematik und Physik 27 (1976), S. 439-445 
    Details
    ISSN: 1420-9039
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Description / Table of Contents: Résumé On donne une preuve générale du théorème que, si un poinçon continu rigid, pénétrant un demi-espace élastique, est chauffé, la séparation des solides grandira et une partie de la région de contact sera perdue. On montre également que la région de contact ne peut pas être multiplement connexe si le poinçon est convexe.
    Notes: Abstract A general proof is given of the theorem that, if a continuous rigid punch indenting an elastic half space is heated, the separation of the solids will increase and part of the contact area will be lost. It is also shown that if the punch is convex, the contact area cannot be multiply-connected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01594900
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  • 10
    Electronic Resource
    Electronic Resource
    Photosynthesis at Reading (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 104-105 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Fourth International Congress on Photosynthesis was held at Reading on 4-9 September, 1977. The Congress dealt with all aspects of research into photosynthesis under two broad categories; the light reactions, and carbon metabolism (including the physiological and applied aspects of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270104a0
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