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  • 1
    Electronic Resource
    Electronic Resource
    Übersichtsspektren von Urinproben im Ablauf von hämolytisch-urämischen Syndromen (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 855-856 
    Details
    ISSN: 1432-1440
    Keywords: Haemolytic uraemic syndrome (HUS) ; Isotachophoresis ; HUS specific substance ; Hämolytisch-urämisches Syndrom ; Isotachophorese ; HUS-spezifische Substanz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In 29 Urinfraktionen von sechs Kindern mit hämolytisch-urämischem Syndrom (HUS) wurde in der akuten Phase der Krankheit mittels analytischer Isotachophorese eine spezifische Substanz nachgewiesen. Die Urine von sechs nierenkranken Kontrollpersonen und sieben Gesunden wiesen diese Substanz nicht auf. Es wird angenommen, daß die im Isotachogramm registrierte Substanz in direkter Beziehung zu dem Krankheitsbild des HUS steht.
    Notes: Summary In 29 urinary fractions of six children with haemolytic uraemic syndrome (HUS) a specific substance could be demonstrate during the acute phase of the disease by means of isotachophoresis. Urine tests in six patients with other kidney diseases and with uraemia and in seven healthy persons did not show this substance. From this, we assume that the substance demonstrated in the isotachogram has a direct correlation to the HUS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477992
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro studies of bone marrow stem-cell function in uraemic children (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 279-284 
    Details
    ISSN: 1432-1076
    Keywords: Human CFU-E ; Human CFU-C ; Bone marrow culture ; Erythropoiesis ; Granulopoiesis ; Renal anaemia ; Uraemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anaemia is a frequent symptom in children with chronic uraemia. There is only limited information about committed haemopoietic stem-cell function in renal insufficiency. The ability of bone-marrow cells to form erythropoietic and granulopoietic cell colonies in vitro was therefore tested in 13 children with chronic renal insufficiency. Following separation of mononuclear cells from bone-marrow aspirates by Ficoll-Isopaque gradient centrifugation, erythropoietic precursor cells were stimulated in plasma clots by erythropoietin. Granulopoietic precursor cells were stimulated in soft-agar gel using feeder layers of normal human leukocytes. The colonies were identified by staining and counted. The number and proliferative capacity of erythropoietic precursor cells (CFU-E) did not seem to be significantly suppressed. Under in vitro conditions, the responsiveness of CFU-E to erythropoietin seemed to be normal. Addition of autologous serum resulted in different degrees of inhibition of erythroid colony formation. The inhibitory effect of the sera was also obvious when uraemic sera were added to bone-marrow cells from subjects without renal disease. Preliminary data indicate that haemodialysis is effective in reducing this inhibitory activity which may be an important factor in the pathogenesis of anaemia in chronic renal insufficiency. The numbers and proliferative capacity of granulopoietic precursor cells (CFU-C) were normal in all the children tested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441359
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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