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  • 1975-1979  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Ethanol and tolerated doses ofAmanita phalloides protect against lethal doses of the mushroom (1977)
    Springer
    Inflammation research 7 (1977), S. 171-173 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single tolerated doses of a lyophilizate fromAmanita phalloides (APL) failed to increase the survival rate of mice after the LD90 of the mushroom. Also, pretreatment with large doses of ethanol did not protect against lethal doses of APL. However, with combined administration of single tolerated doses of APL and of ethanol, the survival rate of mice after a lethal challenge with APL was increased from 13% to up to 100%. Both ethanol and APL potentiated the effect of barbiturate narcosis, but the combined pretreatment was not more effective. The protection against APL afforded by the combined regimen may be due to inhibition of activating hepatic microsomal enzymes, but biochemical studies are needed to support this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964916
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Protection by phalloidin against lethal doses of phalloidin (1976)
    Springer
    Inflammation research 6 (1976), S. 490-492 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tolerated doses of phalloidin, a toxin from the mushroomAmanita phalloides, protect mice against lethal doses of phalloidin. Resistance is conferred by the 1/10 LD95 of phalloidin and sets in at about 8 hours after the pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973265
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Antagonistic effects against single lethal doses of Amanita phalloides (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 293 (1976), S. 171-174 
    Details
    ISSN: 1432-1912
    Keywords: Amanita phalloides ; Mushroom ; Poisoning ; Antidotes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Agents with antagonistic effects against phalloidin or α-amanitin were tested in mice against lethal doses of an extract from the whole mushroom amanita phalloides. The following categories of agents reduced lethality after the extract. First, agents protecting only against phalloidin such as rifampicin, phenylbutazone and antamanide. Second, silymarin and prednisolone which display both antiamatoxic and marked (silymarin) or moderate (prednisolone) antiphallotoxic activity. Thioctic acid displayed some activity when tested against mid-lethal doses of the extract. Cytochrome c, a chemical with curative potencies against α-amanitin did not reduce the lethality of the extract. All of the effective agents acted only when applied prior to the poisoning. The pattern or protective activity would indicate that in mice death after single doses of Amanita phalloides may follow a qualitatively particular course which is difficult to ascribe to phallo- or amatoxic effects alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499223
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    Paper (German National Licenses)
    Fulltext
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