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  • 1
    Electronic Resource
    Electronic Resource
    Ethanol and tolerated doses ofAmanita phalloides protect against lethal doses of the mushroom (1977)
    Springer
    Inflammation research 7 (1977), S. 171-173 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single tolerated doses of a lyophilizate fromAmanita phalloides (APL) failed to increase the survival rate of mice after the LD90 of the mushroom. Also, pretreatment with large doses of ethanol did not protect against lethal doses of APL. However, with combined administration of single tolerated doses of APL and of ethanol, the survival rate of mice after a lethal challenge with APL was increased from 13% to up to 100%. Both ethanol and APL potentiated the effect of barbiturate narcosis, but the combined pretreatment was not more effective. The protection against APL afforded by the combined regimen may be due to inhibition of activating hepatic microsomal enzymes, but biochemical studies are needed to support this hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964916
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  • 2
    Electronic Resource
    Electronic Resource
    Protection by phalloidin against lethal doses of phalloidin (1976)
    Springer
    Inflammation research 6 (1976), S. 490-492 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tolerated doses of phalloidin, a toxin from the mushroomAmanita phalloides, protect mice against lethal doses of phalloidin. Resistance is conferred by the 1/10 LD95 of phalloidin and sets in at about 8 hours after the pretreatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973265
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  • 3
    Electronic Resource
    Electronic Resource
    Ethanol diminishes the toxicity of the mushroomAmanita phalloides (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1268-1270 
    Details
    ISSN: 1420-9071
    Keywords: Mushroom poisoning ; Amanita phalloides ; ethanol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Survival of mice after lethal doses of a lyophilizate fromAmanita phalloides (‘death cap’) was markedly increased by single doses of ethanol applied 30 min before or 5 min after the mushroom. Hepatic histopathological damage (confluent necrosis) was largley prevented. Acute, but not chronic, consumption of ethanol may thus influence favorably the outcome of death cap poisoning and should be taken into consideration in the evaluation of therapeutic measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946668
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of zinc, D-penicillamine and oxygen on poisoning withAmanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom (1984)
    Springer
    Inflammation research 14 (1984), S. 124-130 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroomAmanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight.d-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966845
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  • 5
    Electronic Resource
    Electronic Resource
    Curative potencies of penicillin in experimental amanita phalloides poisoning (1971)
    Springer
    Inflammation research 2 (1971), S. 138-141 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Some lethal factors of the toadstool, once absorbed, may still be antagonized. Penicillin displayed such antidotal potencies in rats and mice. Its effect was the more pronounced the greater the dose and the sooner its application after onset of poisoning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966752
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  • 6
    Electronic Resource
    Electronic Resource
    Antiarthritic and immunosuppressive effects of Pseudomonas aeruginosa (1972)
    Springer
    Inflammation research 2 (1972), S. 231-235 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fractions obtained from Pseudomonas aeruginosa suppressed microcrystal synovitis in pigeons, adjuvant arthritis and experimental allergic encephalomyelitis in rats, the tuberculin reaction in guinea-pigs and the homograft reaction and antibody formation in mice. Products of gram-negative bacteria thus impair nonimmunological inflammatory processes as well as in vivo manifestations of immune-mediated reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087047
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  • 7
    Electronic Resource
    Electronic Resource
    System for the Recognition of Genetic Transformation in Hæmopoietic Cells (1962)
    [s.l.] : Nature Publishing Group
    Nature 193 (1962), S. 1266-1268 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ALTHOUGH genetic transformation in bacteria /~\ by deoxyribonucleic acid (DNA) has been known for a considerable time1, no conclusive evidence of its occurrence in mammalian cells has been recorded so far. A more complex chromosomal reproductory mechanism might be a barrier for its analogy in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1931266b0
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of Methylhydrazine Derivatives on the Survival of Second-set Skin Homografts (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 638-639 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Inbred strains of mice were used. Skin grafting was done by the method of Billingham and Medawar5. Grafts were taken from the general body skin of donors. The dressings were removed on the sixth day and the grafts were inspected daily thereafter. The survival times were taken as end points, that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211638a0
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  • 9
    Electronic Resource
    Electronic Resource
    Medikamente für die Organtransplantation (1968)
    Springer
    Langenbeck's archives of surgery 322 (1968), S. 470-475 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die heute gebräuchlichen chemischen Immunosuppressiva sind in einer Dosis, welche die Abstoßungsreaktion in praktisch allen Fällen unterdrückt, nicht mehr für alle Patienten verträglich. Die Nachteile, die diesen Mitteln vorläufig noch anhaften, bestehen in ihrer mangelnden Elektivität, d. h. allgemeine Cytotoxicität und allgemeine Immunosuppression statt gezielter Hemmung der Transplantationsimmunität. Dennoch ist dank dieser Mittel die Organtransplantation in ihrem heutigen Ausmaß und Gelingen möglich geworden.
    Notes: Summary The immunosuppressive chemicals which are in use at present, when given in a dosage that will suppress rejection in practically every case, will not be tolerated by all patients. The drawback attached to these drugs for the time being is a lack of selectivity, that is a generalized cytotoxicity and immunosuppressive action instead of restricted inhibition of transplantation immunity. In spite of these imitations it is these drugs which made the success of organ transplantation possible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02453864
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  • 10
    Electronic Resource
    Electronic Resource
    Verlängerte Überlebenszeit von Hauthomotransplantaten bei Mäusen durch ein Methylhydrazinderivat (1963)
    Springer
    Cellular and molecular life sciences 19 (1963), S. 546-547 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Extended survival of skin homografts in mice was obtained by treatment with a methylhydrazine derivative (1-methyl-2-p-(isopropylcarbamoyl)-benzylhydrazine hydrochloride), representative of a new class of cytotoxic agents. Administration of 100 mg/kg prior to and continuously after the transplantation led to similar survival times as when 300 mg/kg was given daily only after the transplantation. In mice, the compound seems to be more effective than most of the drugs so far known to suppress transplantation immunity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150908
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