ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Swiss mice were protected from lethal doses of phalloidin by phenylbutazone and rifampicin. The former as well as sulfadimethoxine and Bactrim® (sulfamethoxazole+trimethoprim) were also prophylactically active against poisoning by an extract prepared from the whole mushroom Amanita phalloides. Penicillin and phenylbutazone displayed curative effects against the extract in MAG mice. Protection against α-amanitin was provided in Swiss mice by phenylbutazone, aminopyrine, penicillin, chloramphenicol, sulfadimethoxine and Bactrim®. Combined treatment, including especially Bactrim®, penicillin and chloramphenicol, afforded in general greater antagonistic activity. The hypothesis is presented that these heterogenous agents compete with α-amanitin for its serum albumin binding sites. By displacing α-amanitin from proteins, its renal excretion is thought to be enhanced and its serum concentration reduced in time to prevent irreversible liver cell injury.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01966753
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