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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The β-adrenergic agonist, isoproterenol and the α- and β-adrenergic agonist. NA. raise the intracellular concentration of cyclic AMP in cultures of dissociated perinatal mouse brain. This rise is prevented by a β- but not by an α-adrenergic antagonist. The maximal level of cyclic AMP reached in the presence of isoproterenol is markedly higher than that found after exposure to NA. However, if NA is used along with an α-adrenergic antagonist, cyclic AMP levels as high as those after isoproterenol are measured. Agonists with α-adrenergic activity including NA decrease the response to isoproterenol. The decrease is blocked by α-adrenergic antagonists. From this and additional evidence it is concluded: (1) The increase in the level of cyclic AMP caused by β-adrenergic agonists is due to β-receptor-mediated stimulation of adenylate cyclase; (2) the inhibition of this effect by α-adrenergic agonists is mediated by adrenergic α-receptors; (3) the α- and β-adrenergic receptors are likely to be located on the same cells, probably the most abundant putative glial precursor cells. The simultaneous stimulation of α- and β-adrenergic receptors on the same cell may be of significance in the regulation of the response to NA.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 44 (1979), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The study was undertaken to determine the amount and nature of condensed tannins in rapeseed meal. No condensed tannins were found in rapeseed meats (endosperm plus germ). The hulls, however, yielded 0.1% condensed tannins by 70% aqueous acetone extraction, the bulk of the condensed tannins in the hulls being unextractable by the extractants used. The basic unit of the isolated polymeric flavanols appeared to be leucocyanidin.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 32 (1976), S. 618-626 
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Neutron diffraction has been used to study the structural disorder in γ-CuCl at 25 and 366°C. Powder patterns of 63CuNCl, NCuNCl and 65CuNCl (N= natural abundance) were treated by integrated intensity (II) and radial density (RD) analyses. Using II, a satisfactory fit to these 366°C data was made with the anharmonic model described by Sakata, Hoshino & Harada [Acta Cryst. (1974). A30, 655-661]. This fit resulted in an anharmonic parameter βCu = 1.2 ± 0.6 × 10-12 erg Å-3, which is in excellent agreement with the value of βCu = 1.15 ± 0.66 × 10-12 erg Å-3 obtained from a single-crystal study at room temperature by Sakata et al. (1974). To eliminate the indistinguishability of the anharmonic and statistically disordered models inherent in II, an energy analysis was made of the diffuse scattering. It was found that at 25 °C, 50 to 70% of the diffuse scattering is elastic. The non-monotonic κ dependence of this elastic diffuse scattering implies a model of correlated static displacements of Cu atoms and is inconsistent with the anharmonic model. Radial density analyses of the three spectra were fitted to a model based on harmonic vibration to obtain partial radial densities QCuCu,QClCl and QCuCl,. Although theQClCl, was typical of that expected for a solid structure, QCuCu,, at 366°C was found to be more 'liquid-like'. Quantitative conclusions from this radial density analysis are limited by the strong dependence of the results on instrumental resolution. An estimate of the effect of instrumental resolution on the measured radial density function is contained in Appendix B.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 35 (1979), S. 2473-2475 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 10 (1977), S. 79-83 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The superconductor Th4D15 has been investigated by neutron diffraction with the spallation neutron source (ZING-P) at Argonne National Laboratory. Profile refinement of the powder data for d spacings between 0.65 and 1.95 Å, corresponding to a neutron wavelength range of 1.26–3.77 Å, confirms the structure suggested by Zachariasen [Acta Cryst. (1953), 6, 393–395]. The b.c.c. cell, I\bar 43 d (a0 = 9–11 Å), of Th4D15 contains 16 Th atoms at 16(c) [xTh = 0.2066 (3)] and 60 D atoms at 12(a) and 48(e) [x = 0.3706 (7), y = 0.2155 (7), and z = 0.4048 (7)]. The Th atoms are equally spaced (3.95 Å) along four non-intersecting chains that are parallel to the four body diagonals. The general position D atoms, 48(e), form small equilateral triangles along the chains approximately equidistant from each Th atom. Neighboring triangles along a chain are rotated ±19.5 (2.0)° with respect to each other. The D atoms at 12(a) are centered in near-regular tetrahedra of Th atoms, consisting of one member from each chain and sharing only corners with adjacent tetrahedra. Each Th atom is found in a cage of three 12(a) plus nine 48(e) D atoms. Results for Debye–Waller factors of the Th and D atoms at 295 and 92 K are presented and compared with values obtained for the Debye–Waller factors in Pd–H.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 38 (1979), S. 447-455 
    ISSN: 1432-0584
    Keywords: Lymphozyten ; Purinstoffwechsel ; Adenin ; Guanin ; Hypoxanthin ; Lymphocytes ; Purine metabolism ; Adenine ; Guanine ; Hypoxanthine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In peripheral human blood lymphocytes the uptake and metabolism of adenine, guanine, and hypoxanthine was investigated. This was achieved by incubation of purified lymphocytes with14C-purine bases, separation of cells from the incubation medium by a rapid filtration technique, and subsequent separation of the acid soluble material by thin-layer chromatography. No preferential uptake for one of the purine bases was observed. In all cases only traces of14C-purine bases not added originally and labeled nucleosides could be demonstrated. Approximately 2/3 of adenine and 1/2 of guanine or hypoxanthine were converted to nucleotides. Separation of formed nucleotides showed that adenine and guanine were metabolized mainly to their corresponding nucleotides; hypoxanthine was converted to a considerable amount to adenine nucleotides and only to a small proportion into its own nucleotides. These results demonstrate the predominance of adenine nucleotide formation in normal human lymphocytes.
    Notes: Zusammenfassung In peripheren menschlichen Lymphozyten wurden die Aufnahme und der Stoffwechsel von Adenin, Guanin und Hypoxanthin untersucht. Die gereinigten Lymphozyten wurden mit14C-markierten Purinbasen inkubiert und anschlie\end vom Inkubationsmedium mittels rascher Filtrationstechnik getrennt. Eine bevorzugte Aufnahme einer der Purinbasen konnte nicht beobachtet werden. Die dünnschichtchromatographische Auftrennung der säurelöslichen Metabolite ergab kaum eine Bildung von Nukleosiden und anderen als den zugesetzten Purinbasen. Adenin wurde zu ca. 2/3, Guanin und Hypoxanthin hingegen zu etwa der Hälfte zu Nukleotiden aufgebaut, wobei Adenin und Guanin hauptsächlich zu ihren eigenen, Hypoxanthin jedoch zu Adeninnukiektiden metabolisiert wurde. Die Ergebnisse weisen auf die bevorzugte Bildung von Adeninnukleotiden in normalen menschlichen Lymphozyten.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 224 (1977), S. 246-247 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Microchimica acta 72 (1979), S. 389-396 
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Anwendung der genannten Verfahren wurde beschrieben. Minimaler Zeitaufwand und Probenverbrauch sind die Vorteile dieser Verfahren, da keine Derivatisierung erforderlich ist. Bei der Pyrolyse/Massenspektrometrie bildet der am C2 gebundene Substituent ein größeres thermisches Spaltprodukt, das den Typus des Anthocyans kennzeichnet. Glykoside und Aglykone sind ebenfalls leicht zu unterscheiden.
    Notes: Summary The use of pyrolysis mass spectrometry and pyrolysis-GC/mass spectrometry is described for the identification of anthocyanins. Minimal time and sample consumption are the advantages of the method, as no derivatization is requested. In pyrolysis mass spectrometry the substituent at carbon two gives rise to a major thermal fragment that is representative for the type of anthocyanin. Glycosides and aglycones are also easily differentiated.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The purification of anti-BPO-antibodies and anti-BPO-IgG resp. by means of affinity chromatography is being described. The immunosorbent was prepared by direct covalent coupling of BPO groups to AH-Sepharose 4B beads. The antibodies were linked to the immunosorbent in a batch and eluted by stepwise chromatography. The hapten density of the gel was very high (3.6×10−5 mole BPO/1 g Sepharose 4B) as could be demonstrated by application of14C-penicillin-potassium. Good yields of highly purified anti-PBO-antibodies were obtained.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0584
    Keywords: Chronisch-lymphatische LeukÄmie ; Enzyme des Purin-Interconversionssystems ; Purin-Nucleosid-Phosphorylase ; Adenosin-Deaminase ; Chronic lymphatic leukemia ; Purine interconversion system enzyme activities ; Purine nucleoside phosphorylase ; Adenosine deaminase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Activities of adenosine deaminase (ADA), adenosine kinase (AK), adenine phosphoribosyltransferase (APRT), hypoxanthine guanine phosphoribosyltransferase (HGPRT), and purine nucleoside phosphorylase (PNP), all enzymes of the purine interconversion system, were determined in lymphocytes of 25 patients with chronic lymphatic leukemia (CLL) and in 23 controls. A statistically significant decrease of PNP activities and a reduction of ADA activities at borderline levels were found in the patients, whereas for the other enzymes assayed no deviation from normal values was observed.
    Notes: Zusammenfassung Bei 25 Patienten mit chronisch-lymphatischer LeukÄmie (CLL) und 23 Kontrollpersonen wurden die AktivitÄten der Purin-Interconversionsenzyme Adenosin Deaminase (ADA), Adenosin Kinase (AK), AdeninPhosphoribosyltransferase (APRT), Hypoxanthin-Guanin-Phosphoribosyl-transferase (HGPRT) und Purin-Nucleosid-Phosphorylase (PNP) bestimmt. Dabei konnte bei den Patienten mit CLL eine statistisch signifikant verminderte PNP-AktivitÄt sowie eine grenzwertig reduzierte ADA-AktivitÄt festgestellt werden, wÄhrend die AktivitÄten der anderen untersuchten Purin-Interconversionsenzyme im Normalbereich lagen.
    Type of Medium: Electronic Resource
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