ZIB

Digitale Medien

A PROSPECTIVE, CONTROLLED TRIAL OF SIX FORMS OF HORMONE REPLACEMENT THERAPY GIVEN TO POSTMENOPAUSAL WOMEN (1979)

Lind, T. ; Cameron, E. C. ; Hunter, W. M. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

BJOG 86 (1979), S. 0

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1471-0528

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: This study was undertaken to investigate the effect of various forms of hormone replacement therapy (HRT) upon postmenopausal women while controlling as many variables as possible. It was felt that the age, duration of amenorrhoea and the general health of the patients should be as comparable as possible and that each patient should provide her own pretherapy and posttherapy control data. In addition, it was felt that any placebo effect should be investigated and the patients were therefore randomly allocated to placebo tablets or one of six available forms of HRT. The age/sex registers of two large general practices were scrutinized and all women between 49 and 54 years of age were asked to cooperate; for a variety of reasons only 56 women were suitable and willing to take part in the project, yielding 8 women for each of the seven possible therapy groups. Blood samples were taken at 7-day intervals three times before therapy was given and the mean of the three values was used as the control value. The women returned on day 21 of each subsequent therapy cycle for six consecutive months and finally three months after discontinuing therapy. From the data the following broad conclusions can be drawn: (i) some women have classic symptoms of hot flushes and sweating despite high endogenous oestrogen concentrations; (ii) vaginal cytology is a relatively poor indicator of endogenous oestrogen status; (iii) while follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations are reduced on HRT neither is decreased to anywhere near premenopausal values while prolactin is unaffected; (iv) plasma cholesterol levels are reduced on HRT, the pulse rate is slower and both systolic and diastolic blood pressure are reduced to a small but significant extent; (v) there is no adverse effect upon blood clotting; and (vi) most women experience significant or complete relief of symptoms on all forms of HRT as do some women taking a placebo. The combined preparations containing an oestrogen and progestogen produced vaginal bleeding in only 80 per cent of the women. Thus protection by regular endometrical shedding may not be afforded to all women. As vaginal bleeding is unacceptable to most women if they can achieve the same symptomatic relief without inducing menstruation, it is suggested that women have a low dose oestrogen preparation prescribed cyclically for 6 to 12 months. If therapy is to be maintained for a longer time, uterine curretage should be undertaken at regular intervals to exclude the possibility of endometrial carcinoma developing.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-0528.1979.tb16232.x

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

IQ Statistics (1975)

MORAN, P. A. P.

[s.l.] : Nature Publishing Group

Nature 254 (1975), S. 11-11

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] SIR,-A recent editorial (September 27) has drawn attention to the unfortunate social consequences of the recent controversy about the possibility of genetic contributions to the observed differences between the average IQs of different races. It does not seem' to have been noticed that many of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/254011c0

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

On the evolution of families of periodic orbits approaching a small primary (1975)

Markellos, V. ; Moran, P. E. ; Black, W.

Springer

Astrophysics and space science 33 (1975), S. L29

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1572-946X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Physik

Notizen: Abstract A network of families of periodic orbits is obtained approximately for the case μ=0.1 of the restricted problem using a direct grid search. Only such orbits of the third body are considered that cross the synodical line of the primaries ‘outside’ the smaller of the two, perpendicularly, and in the direction of rotation of the system.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00640118

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Another quasi-Poisson plane point process (1976)

Moran, P. A. P.

Springer

Probability theory and related fields 33 (1976), S. 269-272

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1432-2064

Quelle: Springer Online Journal Archives 1860-2000

Thema: Mathematik

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00534778

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Highly perturbed periodic oscillations around a small primary (1975)

Markellos, V. V. ; Moran, P. E. ; Black, W.

Springer

Astrophysics and space science 33 (1975), S. 385-419

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1572-946X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Physik

Notizen: Abstract A global picture of the families of simple periodic orbits in terms of their characteristics is given in the part of the plane (γ, ξ1) of representation near the singularity corresponding to the small primary, for the case of the restricted problem with a small value of the mass parameter μ. The value used for μ is smaller than the critical value of Routh. The picture is found to be qualitatively different from the one corresponding to μ larger than the critical value. By means of the stability parameters four new families, consisting of asymmetric periodic orbits, are shown to exist as bifurcations of families of symmetric periodic orbits.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00640107

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 5 | 5 Treffer