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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 379 (1978), S. 25-33 
    ISSN: 1432-2307
    Keywords: Electron microscopy ; Microfilaments ; Microtubules ; Nuclear pockets ; Smooth muscle tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Samples of gastric leiomyosarcomas from two male patients (69 years and 57 years of age) were studied by electron microscopy. The tumour cells contained abundant 50–90 å thick microfilaments and microtubules. Another cell type, regarded as immature leiomyosarcoma cell, contained numerous profiles of granular endoplasmic reticulum, free ribosomes and a well developed Golgi apparatus. There were intercellular junctions of zonula adherens-type between adjacent tumour cells. It was concluded that electron microscopy offers a valuable aid in the diagnosis of gastric neoplasms of smooth muscle origin.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 84 (1975), S. 189-192 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Fall eines primären Lymphosarkoms im Testis wurde licht- und elektronenmikroskopisch untersucht. Die Feinstruktur der Tumorzellen ist monoton. Das spärliche Cytoplasma enthält normale Zellorganellen. Freie Ribosomen sind zahlreich und der Golgi-Apparat ist gut entwickelt. Die Kerne sind groß und unregelmäßig, die Nukleolen prominent. Einige Kerne enthalten “nuclear pockets” mit Material, das der cytoplasmatischen Grundsubstanz ähnlich ist. Reste degenerierender Zelle werden ebenfalls gefunden.
    Notes: Summary A case of primary lymphosarcoma of testis was studied by light and electron microscopy. The fine structure of the lymphosarcoma cells was simple and monotonous. The cytoplasm was scanty and contained normal-looking organelles. Free ribosomes were abundant and the Golgi apparatus was well developed. The nuclei were large and irregular in shape with prominent nucleoli. “Nuclear pockets” enclosing material similar to the cytoplasmic ground substance were found infrequently. Remnants of disintegrating cells were also encountered.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 165 (1975), S. 163-168 
    ISSN: 1433-8580
    Keywords: Amylase secretion ; Exocrine pancreas ; Microtubules ; Vinca alkaloids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Inbred BALB/c mice were given vinblastine sulfate (VelbeR) and/or pilocarpine hydrochloride (20 mg/kg) intraperitoneally and amylase activity was determined in the pancreas homogenate. When vinblastine was given 5 hours before measuring the pancreatic amylase content it inhibited the pilocarpine stimulated (2 hours) pancreatic secretion in a dosis-dependent fashion at doses 4, 40 and 400 mg/kg. Vinblastine (200 mg/kg) also delayed amylase accumulation during 3 hours in mice given vinblastine 2 hours after pilocarpine stimualtion. The results support the hypothesis that faultless function and integrity of microtubules might be a prerequisite of pancreatic acinar cell secretionin vivo. Other effects of vinblastine, such as interference with amino acid metabolism, anticholinergic action, and cell injury must also be considered when interpreting the present findings form the point of view of the secretory mechanism of the pancreatic acinar cells.
    Type of Medium: Electronic Resource
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