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  • 1
    Electronic Resource
    Electronic Resource
    Subgrid-scale model for the temperature fluctuations in reacting hypersonic turbulent flows (1999)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 11 (1999), S. 2765-2771 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A direct numerical simulation (DNS) database is used to develop a model of subgrid-scale temperature fluctuations for use in large-eddy simulations of turbulent, reacting hypersonic flows. The proposed model uses a probability density representation of the temperature fluctuations. The DNS database reveals a physically consistent relation between the resolved-scale flow conditions that may be used to predict the standard deviation of the Gaussian probability density function (PDF). The model is calibrated and tested by comparison to simulations of decaying isotropic turbulence. The conditional single-variable PDF model is found to capture the fluctuations in temperature and product formation. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.870135
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of chemical reactions on decaying isotropic turbulence (1998)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 10 (1998), S. 1715-1724 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: There have been many studies of turbulent combustion flows, however the interaction between turbulent motion and the chemical reactions that occur in hypersonic flows has not been studied. In these flows, the rate of product formation depends almost exclusively on the temperature, and small temperature fluctuations may produce large changes in the rate of product formation. To study this process, we perform direct numerical simulations of reacting isotropic turbulence decay under conditions typical of a hypersonic turbulent boundary layer flow. We find that there is a positive feedback between the turbulence and exothermic reactions. That is, positive temperature fluctuations increase the reaction rate, thereby increasing the heat released by the reaction, which further increases the temperature. Simultaneously, the pressure increases causing localized expansions and compressions that feed the turbulent kinetic energy. The Reynolds stress budget shows that the feedback occurs through the pressure-strain term. We also find that the strength of the feedback depends on how much heat is released, the rate at which it is released, and the turbulent Mach number. The feedback process is negative for endothermic reactions, and temperature fluctuations are damped. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.869688
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  • 3
    Electronic Resource
    Electronic Resource
    Purification and Characterization of Guanine Nucleotide-Exchange Factor, eIF-2B, and p37 Calmodulin-Binding Protein from Calf Brain (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Eukaryotic initiation factor 2B, or guanine nucleotide-exchange factor, has been purified for the first time from the brain by a novel procedure that allows the purification of initiation factor 2 as well and uses a salt wash postmicrosomal supernatant as starting material. The procedure includes a three-part chromatographic step in heparin-Sepharose and in SP-5PW and diethylaminoethyl-5PW ion-exchange high-performance chromatographies. The purification of the factors was followed by measuring activity in the guanine nucleotide-exchange assay and the capacity of initiation factor 2 to form a ternary complex with the initiation form of methionyl-tRNA and GTP. The method yields guanine nucleotide-exchange factor (75%) and highly purified initiation factor 2 (〉95%), which are separated in the last step. The exchange factor from the brain is a multimeric protein with five subunits of molecular masses of 82, 65, 52, 42, and 30 kDa; it stimulates ternary complex formation in the presence of GDP, and this activity is inhibited by N-ethylmaleimide. A 37-kDa protein that copurifies with initiation factors is characterized in this study as a new calmodulin-binding protein (p37); it is highly phosphorylated by casein kinase activities and can comigrate with the α subunit of initiation factor 2 under standard sodium dodecyl sulfate electrophoresis conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65020754.x
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  • 4
    Electronic Resource
    Electronic Resource
    Increased Activity of Eukaryotic Initiation Factor 2B in PC12 Cells in Response to Differentiation by Nerve Growth Factor (1998)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 71 (1998), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Translational rates, and activities and levels of initiation factors 2 and 2B were assessed in rat pheochromocytoma cells upon nerve growth factor (NGF) treatment. Two or 5 days of exposure to NGF caused significant quantitative increases in protein synthesis rate that are deemed necessary for neuronal differentiation. Changes in initiation factor 2 activity, as measured by its capacity to form a ternary complex, occur parallel to the observed changes in protein synthesis. Nevertheless, neither the intracellular levels of the initiation factor 2 nor the degree of phosphorylation of its α subunit can justify this increased activity. Interestingly, initiation factor 2B activity increases parallel to the neurite outgrowth, being significantly higher after 5 days of exposure to NGF, and could be responsible for the elevated rate of protein synthesis. No significant changes in the levels of eukaryotic initiation factor 2B, as determined with two different antibodies against the γ and ε subunits of the factor, were observed, implying that the increased activity should be regulated by factors other than its cellular concentration. Our results support the hypothesis that initiation factor 2B may play a role in the biochemical events controlling the differentiative growth factor-induced signaling pathway in these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1998.71051905.x
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  • 5
    Electronic Resource
    Electronic Resource
    The Physical Properties of Skin in Cutis Laxa (1971)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 85 (1971), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1971.tb14094.x
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  • 6
    Electronic Resource
    Electronic Resource
    THE ROLE OF THE EPIDERMIS IN THE HISTOPATHOGENESIS OF LICHEN AMYLOIDOSUS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 85 (1971), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.— Biopsies from 10 patients with lichen amyloidosus were investigated histochemically with special reference to the epidermal changes. The number of dopa-positive melanocytes was markedly decreased in the epidermis overlying the amyloid deposits, indicating that melanocytes are also involved and probably destroyed by the disease process. No increase in lysosomal enzyme activity could be detected in epidermal cells undergoing degeneration or in the epidermis immediately above the amyloid deposits. Respiratory enzyme activity was moderately reduced in the epidermis overlying the amyloid deposits. These histochcmical findings confirm that the epidermis is likely to be involved in the histopathogenesis of lichen amyloidosus. It is suggested that, prior to the deposition of amyloid, a specific cellular tolerance may develop to the presence of necrotic epidermal cells in the region of the dermo-epidermal junction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1971.tb14077.x
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  • 7
    Electronic Resource
    Electronic Resource
    (5) Widespread atypical lichen amyloidosus, primary biliary cirrhosis and scleroderma (1974)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 91 (1974), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1974.tb12508.x
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  • 8
    Electronic Resource
    Electronic Resource
    Macular amyloidosis simulating naevoid hyperpigmentation (1974)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 90 (1974), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 17-year-old female is described who presented with an unusual form of macular amyloidosis which closely simulated naevoid hyperpigmentation. Electron microscopy was necessary to provide specific identification of the sparse deposits of amyloid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1974.tb06435.x
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  • 9
    Electronic Resource
    Electronic Resource
    THE PATHOGENESIS OF LICHEN PLANUS (1972)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 86 (1972), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1972.tb02233.x
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  • 10
    Electronic Resource
    Electronic Resource
    PERIORAL DERMATITIS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 84 (1971), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1971.tb14214.x
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