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  • 1970-1974  (1)
  • 1960-1964  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    THE PRIMARY BIOCHEMICAL LESION LEADING TO THE DELAYED NEUROTOXIC EFFECTS OF SOME ORGANOPHOSPHORUS ESTERS (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —In contrast with neurotoxic organophosphates of the type (RO)2P.O.X several phosphinates (R2P.O.X) cause prolonged inhibition of ‘neurotoxic esterase’in vivo but do not cause delayed neurotoxicity even after repeated administration. Prior administration of these phosphinates protected hens against the neurotoxic effects of several organophosphates: this protection lasted until about 70 per cent of the enzyme site again became available for phosphorylation. In this respect phosphinates behave like carbamate and sulphonyl fluoride inhibitors of ‘neurotoxic esterase'. It is proposed that the development of delayed neurotoxicity requires phosphorylation of the esterase followed by hydrolysis of one remaining phosphoryl ester bond to produce a charged monosubstituted phosphoric acid group attached to the protein. Generation of such a group could not occur after inhibition by the protective phosphinates, carbamates or sulphonates. It is proposed that the charged group is responsible for the metabolic disturbance leading to degeneration of long axons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04404.x
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of Sub-cellular Particles prior to Assay of the Enzymatic Marker, Succinic Dehydrogenase (1962)
    [s.l.] : Nature Publishing Group
    Nature 196 (1962), S. 1210-1211 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] 100 per cent recovery of activity is necessary in meaningful distribution studies and is usually, though not necessarily, achieved most easily when each fraction sample is made to show the maximum activity of which it is capable with the chosen assay system. For fractions obtained from brain ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1961210a0
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    Paper (German National Licenses)
    Fulltext
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