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  • 1
    Electronic Resource
    Electronic Resource
    Growth kinetics of mammalian embryos during the stage of differentiation (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 272 (1972), S. 169-181 
    Details
    ISSN: 1432-1912
    Keywords: Embryonic Growth ; DNA ; RNA ; Nuclei
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to get insight into the synthesis rates occuring in mammalian embryos during the phase of differentiation, wet and dry weight as well as DNA-, RNA-, and nitrogen content of the whole implantation site (day 7 to 10 of gestation) and of the embryos (day 11 to 14) have been determined. Growth of the whole implantation site (day 7 to 10) proceeds almost linearly: Within a 24-h period the weight increases about 2-fold. The growth of the embryos, however, is found to be different in each 24-h period between day 8 and 14. All synthesis processes proceed at an extremely rapid rate between day 9 and 12 of gestation. The weight of embryos shows a 6-fold rise between day 11 and 12, the increase being even more pronounced on the preceding days. Growth and increase in cell mass are essentially due to cell division, since DNA content and weight change in a parallel way. Data on the nitrogen content per embryo show that the protein synthesis keeps pace with the rapid cell division. Using pure nuclear fractions isolated from 11- to 14-day-old embryos the average distribution of RNA within the cells can be estimated. The increase in the number of cells within a 24-h period is calculated from the average DNA content per embryo and the average DNA content per nucleus measured in isolated nuclei. The DNA content per nucleus of 12- to 14-day-old rat embryos is found to be almost twice (12±0.5 pg) that of diploid nuclei (6.7–7.2 pg). This inducates that a high percentage of the cells are in the late S-phase or in the G2-phase. The growth rate of the embryos between day 8 and 14 of gestation is calculated from the 24-h rate of increase in cell number which is obtained either biochemically or in the earlier stage of embryonic development with morphological studies. Some peculiarities of the duration of the cell cycle of the rapidly growing tissue are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508767
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of cyclophosphamide pretreatment of pregnant animals on the activity of nuclear DNA-dependent RNA-polymerases in different parts of rat embryos (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 71-88 
    Details
    ISSN: 1432-1912
    Keywords: Cyclophosphamide ; Embryonic Development ; DNA-Dependent RNA Polymerases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On day 13+0 h of gestation rats received 10 mg/kg cyclophosphamide i.p. 3, 9, and 24 h after administration of the drug the activities of the DNA-dependent RNA polymerase reactions were measured in the whole embryo and in parts of it (head, upper and lower extremities and trunk). The activities of these enzymes were correlated with the increase in the RNA content of these tissues. A relationship was established light and electron microscopically between the biochemical results and the specific alterations which occur in different structures of the embryonic tissue. The results of these investigations show that: 1. cyclophosphamide leads-in dependency on the time-to a decrease or increase in the Mn++- and/or Mg++-stimulated RNA polymerase reactions in isolated cell nuclei of individual parts of the embryo 2. alterations in the enzyme activities of individual parts of the embryo are not detected when the enzyme activity of the whole embryo is measured at the early day 13 of gestation 3. towards the end of gestation malformations can be demonstrated only in those parts of the embryo, where 24 h after the administration of cyclophosphamide the enzyme pattern shows a highly significant deviation from that of the controls and where cell necroses can be demonstrated light and electron microscopically. Moreover, in the nucleolus of the neuroepithelium segregation of its components takes place which correlates well with the decreased r-RNA polymerase activity. In this paper a disturbance of the transcription mechanisms is discussed as being the primary mode of action of cyclophosphamide in cell metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498786
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of respiratory acidosis on heart and circulation in cats, pigs, dogs and rabbits (1972)
    Springer
    Research in experimental medicine 158 (1972), S. 308-320 
    Details
    ISSN: 1433-8580
    Keywords: Respiratory Acidosis ; Cardiovascular Effects ; Sympathomimetic Amines ; Species Differences ; Respiratorische Acidose ; Kreislauf ; Sympathomimetica ; Speciesunterschiede
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Katzen, Hunden, Kaninchen und Hausschweinen wurden in Pentobarbitalnarkose nach Muskelrelaxation mit Alloferin® bei geschlossenem Thorax die Auswirkungen einer akuten respiratorischen Acidose auf den Kreislauf sowie dessen Reaktion auf Pharmaka untersucht. 1. BeiKatzen undSchweinen steigen in respiratorischer Acidose Herzfrequenz, dp/dtmax und Blutdruck an; beiKaninchen bleiben dp/dtmax und Blutdruck nahezu unverändert. BeiHunden hingegen sinken Schlagfrequenz, dp/dtmax und Blutdruck in Acidose ab. Untersuchungen an Katzen, die mit Reserpin vorbehandelt waren, zeigten, daß eine respiratorische Acidose einen negativ inotropen und blutdrucksenkenden Eigeneffekt besitzt. Nach Vorbehandlung mit Phenoxybenzamin verursacht eine respiratorische Acidose bei Katzen einen Blutdruckabfall sowie einen Anstieg von dp/dtmax. Nach Vorbehandlung mit Pindolol verursacht eine Acidose eine Abnahme von Frequenz und dp/dtmax, während der Blutdruck konstant bleibt. Am unvorbehandelten Tier wird der negativ inotrope Effekt einer Acidose offenbar durch eine Stimulierung des sympathischen Nervensystems überdeckt, die bei Katzen und Schweinen am ausgeprägtesten ist. 2. DieWirkung sympathomimetischer Amine auf Herz und Kreislauf ist bei allen 4 untersuchten Tierarten in Acidose abgeschwächt, wobei die Abschwächung bei den Tieren mit der stärksten sympathischen Stimulation am ausgeprägtesten ist. 3. Biochemische Untersuchungen an Hunden und Katzen ergaben, daß in Acidose K+, Mg2+, anorganisches Phosphat und Glucose im Serum ansteigen, während der Magnesiumgehalt des Herzmuskels abnimmt.
    Notes: Summary In closed chest cats, dogs, rabbits and pigs, anaesthetized with pentobarbital and relaxed with diallylnortoxiferinium dichloride the effects of a respiratory acidosis on heart and circulation as well as their reaction to sympathomimetic amines were studied. 1. Incats andpigs a respiratory acidosis causes a rise of frequency, dp/dtmax of the left ventricle and systolic blood-pressure. Inrabbits an acidosis causes no significant alteration of blood-pressure and dp/dtmax. Indogs frequency, dp/dtmax and blood-pressure decline in acidosis. In cats pretreated withreserpine a respiratory acidosis causes a negative inotropic effect and a declining of blood-pressure. After pretreating cats withphenoxybenzamine in acidosis there results a decrease of blood-pressure, but a rise of dp/dtmax and frequency; after pretreating withpindolol in acidosis dp/dtmax and frequency decline, but blood-pressure remains unaltered. 2. The effectiveness of sympathomimetic amines on heart and circulation is diminished in acidosis. This diminution is most significant in those animals (cat, pig) with the most augmented sympathetic tonus in acidosis, but experiments performed with reserpinized cats indicated that the augmented sympathetic tonus can not be the only cause for the diminished efficiency of adrenergic stimulant amines in acidosis. 3. Biochemical studies performed in acidosis showed a rise of K+, Mg2+, inorganic phosphate and glucose in serum and a decrease of Mg2+ in the heart muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852214
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  • 4
    Electronic Resource
    Electronic Resource
    Der Einfluß des Blut-pH auf die Toxicität herzwirksamer Glykoside (1972)
    Springer
    Research in experimental medicine 159 (1972), S. 65-74 
    Details
    ISSN: 1433-8580
    Keywords: Cardioactive glycosides ; Respiratory acidosis ; Alcalosis ; β-sympatholytic drugs ; Herzwirksame Glykoside ; Respiratorische Acidose ; Alkalose ; β-Sympathicolytica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An narkotisierten Katzen wurde der Einfluß des Blut-pH auf die Toxicität herzwirksamer Glykoside untersucht. An isolierten Vorhofpräparaten wurden in Ergänzung hierzu Versuche mit Änderung des pH der Tyrodelösung durchgeführt. 1. An Katzen wird durch eine respiratorische Acidose (pH 7,0) die Toxicität des Digitoxins, Digoxins und k-Strophanthins signifikant erhöht; dabei ist die Toxicität des Digitoxins stärker erhöht als die des Digoxins und k-Strophanthins. 2. Vorbehandlung mit Reserpin oder Practolol vermindert die Toxicität des Digitoxins in Acidose wesentlich stärker als bei normalem pH. 3. Eine durch Tris-Infusion erzeugte Alkalose von pH 7,6 bewirkt keine Änderung, eine durch Infusion von NaHCO3 erzeugte Alkalose von pH 7,6 verursacht eine geringfügige Steigerung der Digitoxintoxicität. 4. Am isolierten Vorhofpräparat des Meerschweinchens ist die Toxicität des Digitoxins, Digoxins und k-Strophanthins bei pH-Werten der Tyrodelösung von 7,0 und 7,8 nicht signifikant verschieden.
    Notes: Summary In anaesthetized cats the influence of blood-pH on the toxicity of cardiac glycosides was studied. In isolated guinea pigs atrias further experiments were performed by changing the pH of the tyrode solution. 1. In cats with respiratory acidosis (pH 7.0) the toxicity of digitoxin, digoxin and k-strophanthin is enhanced — thereby the toxicity of digitoxin is more enhanced than that of digoxin and k-strophanthin. 2. Pretreatment with reserpine or practolol diminishes the toxicity of digitoxin in acidosis more than at normal blood-pH. 3. An alcalosis of pH 7.6, produced by the infusion of tris causes no change, an alcalosis of pH 7.6 produced by the infusion of NaHCO3 causes a small increase of the toxicity of digitoxin. 4. In the isolated guinea pigs atria the toxicity of digitoxin, digoxin and kstrophanthin is not different at pH 7.0 and 7.8 of the tyrode solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852143
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  • 5
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    Unknown
    Scholastische Aesthetik und höfische Dichtung (1953)
    Groningen, Netherlands : Periodicals Archive Online (PAO)
    Neophilologus. 37:4 (1953:oct. 1) 202 
    Details
    ISSN: 0028-2677
    Topics: Linguistics and Literary Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5262-1953-037-04-000002
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  • 6
    Electronic Resource
    Electronic Resource
    Activity of some enzymes of nucleic acid metabolism in developing rat liver (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 385-393 
    Details
    ISSN: 1432-1912
    Keywords: Liver Development ; Thymidine Kinase ; DNA Polymerase ; RNA Polymerases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The increase in DNA, RNA, and nitrogen as well as the activity of some enzymes involved in nucleic acid metabolism were measured during liver development. During the perinatal period (day 18 of gestation until birth) high activities of thymidine kinase and DNA polymerase were found which decline in the early suckling period, whereas the activities of the DNA-dependent RNA polymerases show a slow continuous increase. During the juvenile period (starting about 4 weeks after birth) the values of all enzymes studied approximate to those measured in liver tissue of adult animals. The correlation of these enzymes with the growth kinetics of liver tissue is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501275
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  • 7
    Electronic Resource
    Electronic Resource
    Das Verhalten deutscher Kartoffelsorten gegenüber verschiedenen Stämmen des X-Virus im Pfropfversuch (1953)
    Springer
    Theoretical and applied genetics 23 (1953), S. 72-86 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00712181
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  • 8
    Electronic Resource
    Electronic Resource
    DerSolanum demissum-Bastard „A 6” als Testpflanze verschiedener Mosaikviren (1953)
    Springer
    Theoretical and applied genetics 23 (1953), S. 173-176 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Zusammenfassung Aus einer großen Zahl von F1-Bastarden der KreuzungSolanum demissum mit der Kultursorte Aquila wurde in mehrjähriger Prüfung ein mit A 6 bezeichneter Stamm als geeignete Testpflanze zum Nachweis von Mosaikviren der Kartoffel ermittelt. Es werden die Versuchsbedingungen mitgeteilt, die bei der Anwendung des Testes eingehalten werden müssen. Die Anwendbarkeit erstreckt sich auf die verschiedenen Typen und Stämme der Kartoffelviren A, X, Y, sowie auf das Rattle-Virus (Stengelbont), das Bukett-ring-spot-Virus und das Aucuba (F/G)-Virus. Außerdem ergab sich, daß der genannte Bastard auf die verschiedenen Stämme des Tabakmosaik-virus mit ganz eigentümlichen, offenbar spezifischen Symptomen reagiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717512
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  • 9
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopische Untersuchung des Kartoffel-X-Virus (1951)
    Springer
    Naturwissenschaften 38 (1951), S. 355-355 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00594670
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  • 10
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopische Untersuchung des Tabakmosaikvirus (1951)
    Springer
    Naturwissenschaften 38 (1951), S. 431-431 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630739
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