ISSN:
1432-1912
Keywords:
Oxyfedrine
;
Biliary Excretion
;
Norephedrine
;
Catecholamine Release
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Pharmacokinetic studies with orally administered 14C-oxyfedrine were carried out in rats and also in men. 1. In the rat tissue concentrations of oxyfedrine (determined by UV absorption) and 14C-radioactivity reached a maximum within 15 min. Recovery of oxyfedrine equaled that of 14C-activity (14C-oxyfedrine + 14C-labelled metabolites) in the heart and lung tissues, but differed somewhat in the liver and kidney extracts. 2. In experiments with bile fistula rats, 3 metabolites were recovered in the bile: a main metabolite, as an unlabeled, ninhydrin-positive substance (M1) besides two 14C-labeled minor metabolites*. 3. Approximately 40 to 50% of the oxyfedrine applied appeared in the urine as metabolites of oxyfedrine, mainly norephedrine, in rats and men. 4. The pharmacological significance of these findings is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500060
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