ISSN:
1432-0428
Keywords:
Blood glucose
;
plasma insulin
;
prediabetes
;
diabetes
;
prospective survey
;
weight change
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Blood glucose and plasma insulin concentrations have been measured in the fasting state and 15, 30, 45, 60, 90 and 120 min after 50 g glucose administered orally to subjects tested in a similar manner 5 years previously. — As a result of the previous test the subjects had been divided into three groups: Group I — normal glucose tolerance, no glucosuria; Group II — normal glucose tolerance and glucosuria; Group III — normal fasting blood sugar concentration, but a failure of the blood sugar to return to the fasting level up to 120 min after glucose. — None of the subjects previously classified as normal (Group I), but three (all previously obese) of Group II and five (three previously obese) of Group III had become diabetic. — There was an increasing tendency to loss of weight the worse the glucose tolerance. For all subjects the weight change and change in the 120 min blood glucose concentration, gave a correlation coefficient of −0.47 (p〈0.01). Group III subjects previously of normal weight gained weight (p〈0.02). — It was concluded that obese subjects with defective initial rises in plasma insulin concentration following oral glucose were those most likely to develop diabetes. Some obese subjects with normal glucose tolerance, glucosuria and apparently normal early insulin rise were also prediabetic. — The results suggested that in the former, but not the latter subjects, continued deterioration of the early insulin response was a factor in the emergence of diabetes, but due to the small numbers of subjects no definite conclusion could be reached on this point.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00423041
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