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  • 1
    Electronic Resource
    Electronic Resource
    Drug-induced changes in blood flow in the acutely ischaemic canine myocardium; relationship to subendocardial driving pressure (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 1 (1974), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY 1. The effects of various drugs have been studied on blood flow and oxygen handling (availability, extraction and consumption) in both normal and acutely ischaemic regions of the canine myocardium. Ischaemia was produced by the acute ligation of the anterior descending branch of the left coronary artery.2. Lidoflazine, like other coronary vasodilator drugs, increases blood flow in the normal myocardium, but does not increase flow through the ischaemic region. Drugs of this type may, in addition, open up ‘shunt’ vessels within the ischaemic region.3. Of three cardiac stimulants studied, only oxyfedrine consistently increases blood flow through the ischaemic region; isoprenaline and glucagon do not.4. Noradrenaline causes marked increases in flow through the ischaemic region: its effect is associated with an increase in coronary pressure in the artery distal to the ligature.5. Evidence is put forward that the critical factor determining flow through ischaemic regions of the myocardium is the transventricular driving pressure. When the effects of various drugs on flow and driving pressure are analysed and compared, the only drugs that increase flow in an ischaemic region are those that increase the pressure gradient across the wall of the left ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1974.tb00531.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of dilazep on blood flow and oxygen handling in the early stages of canine myocardial infarction (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 427-436 
    Details
    ISSN: 1432-1912
    Keywords: Dilazep ; Adenosine Potentiation ; Myocardial Blood Flow ; Myocardial Infarction ; Coronary Stealing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of dilazep, a drug which potentiates the actions of adenosine, were examined in a canine preparation that enabled simultaneous measurements to be made of blood flow both in ischaemic areas, and in essentially normal areas, of the canine myocardium. In doses which caused marked and sustained increases in blood flow to the normal myocardium, dilazep did not change either blood flow in the developing infarct or the trans-ventricular perfusion pressure (diastolic peripheral coronary pressure minus left ventricular end-diastolic pressure). Despite the lack of effect on infarct blood flow, the oxygen tension of the blood draining the infarcting area was markedly elevated. It is concluded that dilazep may open up blood vessels in an acutely ischaemic area which do not take part in tissue exchange, and may therefore decrease the efficiency of the myocardial circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499437
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Reduction in ventricular arrhythmias following acute coronary artery ligation in the dog after the administration of creatine phosphate (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 437-441 
    Details
    ISSN: 1432-1912
    Keywords: Creatine Phosphate ; Acute Myocardial Infarction ; Arrhythmias ; Antiarrhythmic Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The infusion of creatine phosphate into the left ventricle of dogs markedly reduced the number of ventricular ectopic beats which normally result from acute coronary ligation. This dose of creatine phosphate (100 mg/kg) had no significant effect on resting haemodynamics or on myocardial metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499438
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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