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  • 1
    Electronic Resource
    Electronic Resource
    The effects of ethanol and lead, alone and in combination, on the severity of arrhythmias induced by coronary artery occlusion, and by noradrenaline, in anaesthetised rats (1986)
    Springer
    Archives of toxicology 59 (1986), S. 56-60 
    Details
    ISSN: 1432-0738
    Keywords: Ethanol ; Lead ; Ischaemia ; Induced arrhythmias ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate whether chronic (3 or 10 months) administration, via the dinking water, of lead (25 ppm) and/or ethanol (25% v/v) altered the susceptibility of the heart to arrhythmias induced either by coronary artery occlusion or noradrenaline infusion in pentobarbitone-anaesthetised male Sprague-Dawley rats. The cardiac effects of acute intravenous infusions of ethanol (17, 33 and 66 mg kg−1 min−1) were also measured. Chronic exposure to ethanol and/or lead in the drinking water had no marked effect on the severity of arrhythmias occurring within the initial 30 min of coronary artery occlusion. In control rats and in those administered ethanol and/or lead for 10 months, noradrenaline (16 μg kg−1 min−1 given IV 1 h post-occlusion for a 15-min period) induced a similar number of ectopic beats during the infusion period, although these arrhythmias persisted beyond the infusion period in treated animals only. There was a significant accummulation of lead in the bone but not in the blood of lead-treated rats. Blood ethanol concentrations varied considerably between animals, ranging from 0 to 319 mg%. Ethanol (66 mg kg−1 min−1) given acutely and yielding a blood concentration of 174 mg % had a slight antiarrhythmic effect in this model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263959
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  • 2
    Electronic Resource
    Electronic Resource
    THE HAEMODYNAMIC EFFECTS OF QUAZODINE, A CARDIAC STIMULANT, IN EXPERIMENTAL E. COLI ENDOTOXIN SHOCK IN THE CAT (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 1 (1974), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY 1. Intravenous injections of quazodine (6,7-dimethoxy-4-ethylquinazoline, 0–5 mg/kg per min) in pentobarbitone-anaesthetized cats increased heart rate, the maximum rate of pressure development in the left ventricle (LV dP/dt max.), cardiac output and myocardial blood flow, and decreased systemic arterial blood pressure. The effects of this cardiac stimulant were examined 1, 2, and 3 h after the intravenous administration of 2 mg/kg of E. coli endotoxin.2. During the endotoxin shock phase (〉 1 h after endotoxin) the most pronounced effects were decreases in systemic blood pressure and cardiac output and a severe metabolic acidosis.3. Quazodine failed to increase cardiac output during endotoxin shock and the effects on the heart rate and LV dp/dt max. were much reduced. In contrast, quazodine-induced vasodilatation was much more marked.4. It is concluded that there is profound myocardial depression in severe endotoxin shock in the cat and that this cannot be significantly modified by quazodine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1974.tb00524.x
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  • 3
    Electronic Resource
    Electronic Resource
    Drug-induced changes in blood flow in the acutely ischaemic canine myocardium; relationship to subendocardial driving pressure (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 1 (1974), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY 1. The effects of various drugs have been studied on blood flow and oxygen handling (availability, extraction and consumption) in both normal and acutely ischaemic regions of the canine myocardium. Ischaemia was produced by the acute ligation of the anterior descending branch of the left coronary artery.2. Lidoflazine, like other coronary vasodilator drugs, increases blood flow in the normal myocardium, but does not increase flow through the ischaemic region. Drugs of this type may, in addition, open up ‘shunt’ vessels within the ischaemic region.3. Of three cardiac stimulants studied, only oxyfedrine consistently increases blood flow through the ischaemic region; isoprenaline and glucagon do not.4. Noradrenaline causes marked increases in flow through the ischaemic region: its effect is associated with an increase in coronary pressure in the artery distal to the ligature.5. Evidence is put forward that the critical factor determining flow through ischaemic regions of the myocardium is the transventricular driving pressure. When the effects of various drugs on flow and driving pressure are analysed and compared, the only drugs that increase flow in an ischaemic region are those that increase the pressure gradient across the wall of the left ventricle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1974.tb00531.x
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of bradykinin on blood flow and heat production in the myocardium (1963)
    Springer
    Cellular and molecular life sciences 19 (1963), S. 161-162 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé En utilisant comme méthode la calorimétrie interne, nous avons montré que la bradykinine synthétique abaisse la résistance vasculaire dans le myocarde du lapin, du chat et du singe, même à doses aussi réduites que 0,05 µg/kg. Des doses plus fortes (5 µg/kg) augmentent aussi l'activité métabolique du myocarde.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171613
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  • 5
    Electronic Resource
    Electronic Resource
    Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias (1981)
    [s.l.] : Nature Publishing Group
    Nature 291 (1981), S. 323-324 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The studies were performed in greyhounds (21-34 kg) anaesthetized with chloralose (80 mg per kg, intravenously) following induction with sodium thiopentone (25 mg per kg, intravenously). The animals were respired with oxygen using a positive pressure ventilation pump and catheters were placed in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/291323a0
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of dilazep on blood flow and oxygen handling in the early stages of canine myocardial infarction (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 427-436 
    Details
    ISSN: 1432-1912
    Keywords: Dilazep ; Adenosine Potentiation ; Myocardial Blood Flow ; Myocardial Infarction ; Coronary Stealing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of dilazep, a drug which potentiates the actions of adenosine, were examined in a canine preparation that enabled simultaneous measurements to be made of blood flow both in ischaemic areas, and in essentially normal areas, of the canine myocardium. In doses which caused marked and sustained increases in blood flow to the normal myocardium, dilazep did not change either blood flow in the developing infarct or the trans-ventricular perfusion pressure (diastolic peripheral coronary pressure minus left ventricular end-diastolic pressure). Despite the lack of effect on infarct blood flow, the oxygen tension of the blood draining the infarcting area was markedly elevated. It is concluded that dilazep may open up blood vessels in an acutely ischaemic area which do not take part in tissue exchange, and may therefore decrease the efficiency of the myocardial circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499437
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  • 7
    Electronic Resource
    Electronic Resource
    Reduction in ventricular arrhythmias following acute coronary artery ligation in the dog after the administration of creatine phosphate (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 281 (1974), S. 437-441 
    Details
    ISSN: 1432-1912
    Keywords: Creatine Phosphate ; Acute Myocardial Infarction ; Arrhythmias ; Antiarrhythmic Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The infusion of creatine phosphate into the left ventricle of dogs markedly reduced the number of ventricular ectopic beats which normally result from acute coronary ligation. This dose of creatine phosphate (100 mg/kg) had no significant effect on resting haemodynamics or on myocardial metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499438
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  • 8
    Electronic Resource
    Electronic Resource
    The effects of distension of the small intestine on myocardial blood flow in anaesthetised cats: possible relevance to coronary vasospasm (1977)
    Springer
    Basic research in cardiology 72 (1977), S. 437-443 
    Details
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die regionale Durchblutung des linken Ventrikels, welche mit geheizten Thermosonden gemessen wurde, nahm nach Darmdehnung meistens ab, während der arterielle Blutdruck zunahm. Arrhythmien wurden nicht beobachtet. Wenn der Effekt der Blutdruckerhöhung auf die Koronardurchblutung durch Anwendung partialer Korrelationskoeffizienten ausgeschaltet wurde, dann wurde eine umgekehrte Relation zwischen Myokarddurchblutung und Intestinaldruck gefunden, welches als eine koronare Vasokonstriktion gedeutet wurde. Es wird gefolgert, daß die Dehnung von Hohlorganen zu einem viscero-kardialen Reflex führe kann. Der resultierende Koronarspasmus könnte eine Ursache des Schmerzes bei Angina-pectoris-Patienten sien.
    Notes: Summary The haemodynamic effects of distending the small intestine (with a balloon in the lumen) were examined in cats anaesthetised with chloralose. Particular attention was paid to blood flow changes in localised areas of the left ventricular wall (as assessed using the heated thermocouple technique). Intestinal distension led to an increase in systemic blood pressure but usually to a reduction in myocardial blood flow; no cardiac dysrhythmias were observed. When the effect of increased systemic (perfusion) pressure on blood flow was eliminated (using partial correlation coefficients) flow then bore a negative relationship to intestinal pressure, probably indicating constriction of the myocardial blood vessles. This may indicate that distension of hollow organs can lead to a visceral-cardiac reflex. The resulting coronary vasospasm might be one cause of pain in certain patients with angina pectoris.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01910407
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  • 9
    Electronic Resource
    Electronic Resource
    Prostacyclin-induced changes in coronary blood flow and oxygen handling in the normal and acutely ischaemic canine myocardium (1981)
    Springer
    Basic research in cardiology 76 (1981), S. 457-462 
    Details
    ISSN: 1435-1803
    Keywords: prostacyclin ; coronary flow ; ischaemic myocardium ; oxygen utilization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01908342
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  • 10
    Electronic Resource
    Electronic Resource
    The evidence for α-adrenoceptors in the coronary circulation and their possible relevance to the physiological regulation of myocardial blood flow (1981)
    Springer
    Basic research in cardiology 76 (1981), S. 485-493 
    Details
    ISSN: 1435-1803
    Keywords: α-adrenoceptors ; coronary artery spasm ; coronary vasoconstriction ; sympathetic control of coronary circulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01908348
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