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  • 1
    Electronic Resource
    Electronic Resource
    Die Metabolisierung von p-Aminohippurat in Nieren von normalen Ratten und Ratten mit experimentellem Goldblatt-Hochdruck (1972)
    Springer
    Pflügers Archiv 333 (1972), S. 156-165 
    Details
    ISSN: 1432-2013
    Keywords: Kidney ; Goldblatt-Hypertension ; PAH-clearance ; PAH-Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary PAH-clearance studies were carried out separately on each kidney of both normal rats and rats with experimental Goldblatt-Hypertension. The rat and especially the rat kidney metabolizes a certain proportion of PAH-molecules 1. by splitting off the glycine-group forming p-aminobenzoate (PAB); 2. both PAH and PAB undergo partial N-acetylation. N-acetylated metabolites cannot be detected by the conventional analysis of PAH. Resorption of benzoates in the kidney results in a relatively high benzoate concentration in the renal vein. The complications created by these facts are discussed in relation to RPF-estimation using PAH. A correct determination of RPF by PAH is possible only if the analysis is carried out after an acid hydrolysis to make the detection of N-acetylated metabolites possible and if renal venous blood samples can be collected to correct for the reabsorbed benzoates. The clamped kidney of rats with Goldblatt-Hypertension is able to split glycine off from PAH but its capacity to N-acetylate is reduced. As a result identical PAH-clearances are found in both kidneys of these animals although their true RPF differ significantly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586914
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of dietary sodium on the renal enzyme-pattern of the rat (1973)
    Springer
    Pflügers Archiv 339 (1973), S. 339-348 
    Details
    ISSN: 1432-2013
    Keywords: Dietary Sodium ; Renal Enzyme Pattern
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between dietary sodium and the activity of representative renal enzymes of the three main metabolic pathways-oxydative breakdown, glycolysis and pentose-monophosphate-shunt-was studied in the rat kidney. Enzyme assays were carried out on total tissue homogenates and isolated mitochondria of the cortex and medulla as well as on isolated glomerula of rats maintained on low or high sodium diet for 14–17 days. While there was no difference in the weight-gain between rats maintained on low sodium food or normal laboratory chow, rats fed high sodium diet put on more weight and had larger kidneys than the other groups. The protein content of the total tissue homogenate followed the same pattern whereas equal amounts of mitochondrial or glomerular protein was found in all three groups. In all preparations both low, and to a greater extent, high dietary sodium increased the specific activity of the majority of enzymes assayed. No fall in the activity of any enzyme could be observed. A number of causal mechanisms are discussed. It is assumed that hyperaldosteronism in the low-sodium group and elevated vasopressin level in rats fed high-sodium diet are responsible for the identical results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00594168
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Nierenfunktion bei Ratten mit experimentellem DOCA-Hochdruck (1972)
    Springer
    Pflügers Archiv 332 (1972), S. 28-39 
    Details
    ISSN: 1432-2013
    Keywords: Kidney ; Experimental Hypertension ; DOCA ; Specific Reabsorption Capacity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats were made chronically hypertensive by unilateral nephrectomy, repeated injections of desoxycorticosterone-acetate and offering saline as drinking fluid (DOCA-rats). Unilaterally nephrectomized animals (Nephrex-rats) were used for control. Compensatory renal hypertrophy was greater in DOCA-rats than in Nephrex-rats. Diameter and length of the proximal convolute in the DOCA-group increased more than in Nephrex-rats. GFR per unit kidney weight in the DOCA-group remained unchanged as compared to untreated Wistar-rats but increased significantly in Nephrex-animals. the water and sodium load of each nephron had doubled in both groups. Nevertheless, there were no substantial changes in the fractional water and sodium reabsorption in the different segments of the nephron of DOCA-rats as compared to normal animals. In Nephrex-rats fractional sodium and water reabsorption were increased in the proximal tubule and diminished in the loop of Henle and in the distal tubule. In Nephrex-rats an indirect correlation was found between blood pressure and both water reabsorption and the transit time of Lissamine green in superficial loops of Henle but no such correlation could be found in the DOCA-group. Determination of the specific reabsorption capacity of the proximal tubules during free-flow or using the split-drop technique yielded identical values in all animals studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00603812
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Wasserhaushalt und Elektrolytstoffwechsel bei Ratten mit experimentellem und spontanem Hochdruck (1972)
    Springer
    Pflügers Archiv 332 (1972), S. 56-72 
    Details
    ISSN: 1432-2013
    Keywords: Water Electrolyte Balance ; Sodium ; Thirst ; Renal Artery Obstruction ; Renal Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats with spontaneous hypertension and rats with experimental hypertension elicited by constriction of one renal artery exhibited an enhanced sodium appetite similar to patients with essential hypertension. The hypertensive rats drank twice as much saline (0.9 g NaCl/100ml) as the controls, when given the choice between tap water and saline. In the rats with unilaterally constricted renal artery water intake was increased and plasma sodium concentration reduced. In these animals, body weight increased by 1.6%, plasma sodium returned to normal and polydipsia disappeared after the intake of saline. Polydipsia, hyponatremia and enhanced sodium appetite likewise disappeared after the removal of the contralateral kidney exposed to the high blood pressure. It is concluded from these results, that the natriuresis of the kidney exposed to the elevated blood pressure causes the enhanced sodium appetite and the polydipsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00603814
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    Paper (German National Licenses)
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