ISSN:
1432-0878
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary 15 liver biopsies from 13 patients suffering from non-hemolytic constitutional jaundice (6 cases of Gilbert's, 2 cases of Rotor's and 5 cases of Dubin-Johnson's disease) provided the basis of an ultrastructural study of pigment inclusions in liver cells following various techniques of preparation. The lipofuscin in Gilbert's syndrom and the pigment characteristic of Dubin-Johnson's syndrom contain two distinct components which are present in both types of inclusions but their proportions are different in these syndromes: a globular component, probably of lipidic nature, is the main constituent of the lipofuscin, a granulo-filamentous component the main constituent of the Dubin-Johnson's pigment. These two components react in both syndromes identically to various techniques of fixation, embedding and section-staining. In Rotor's syndrome other pigment inclusions are observed which are not detectable in ordinary histological preparations: they consist essentially of aggregates of dense, ferritin-like material. The presence, in the hepatocytes, of pigment inclusions which have some features in common in the 3 types of syndromes and other characteristics specific for each of them, confirms the close relation between these types of jaundice, but emphasizes also their differences; moreover, this ultrastructural study underlines the difficulty of an exact classification of these syndromes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00334273
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