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  • 1
    Electronic Resource
    Electronic Resource
    Excitability measurements at the central terminals of single mechano-receptor afferents during slow potential changes (1967)
    Springer
    Experimental brain research 3 (1967), S. 220-233 
    Details
    ISSN: 1432-1106
    Keywords: Mechanoreceptors ; Cutaneous Afferents ; Afterpotentials ; Primary Afferent Depolarization ; Spinal Cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mechanoreceptors of the hairy skin and the central pad of the cat's hind foot were activated using piezo-electric crystals as mechanical stimulators. Their afferent fibres were traced in the lumbar spinal cord by stimulating antidromically and by recording the collision of the antidromic and orthodromic action potentials. Low threshold mechanoreceptor units could be stimulated in isolation. It was possible, therefore, to follow the postspike excitability changes of their fibres in the spinal cord without interference from other spinal cord potentials. Primary afferent depolarization has been induced in cutaneous afferents by stimulating muscle and cutaneous nerves. It has been found that the a cutaneous fibres of mechanoreceptors were depolarized by volleys in a cutaneous fibres and to a lesser degree by volleys in Group I b, II and III muscle afferents but not by high threshold cutaneous afferents. The primary afferent depolarization of cutaneous fibres has been subjected to the action of an impulse propagating down that fibre to its central terminals. Excitability testing revealed that the amplitude and the time course of the primary afferent depolarization were only altered up to about 30 ms after the impulse indicating an active depolarization of the presynaptic terminals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235586
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  • 2
    Electronic Resource
    Electronic Resource
    Single unit responses and the total afferent outflow from the cat's foot pad upon mechanical stimulation (1968)
    Springer
    Experimental brain research 6 (1968), S. 100-115 
    Details
    ISSN: 1432-1106
    Keywords: Mechanoreceptors ; Pacinian corpuscles ; Cutaneous afferents ; Peripheral encoding ; Skin sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The properties of mechanosensitive units with large myelinated afferents were determined in the hairless skin of the central pad of the cat's hind foot, and the total afferent outflow from this region after short skin indentations and during constant force stimuli was measured in the plantar nerves. Basically three types of mechanosensitive units with afferent conduction velocities above 40 m/s were found: (a) receptors with the properties of Pacinian corpuscles (PC-receptors); (b) receptors which showed burst discharges for up to 500 ms after the onset of a constant force stimulus (RA-receptors); and (c) receptors which discharged throughout a constant force stimulus (SA-receptors). The afferent conduction velocities of these units were in the same range as those of receptors from the surrounding hairy skin. A considerable proportion of receptors from both skin areas had no collaterals in the dorsal columns. The afferent outflow after short skin indentations of up to 5 μ displacement consisted of impulses from PC-receptors only. Stimuli of 20 μ recruited between 50 and 100 afferent units of which less than 10% were other than PC-units. During constant force stimuli the afferent outflow came from SA-receptors only. Ten seconds after stimulus onset a 500 g stimulus evoked an afferent discharge of about 1000 imp/s and a 1000 g stimulus of about 1700 imp/s. At all times a power function of the form F=K · (S−S0)n related the afferent discharge F to the stimulus intensity S. The exponents were around n=0.5 and tended to increase in the course of the stimulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239165
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  • 3
    Electronic Resource
    Electronic Resource
    Two specific feedback pathways to the central afferent terminals of phasic and tonic mechanoreceptors (1968)
    Springer
    Experimental brain research 6 (1968), S. 116-129 
    Details
    ISSN: 1432-1106
    Keywords: Cutaneous afferents ; Primary afferent depolarization ; Presynaptic inhibition ; Surround inhibition ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five types of mechanoreceptor afferents of the cat's hind foot, the primary afferent depolarization (PAD) induced by mechanical skin stimulation was measured by testing the excitability of their terminations in the dorsal horn. Two types of skin stimuli were used to set up activity in distinct populations of rapidly and slowly adapting mechanoreceptors respectively. The experiments revealed that two systems exist to generate PAD in cutaneous afferents, both being of negative feedback character. One system is activated by impulses from rapidly adapting low threshold receptors and preferentially depolarizes the terminals of such afferents, and correspondingly, the other system is activated by and operates on the slowly adapting units. In both PAD systems the size of the depolarization is graded depending on the stimulus strength. Further, the “tonic” system displays a “surround” pattern of organization similar to that of the “phasic” system which has already been described (Schmidt et al. 1967b). In the discussion the operational relationships of both systems and their functional implications are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239166
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  • 4
    Electronic Resource
    Electronic Resource
    Iodinated 5- and 8-Hydroxyisoquinolines as Potential Amebicides (1966)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 9 (1966), S. 46-48 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00319a011
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  • 5
    Electronic Resource
    Electronic Resource
    Dorsal Root Potentials evoked by Natural Stimulation of Cutaneous Afferents (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 522-523 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The central organization and the functional significance of the powerful presynaptic inhibition of cutaneous afferent fibres2 cannot be examined in detail by using electrical stimulation of peripheral nerves, since neither is there a correlation between the nerve fibre threshold and the various ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/212522a0
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  • 6
    Electronic Resource
    Electronic Resource
    Röntgenbestrahlung und Hypothermie. Der Einfluss auf Körpergewicht, Hirngewicht, Kleinhirnentwicklung und Blutbild bei neugeborenen Hausmäusen (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 476-476 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary New-born mice were X-rayed under extreme hypothermia in order to estimate the radioprotective effect of hypothermia on body weight, brain weight, development of cerebellum and the hematopoietic system. A protective effect was found in the rate of survival, in body and brain weight, in the cerebellum and in the number of erythrocytes. After hypothermia, the repair of damage in the cerebellum and the erythropoietic system starts earlier. The protected mature cerebellum shows an approximately normal status. Hypothermia does not prevent the initial decrease of lymphocytes caused by X-rays, and it produces a severe disturbance of hemoglobin content.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01900763
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  • 7
    Electronic Resource
    Electronic Resource
    Das Aminosäurespektrum des Liquor cerebrospinalis bei entzündlichen Erkrankungen des Zentralnervensystems (1967)
    Springer
    European archives of psychiatry and clinical neuroscience 209 (1967), S. 395-403 
    Details
    ISSN: 1433-8491
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Mittels Säulenchromatographie nach Moore u. Stein sowie Matthias wurde der Aminosäuregehalt des Liquor cerebrospinalis bei entzündlichen Erkrankungen des Zentralnervensystems untersucht. Zur Bestimmung durchschnittlicher „Normalwerte“ verwendeten wir Liquores von Patienten mit Epilepsien, Durchblutungsstörungen, praesenilen Hirnatrophien, frühkindlichen Hirnschädigungen und Begutachtungsfällen, bei denen im übrigen normale Laborbefunde erhalten worden waren. Die Liquores Multiple Sklerose-Kranker ergaben eine geringe Verminderung des Glutamingehaltes, zeigten aber sonst keine Auffälligkeiten. Bei drei Liquoruntersuchungen von Patienten mit entzündlichen Erkrankungen (Meningitis, Panencephalitis) wurden Erhöhungen der aliphatischen Aminosäuren Glycin, Alanin, Cystin, Valin, Methionin und Ornithin/Lysin registriert. Bei einer Meningoencephalitis fand sich ein extrem hoher Glutamin- und Arginin-Wert. Unsere Untersuchungen zeigen, daß ein einheitliches Aminosäuremuster des Liquor cerebrospinalis für entzündliche Erkrankungen des Zentralnervensystems nicht existiert. Die Liquores Multiple Sklerose-Kranker in der akuten Phase zeigen die geringsten Abweichungen. Eine Erklärung der verschiedenen anderen abnormen Aminosäurebefunde kann noch nicht gegeben werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341977
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  • 8
    Electronic Resource
    Electronic Resource
    Das Liquoreiweißspektrum und seine differentialdiagnostische Bedeutung bei Entzündungen und Tumoren des ZNS (1965)
    Springer
    Journal of neurology 187 (1965), S. 122-135 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00242694
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  • 9
    Electronic Resource
    Electronic Resource
    Immunoelektrophoretischer Beitrag zur „essentiellen Paraproteinose“ und zum „soliden Plasmocytom“ mit neurologisch-psychiatrischer Symptomatik (1969)
    Springer
    Journal of neurology 195 (1969), S. 226-240 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über vier Patienten mit inhomogener neurologisch-psychiatrischer Symptomatik berichtet, die immunologisch Zeichen einer essentiellen, kryptogenetischen Paraproteinose boten. Auf die besondere Stellung dieser Stoffwechselanomalie oder -entgleisung wird hingewiesen und ihre pathophysiologische Bedeutung interpretiert. Außerdem fand ein histologisch gesichertes solides Plasmocytom (Fall 5) im Kleinhirnbrückenwinkelbereich Erwähnung.
    Notes: Summary 4 patients with non-homogeneous neurological and psychiatric symptoms, displaying evidence of essential cryptogenetic paraproteinosis are described. The distinct nature of this metabolic anomaly or derangement is pointed out and its pathophysiological implications are interpreted. In addition mention is made of a solid plasmacytoma of the cerebellopontile angle (case 5), which was verified by histology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00242470
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  • 10
    Electronic Resource
    Electronic Resource
    Beitrag zur ultrastrukturellen Darstellung der Liquorzellen (1967)
    Springer
    Journal of neurology 192 (1967), S. 209-225 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In diesem Beitrag wird nach der Schilderung der Methodik an Hand von ultrastrukturellen Darstellungen monocytärer, makrophagocytärer, eosinophiler und tumorverdächtiger Liquorzellen versucht, auf eine funktionelle Interpretation der Zellbilder hinzuweisen. Die wesentlichsten Zellorganellen finden Erwähnung.
    Notes: Summary This report gives a description of our electron microscope technique. Evaluating the ultrastructure of monocytes, macrophagocytes, eosinophils, and suspected tumor cells from cerebrospinal fluid we try to emphasize a functional interpretation. The essential cellular organelles are mentioned.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00244166
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