Electronic Resource
Springer
Psychopharmacology
1 (1959), S. 117-123
ISSN:
1432-2072
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The distribution of tritium-labeled JB 318 (N-ethyl-3-piperidyl benzilate) was studied in rats. Over 95% of the drug was excreted by way of the kidneys within 2 hours after administration. About 0.1% of the total drug was found in the central nervous system with the largest cencentration in the caudate nucleus and hypothalamus. Over 60% was bound to the mitochondria of brain with the remainder equally distributed between the supernatant and nuclear-debris fraction. The drug appears to be tightly bound to mitochondria, since it is released with great difficulty.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00409111
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