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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 69 (1947), S. 2239-2240 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 4 (1948), S. 31-31 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Following intravenous injection of pyruvic acid (PA) in the form of the sodium salt in the normal rabbit the level of PA in the blood rises, falling again to the initial level after 60 minutes. In the case of the alloxandiabetic animal the elimination of PA administered in equal doses is markedly retarded. If animals are used that suffer from a progredient alloxan diabetes leading to death in coma, an increased endogenous hyperpyruviæmia can be demonstrated. Insulin plays no part in the regulation of PA metabolism; through the application of aneurin, however, one succeeds in enabling the organism to make use of PA. A separate report will deal with the complex relations holding in endogenous hyperpyruviæmia in coma.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 208 (1949), S. 74-87 
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 4 (1948), S. 195-196 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the end-stage of progressive alloxan diabetes of the rabbit we have been able to overcome the acute pyruvic acidosis by the use of phosphorylated vitamin B1 (cocarboxylase) together with vitamin B2, while it is impossible to cure the endogen hyperpyruviæmia with simple vitamin B1. The superiority of the coferment over the vitamin, which is only effective at the beginning of the decompensation, implies the existence of a disturbance in the phosphorylation during the crisis of diabetic metabolism. We have been successful in preventing the inevitable death in coma of diabetic rabbits by doses of cocarboxylase + riboflavin, and we were able to keep them alive by continuous doses of insulin together with vitamin B1 and B2.
    Type of Medium: Electronic Resource
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