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Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein (1980)

Younes, M. ; Siegers, C. -P.

Springer

Archives of toxicology 45 (1980), S. 61-65

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ISSN: 1432-0738

Keywords: (+)-Cyanidanol-3 ; Diethyl ditbiocarbamate ; Dimethyl aminoethanol ; Dimethyl sulfoxide ; Hepatotoxicity ; Irreversible binding ; Rat liver microsomes

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Dithiocarb and (+)-cyanidanol-3 prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, deanol and DMSO, inhibited covalent binding of [3H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effective inhibitors. The concentrations of the antidotes yielding 50% inhibition (I50) valued 1 · 8 × 10−5 M for dithiocarb and 2 · 1 × 10−5 M for (+)-cyanidanol-3.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00303296

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