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  • Blood-brain barrier  (2)
  • (−)-Propranolol  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Ethanol-induced increase in brain concentrations of administered neutral amino acids (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 314 (1980), S. 47-50 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Ethanol ; Blood-brain barrier ; Carrier transport ; Tyrosine ; Tryptophan ; 5-Hydroxytryptophan ; α-Methyldopa
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ethanol 2 g kg−1 i.p. to rat increased the concentrations in the brain of administered large neutral amino acids (tyrosine, tryptophan, 5-hydroxytryptophan and α-methyldopa). We have previously found a similar effect of ethanol on administered l-Dopa, resulting in increased brain/plasma ratios of dopa. Since large neutral amino acids are known to compete with each other for the carrier-mediated transport into the brain we suggest that the increased concentrations of the administered amino acids in the brain are at least partly the consequence of the ethanol-induced decrease in plasma amino acids observed previously.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00498430
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Isoprenaline increases brain concentrations of administered l-dopa and l-tryptophan in the rat (1982)
    Springer
    Psychopharmacology 77 (1982), S. 98-100 
    Details
    ISSN: 1432-2072
    Schlagwort(e): l-dopa ; Tryptophan ; Brain concentration ; Isoprenaline ; Carrier transport ; Blood-brain barrier ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A small dose of isoprenaline or saline was administered intraperitoneally to rats 20 min before the administration of one of the amino acids l-dopa or l-tryptophan. Isoprenaline caused a marked increase in the brain concentration of the administered amino acid. Isoprenaline has previously been shown to cause a decrease in at least some of those plasma amino acids which compete with l-dopa and tryptophan for carrier-mediated transport into the brain. The effect of isoprenaline on the concentrations of dopa and tryptophan in the brain is suggested to be at least partly caused by a change in the relationship between endogeneous and administered amino acids. It is also possible that a direct effect of isoprenaline on the blood-brain barrier transport system contributes to the effect. The reported finding might be of clinical interest in view of the therapeutic importance of aromatic amino acids with a central site of action.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00436106
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  • 3
    Digitale Medien
    Digitale Medien
    Effects of hypophysectomy, adrenalectomy and (−)-propranolol on ethanol-induced decrease in plasma amino acids (1981)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 317 (1981), S. 214-218 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Ethanol ; Plasma amino acids ; Adrenalectomy ; Hypophysectomy ; (−)-Propranolol ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In previous studies we have demonstrated that an acute dose of ethanol cause an immediate decrease in most plasma amino acids in both man and rat. This effect of ethanol is partly inhibited by the β-adrenergic antagonist (−)-propranolol, partly by adrenalectomy or hypophysectomy and almost completely by a combination of adrenalectomy with (−)-propranolol. This finding suggests an involvement of both β-adrenergic mechanisms and steroids from the adrenal cortex in the ethanol-induced decrease in plasma amino acids.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00503819
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