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Digitale Medien

Cadmium-binding protein in a cadmium-resistant strain of Saccharomyces cerevisiae

Inouhe, M. ; Hiyama, M. ; Tohoyama, H. ; [weitere]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/General Subjects 993 (1989), S. 51-55

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ISSN: 0304-4165

Schlagwort(e): (S. cerevisiae 301N) ; Cadmium ion ; Cadmium resistance ; Metallothionein

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie , Medizin , Physik

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1016/0304-4165(89)90142-6

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Digitale Medien

Refractory thrombocytopenia with chromosome 11q23 abnormality (1996)

Imoto, S. ; Hayashi, Y. ; Matsui, T. ; [weitere]

Springer

Annals of hematology 73 (1996), S. 99-102

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ISSN: 1432-0584

Schlagwort(e): Key words Myelodysplastic syndromes ; Refractory thrombocytopenia ; Megakaryocytopoiesis ; Chromosome 11q23

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Although cytopenia is a common manifestation of myelodysplastic syndrome (MDS), isolated thrombocytopenia is rare. The term "refractory thrombocytopenia" (RTC) has been proposed as a counterpart of refractory anemia. We describe here a case of RTC associated with chromosome abnormality on 11q23. A 59-year-old man was admitted because of severe thrombocytopenia. A bone marrow examination revealed an increased number of micromegakaryocytes and the absence of normal-sized megakaryocytes without obvious dysplasia in either the myeloid or the erythroid lineage. A remarkable increase of GPIIb/IIIa (CD41a)-positive precursor cells in the bone marrow was observed. Cytogenetic examination detected the chromosome abnormality, an addition on chromosome 11q23. Translocation of the HRX gene was not detectable by Southern blot analysis. The diagnostic problems of isolated thrombocytopenia and possible participation of gene(s) on chromosome 11q23 in megakaryocytopoiesis as well as early hematopoiesis are discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002770050209

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Digitale Medien

Plasma cell leukemia with myelofibrosis (1994)

Murayama, T. ; Matsui, T. ; Hayashi, Y. ; [weitere]

Springer

Annals of hematology 69 (1994), S. 151-152

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ISSN: 1432-0584

Schlagwort(e): Plasma cell leukemia ; Myelofibrosis Chemotherapy ; Bone marrow biopsy

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We describe a case of plasma cell leukemia associated with myelofibrosis. A 60-year-old woman was admitted due to lumbago and monoclonal hypergammaglobulinemia. Peripheral blood showed about 40% of plasma-cell-like cells. A bone marrow aspiration was dry tap. The patient was diagnosed as having plasma cell leukemia with myelofibrosis by bone marrow biopsy. Plasma cell leukemia as well as myelofibrosis improved with combination chemotherapy using vincristine, pirarubicin, and dexamethasone. However, when plasma cell leukemia became resistant to chemotherapies, myelofibrosis also reappeared. This case strongly suggests the pathogenetic relationship between plasma cell leukemia and myelofibrosis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01695697

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