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Digitale Medien

Synthetic phospholipids as substrates for phospholipase C from Bacillus cereus

Ries, U. ; Fleer, E.A.M. ; Unger, C. ; [weitere]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1125 (1992), S. 166-170

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ISSN: 0005-2760

Schlagwort(e): Alkylphosphocholine ; Diacylglycerol ; Lysophospholipid ; Phospholipase C ; Synthetic phospholipid

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie , Medizin , Physik

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(92)90041-S

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Digitale Medien

Blut-Hirnschranke und Penetration von Zytostatika (1985)

Unger, C. ; Eibl, H. ; Heyden, H. -W. ; [weitere]

Springer

Journal of molecular medicine 63 (1985), S. 565-571

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ISSN: 1432-1440

Schlagwort(e): Blood-brain barrier ; Drug transfer ; Alkylglycerols

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The penetration of 12 commonly used anticancer agents through the blood-brain barrier (BBB) was measured in a rat model using a single-injection tissue-sampling technique. Two of the tested drugs penetrated the barrier, but only to a limited extent. Entry of the drugs into the brain tissue critically depends on molecular weight and lipophilia of the respective test compound. For drugs with a molecular weight of less than 500, BBB simply behaves like an oil/water interphase, whereas drugs with a molecular weight greater than 500 are practically excluded from transport through the BBB even if they show a favourable oil/water partition coefficient. However, permeability of cytostatics was strongly increased if short chain alkylglycerols, up to final concentrations of about 0.3 mol/l were added to the injected solution. Under these conditions the Brain-Uptake-Index (BUI) reached values up to about 50% (cyclophosphamide), depending on lipid solubility and molecular dimension of the respective test compound and the alkyl chain length of the glycerol derivative.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01733202

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Digitale Medien

Brain uptake and CNS levels of 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (HECNU) (1987)

Unger, C. ; Eibl, H. ; Engel, J. ; [weitere]

Springer

Investigational new drugs 5 (1987), S. 361-364

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ISSN: 1573-0646

Schlagwort(e): 1-(2-chloroethyl)-1-nitroso-3(2-hydroxyethyl)urea (HECNU) ; blood brain barrier ; cerebrospinal fluid concentration

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Abstract The uptake of 14C-labeled 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl) urea (HECNU) into the brain was investigated in the rat after intracarotid injection according to the method of OLDENDORF, as well as in cisternal cerebrospinal fluid obtained by suboccipital puncture after i.v. injection of the drug. The brain uptake index was 31.9 ± 2.9%. Cerebrospinal fluid/blood quotients after i.v. injection were 0.82 at 10 min and 1.10 at 60 min. The results of both methods clearly show that HECNU, in spite of its hydrophilic property, easily penetrates the blood-brain barrier.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00169975

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