ISSN:
1434-4475
Keywords:
2,2,5-Trimethyl-1,3-dioxolane-4-carbaldehydes
;
aldopentose diethyl dithioacetals
;
lead tetraacetate cleavage
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A simple and efficient procedure for the syntheses of all four stereoisomers of the 2,2,5-trimethyl-1,3-dioxolane-4-carbaldehydes1a–1d has been developed. Starting with readily available aldopentose diethyl dithioacetals2,6,10 and14, the title compounds were obtained by a selective protecting group strategy and subsequentRaney-nickel reduction, followed by lead tetraacetate cleavage. This procedure allows an application on a multigram scale.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01277638
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