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  • 1985-1989  (3)
  • 42.60B  (2)
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)  (1)
  • 1
    ISSN: 1432-0738
    Keywords: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) ; Mice ; Mutant strains ; Porphyria ; Liver functiontests ; Oxygen consumption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment of mice of the A2G-hr/+ congenic line with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in the development of hepatic porphyria over a period of 4 weeks. Female mice responded to a lesser extent than did males. The degree of porphyria in haired heterozygotes (hr/+) was less than in the corresponding hairless homozygotes (hr/hr) and the haired mice had lower resting metabolic rates than hairless mice. Adaptation of mice of either genotype to a 32–33 °C environment resulted in a decrease in resting metabolic rate and a reduction in hepatic porphyrin levels. Histologically-demonstrated necrotic changes in livers were accompanied by increased activity of alanine aminotransferase and sorbitol dehydrogenase in the plasma; however, there was no clear temporal trend in plasma enzyme levels. Elevated environmental temperature reduced the plasma alanine aminotransferase activity. The study provided evidence for a pleiotropic effect of variation at the hr locus being expressed in TCDD hepatotoxicity. Suggestions for mechanisms whereby the effect can be mediated through alterations in resting metabolic rate are made.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 37 (1985), S. 171-179 
    ISSN: 1432-0649
    Keywords: 42.55D ; 42.60B ; 58.80
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The performance of a compact uv photo-preionized TE laser is studied in the pressure range 1–5 bar. As the pressure is increased, the laser pulse shape is little altered, but both the peak power and the total output pulse energy increase significantly with pressure, even for constant input electrical energy. For various gas mixtures and excitation source capacitors the measurements suggest approximate output energy scaling with the product of the source charge per unit electrode area [C.m−2] and the molecular partial pressure [CO2+N2+CO]. This is explained in terms of the pressure-dependent discharge impedance. An input-energy-related discharge instability limits the optimum laser pressure to 1.5–2.5 bar, and we show that, at constant input energy, the instability boundary depends on the molecular partial pressure alone. The pre-ionization photo-electron yield varies negligibly with pressure, but the discharge tolerance to added oxygen decreases asp −3 top −4, dependent on gas mixture. Nevertheless sealed operation for 〉105 shots has been obtained with a 5% CO2∶5% CO∶3% N2∶2% H2∶85% He gas mixture at a total pressure of 5 bar.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 37 (1985), S. 219-221 
    ISSN: 1432-0649
    Keywords: 42.55D ; 33.80E ; 52.80 ; 42.60B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A short pulse (100 ns) high-energy x-ray source has been used to preionize a transversely excited carbon dioxide gas discharge laser of 600 cm3 active volume. The maximum output power of 60 MW in a 50 ns FWHM pulse was achieved from a CO2−N2−He−CO−Xe static gas mixture at 600 Torr pressure. The energy conversion efficiency was 6%.
    Type of Medium: Electronic Resource
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