ISSN:
1432-2013
Keywords:
Chloride channel
;
Rat
;
Skeletal muscle
;
Stereoisomers
;
2-(p-chloro-phenoxy) isobutyric acid
;
Clofibric acid
;
Myotonia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The S-(−) isomers of a series of clofibric acid analogs produced only a block of chloride conductance of rat skeletal muscle fibers with increasing concentrations until block was nearly complete. The R-(+) isomers, on the other hand, at low concentrations increased chloride conductance by as much as 9% to 39% and at higher concentrations decreased chloride conductance, but never by more than 27% of the control value. The actions of the enantiomeric pairs to either produce or inhibit myotonic excitability paralleled their ability to block or increase chloride conductance, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581238
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