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  • 1
    Electronic Resource
    Electronic Resource
    Carbon-13 nuclear magnetic resonance probe of active-site ionizations in human carbonic anhydrase B (1977)
    s.l. : American Chemical Society
    Biochemistry 16 (1977), S. 2241-2247 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00629a031
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  • 2
    Electronic Resource
    Electronic Resource
    MYOTONIA IN THE GOAT (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 317 (1979), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1979.tb56540.x
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  • 3
    Electronic Resource
    Electronic Resource
    Molecular-replacement structure of guinea pig IgGl pFc' refined at 3.1Å resolution (1985)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 41 (1985), S. 362-368 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108768185002270
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  • 4
    Electronic Resource
    Electronic Resource
    Photodynamic effect of dye on frog muscle fibre using microelectrodes (1964)
    Springer
    Cellular and molecular life sciences 20 (1964), S. 368-369 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Kurarisierte und nichtkurarisierte Frosch-Sartorii zeigten einen veränderlichen Grad der Depolarisation, wenn sie mit Bengalrot (1:25 000) gefärbt und durch scharf zentriertes Licht einer 300-Watt-Tungsten-Lampe beleuchtet wurden. Die Depolarisation wurde niemals im äusseren Natrium und ohne Sauerstoff beobachtet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02147962
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  • 5
    Electronic Resource
    Electronic Resource
    Pentobarbital: Presynaptic effect in the squid giant synapse (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 487-488 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In concentrations that produced synaptic blockade in the squid giant synapse, sodium pentobarbital produced a dose-related, reversible decrease of the ‘calcium spike’ of the presynaptic terminal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922226
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  • 6
    Electronic Resource
    Electronic Resource
    Tumbling in pigeons (1974)
    [s.l.] : Nature Publishing Group
    Nature 252 (1974), S. 706-708 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Each filming session involved releasing a hand-held pigeon 0.3 m above a flat surface and activating the camera and high intensity lamps for a period of 1?2 s. Although we were mainly interested in the initial tumbling motions, 5?10 somersaults by each pigeon were filmed during this short time. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/252706a0
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  • 7
    Electronic Resource
    Electronic Resource
    Optical evidence for a chloride conductance in the T-system of frog skeletal muscle (1990)
    Springer
    Pflügers Archiv 416 (1990), S. 288-295 
    Details
    ISSN: 1432-2013
    Keywords: Chloride conductance ; Skeletal muscle ; T-system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract T-system action potentials were recorded optically from intact frog skeletal muscle fibers stained with the non-penetrating potentiometric dye NK-2367. The effect of chloride removal on the falling phase of the radially propagating tubular action potential was studied to determine whether a chloride conductance located in the T-system membranes contributes to tubular repolarization during activity. Our results show that, in chloride-free Ringer, repolarization of the tubular action potential is significantly slowed. Moreover, the late phase of tubular repolarization is characterized by a large afterpotential, which is highly temperature-dependent and appears as a secondary peak above 10° C. The optical data were compared with predicted T-system action potentials generated from a radial cable equivalent circuit model of the T-system, in which the effects of a distributed tubular leak conductance were tested. Results of this analysis are consistent with the proposal that some of the outward repolarization current during the T-system action potential is drawn across a chloride conductance located in the T-system membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00392065
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  • 8
    Electronic Resource
    Electronic Resource
    Suppression of charge movement by calcium antagonists is not related to calcium channel block (1987)
    Springer
    Pflügers Archiv 409 (1987), S. 217-219 
    Details
    ISSN: 1432-2013
    Keywords: Calcium antagonist drugs ; calcium currents ; charge movement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The calcium channel-inhibiting drugs nitrendipine and diltiazem represent two important classes of organic calcium antagonists. In the present study, the effect of these drugs on calcium currents and charge displacement currents in bullfrog semitendinosus muscle fibers was examined using a vaseline gap voltage clamp. Nitrendipine (10 μM) reduced the quantity of charge that moved both during the ON phase (QON) and the OFF phase (QOFF) of charge movement. This action appeared to be most selective for QON. However, at this same concentration, nitrendipine had no blocking action on inward calcium currents. In contrast to these findings, diltiazem blocked calcium currents in a concentration-dependent manner, while slightly increasing the quantity of charge moved during QON and QOFF. The enhancement of charge movement by diltiazem resulted from two actions. First, diltiazem shifted the voltage-dependence of charge movement to more negative potentials. Second, diltiazem increased the maximum amount of charge moved. (Supported by NIH NS 03178 and HL 07382.)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584775
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  • 9
    Electronic Resource
    Electronic Resource
    Modulation of rat skeletal muscle chloride channels by activators and inhibitors of protein kinase C (1991)
    Springer
    Pflügers Archiv 418 (1991), S. 500-503 
    Details
    ISSN: 1432-2013
    Keywords: Rat skeletal muscle ; Phorbol esters ; Staurosporine ; Protein kinase C ; Chloride channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The membrane electrical parameters and component conductances of rat extensor digitorum longus muscle fibres were studied in vitro at 30 °C with standard two microelectrode square pulse cable analysis in the presence of protein kinase C (PKC) activators and inhibitors. The PKC activator, 4-β-phorbol-12,13 dibutyrate (4-β-PDB), (2–90nM) blocked up to 67% chloride conductance (G Cl) in rat skeletal muscle fibres and induced myotonic hyperexcitability. The concentration necessary to produce a 50% block of the membrane G Cl was 23 nM. The “inactive” 4-α-phorbol-12,13 dibutyrate had no effect at 2 μM. The blocking effect of 4-β-PDB on G Cl was prevented by preincubation of the preparations with the PKC inhibitors, staurosporine (1–5 μM) and tetrahydropapaverolone (50–100 μM). The blocking effects on membrane G Cl of 4-β-PDB and its antagonism by the inhibitors used support the concept of the involvement of PKC in regulating Cl channels of mammalian skeletal muscle fibres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00497778
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  • 10
    Electronic Resource
    Electronic Resource
    Enantiomers of clofibric acid analogs have opposite actions on rat skeletal muscle chloride channels (1988)
    Springer
    Pflügers Archiv 413 (1988), S. 105-107 
    Details
    ISSN: 1432-2013
    Keywords: Chloride channel ; Rat ; Skeletal muscle ; Stereoisomers ; 2-(p-chloro-phenoxy) isobutyric acid ; Clofibric acid ; Myotonia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The S-(−) isomers of a series of clofibric acid analogs produced only a block of chloride conductance of rat skeletal muscle fibers with increasing concentrations until block was nearly complete. The R-(+) isomers, on the other hand, at low concentrations increased chloride conductance by as much as 9% to 39% and at higher concentrations decreased chloride conductance, but never by more than 27% of the control value. The actions of the enantiomeric pairs to either produce or inhibit myotonic excitability paralleled their ability to block or increase chloride conductance, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581238
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