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  • 1
    Digitale Medien
    Digitale Medien
    “Varicoid change” of bile canaliculi in rat liver at an early phase of ischaemia-reperfusion injury (1994)
    Springer
    Virchows Archiv 425 (1994), S. 505-512 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Ischaemia-reperfusion injury ; Actin filament ; Bile canaliculus ; Confocal laser scanning microscopy ; 3-D microstructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To elucidate early changes and the mechanism of ischaemia-reperfusion liver injury, we investigated three-dimensional microstructural changes of cellular actin filaments in rat livers using confocal laser scanning microscopy. The liver tissues of a reperfusion group were examined 12 h after removal of a vascular clamp. Fixed tissues were stained with fluorescein-labelled phalloidin to obtain stereoscopic images of the actin filaments and these were compared with histological findings. The images of bile canaliculi showed that multiple abnormal minute diverticular arose from the canalicular membranes and fused with one another, resulting in irregular dilation of the bile canaliculi. These changes were observed after 15 min of ischaemia and reperfusion in which no significant necrosis was seen. The frequency and degree of these changes were strictly dependent on the periods of ischaemia (15–60 min). We called these bile canaciluar lesions “varicoid changes”. The liver of an ischaemia group taken after persistent clamping without reperfusion did not show these changes. Our findings suggest that the varicoid change in the bile canaliculi is probably due to alterations in the actin polymerization-depolymerization cycle and is a pathognomonic change of ischaemia-reperfusion liver injury.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00197554
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    A quantitative analysis of human astrocytosis (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 535-537 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Astrocytosis ; Hyperplasia ; Quantitative analysis ; Immunohistochemistry ; Human
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The number of astrocytes in an atrophic human brain was counted with the aid of immunohistochemistry for glial fibrillary acidic protein. Microscopically, astrocytosis was remarkable in the cerebral neocortex and white matter. Taking the cortical atrophy into consideration, however, the total number of astrocytes in the cortical layers II – VI was not increased. The number of astrocytes in the white matter was not increased either. It is indicated that astrocytosis does not always mean hyperplasia (net increase of total number) of astrocytes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687144
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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