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  • 1
    ISSN: 1432-2013
    Keywords: dv/dt of Ventricular Pressure Curve of the Heart ; dp/dt of Ventricular Pressure Curve ; Performance of the Heart ; Metabolic Alcalosis ; Pressure Load ; Increased Preload ; dv/dt der Ventrikeldruckkurve des Herzens ; dp/dt der Ventrikeldruckkurve ; Herzarbeit ; Herzleistung ; metabolische Alkalose ; Druckarbeit ; Füllungsdruckerhöhung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden Untersuchungen am isolierten Katzenherzen mit der Fragestellung durchgeführt, obdp/dt max unddv/dt max der Druckkurve des linken Ventrikels mit Parameters korrelieren, die sich nicht primär aus der Druckkurve ergeben. Besonders interessierten dabei mögliche Beziehungen zu Arbeit und Leistung des linken Ventrikels. Durch metabolische Alkalose (pH 7,8) erhöhte Druckbelastung und Füllungsdruckerhöhung wurden Dynamik und somit physikalisches Resultat der Systole verändert. Ohne Berücksichtigung dieser unterschiedlichen Versuchsbedingungen ergab sich für jeden Versuch eine gesicherte Korrelation zwischendv/dt max und Arbeit bzw. Leistung des linken Ventrikels. Dagegen ließen sich solche Korrelationen zum Schlag-bzw. Herzzeitvolumen und zur Beschleunigungsarbeit nicht nachweisen. Werden die entsprechenden Korrelationen für die genannten Versuchsbedingungen getrennt untersucht, so besteht teilweise eine Beziehung zwischendv/dt max und Schlag-, Herzzeitvolumen bzw. Beschleunigungsarbeit. dp/dt max hängt in ähnlicher Weise von Arbeit und Leistung des linken Ventrikels ab, es ergaben sich jedoch teilweise kleinere Korrelationskoeffizienten. Aus den Ergebnissen läßt sich eine Proportionalität zwischendv/dt max als wesentlichem dynamischen Parameter der Druckarbeit des Ventrikels und dem physikalischen Resultat seiner Systole ableiten.
    Notes: Summary Experiments were performed at isolated cat hearts to examine correlations betweendp/dt max ordv/dt max of the ventricular pressure curve and stroke volume, cardiac index, 1/2 mv2 and performance of the left ventricle. By metabolic alcalosis, pressure load and increased preload the dynamics of ventricular contraction and its physical result were varied. Each heart showed an exact correlation betweendv/dt max and the physical work of the left chamber per systole, respectively performance. Controversely, there could not be found correlations betweendv/dt max and stroke volume, cardiac index and 1/2 mv2. By separate examination of these correlations at metabolic alcalosis, pressure load or increased preload, there exists a particular dependence ofdv/dt max from these parameters. However, the dependence ofdv/dt max from left ventricular work per systole is unchanged. Similar correlations were found betweendp/dt max and the left ventricular work per systole. It is concluded that there exists a proportionality betweendv/dt max as the most important derivation of the ventricular pressure curve and the physical result of ventricular contraction.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 9 (1976), S. 345-354 
    ISSN: 1432-1041
    Keywords: 3H-digitoxin ; metabolism ; spironolactone ; enzyme induction ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of spironolactone on the metabolism of intravenously administered3H-digitoxin (80 µCi) was investigated in eight patients. In three of them the labelled glycoside was given on a second occasion after spironolactone treatment had been discontinued for at least 65 days. Of total urinary radioactivity 79 % was unaltered drug and 12 % consisted of water soluble compounds. No digitoxigenin or digoxigenin and only trace amounts (〈2 %) of digoxin and the bis- and monoglycosides of digoxigenin were found. After spironolactone total urinary radioactivity was unchanged but the fraction eliminated as unchanged digitoxin fell from 79 to 66 % and the water soluble compounds increased from 12 to 26 % (p〈0.05). In addition spironolactone caused a 20 % reduction in the half-life of serum radioactivity (p〈0.01) and a 16 % reduction in the volume of distribution (p〈0.05). Induction of hepatic enzymes by spironolactone is proposed to explain the alteration in the metabolism of digitoxin in man. Both the altered metabolic pattern and the reduction in the volume of distribution appear to contribute to the reduction in half-life.
    Type of Medium: Electronic Resource
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