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Digitale Medien

Inhibitory serotonergic effects on rostral ventrolateral medullary neurons (1992)

Wang, W. H. ; Lovick, T. A.

Springer

Pflügers Archiv 422 (1992), S. 93-97

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ISSN: 1432-2013

Schlagwort(e): 5-Hydroxytryptamine ; 5-HT1A receptor ; Rostral ventrolateral medulla ; Rat ; Sympathoexcitatory drive

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract In rats anaesthetised with urethane, iontophoretic application of 5-hydroxytryptamine (5-HT) and the 5-HT1A agonists buspirone, flesinoxan and 8-hydroxy-2-(di-n-propylamino)-tetralin inhibited ongoing or amino-acid-evoked activity of neurons in the rostral ventrolateral medulla (RVLM) including barosensitive cells with spinally projecting axons. More than 90% of cells tested were inhibited by these agonists. In 5/9 cells the inhibition was reduced after intravenous spiperone (0.6 mg/kg). These results suggest that the sympathoinhibitory effects produced by microinjection of 5-HT1A agonists into the RVLM are due to a direct inhibitory action on neurons that send excitatory projections to the spinal sympathetic outflow.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00370407

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